Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer

Abstract Metastatic breast cancers are hard to treat and almost always fatal. Chloroquine diphosphate, a derivative of quinine, has long been used as a potent and commonly used medicine against different human diseases. We therefore investigated the effects of chloroquine diphosphate on a highly met...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2010-11, Vol.64 (9), p.609-614
Hauptverfasser:	Jiang, Pei-Du, Zhao, Ying-Lan, Deng, Xiao-Qiang, Mao, Yong-Qiu, Shi, Wei, Tang, Qing-Qing, Li, Zheng-Guang, Zheng, Yu-Zhu, Yang, Sheng-Yong, Wei, Yu-Quan
Format:	Artikel
Sprache:	eng
Schlagworte:	4T1 mammary tumor Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis - drug effects Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Caspase 3 - metabolism Caspase 9 - metabolism Cell Cycle - drug effects Cell Line, Tumor Cell Proliferation - drug effects Chloroquine - analogs & derivatives Chloroquine - pharmacology Chloroquine - therapeutic use Chloroquine diphosphate Cytochromes c - metabolism Female Growth inhibition Gynecology. Andrology. Obstetrics Internal Medicine Mammary gland diseases Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology Medical Education Medical sciences Membrane Potential, Mitochondrial - drug effects Metastasis Mice Mice, Inbred BALB C Mitochondrial apoptotic pathway Neoplasm Metastasis - drug therapy Pharmacology. Drug treatments Poly Adenosine Diphosphate Ribose - metabolism Tumors Xenograft Model Antitumor Assays - methods
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