Concomitant type I IFN receptor-triggering of T cells and of DC is required to promote maximal modified vaccinia virus Ankara-induced T-cell expansion

Virus-induced expansion of CD8⁺ T cells may be promoted by type I IFN receptor (IFNAR)-triggering of T cells, depending on the pathogen tested. We studied modified vaccinia virus Ankara (MVA), a promising vaccine vector candidate, which was derived from conventional vaccinia virus (VACV) by more tha...

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Veröffentlicht in:	European journal of immunology 2010-10, Vol.40 (10), p.2769-2777
Hauptverfasser:	Frenz, Theresa, Waibler, Zoe, Hofmann, Janin, Hamdorf, Matthias, Lantermann, Markus, Reizis, Boris, Tovey, Michaël G, Aichele, Peter, Sutter, Gerd, Kalinke, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Arenaviridae CD11c Antigen - immunology CD8+ T‐cell expansion CD8-Positive T-Lymphocytes - immunology Dendritic Cells - immunology Epitopes, T-Lymphocyte Expansion Flow Cytometry Genetic Vectors - immunology Interferon Type I - immunology Lymphocyte Activation - immunology Lymphocytes Lymphocytic choriomeningitis virus Mice Modified vaccinia virus Ankara Signal Transduction - immunology T cell receptors Type I IFN Vaccinia virus Vaccinia virus - immunology Viruses
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