γ-Secretase Inhibitors Induce Erythroid Differentiation in Erythroid Leukemia Cell Lines

Notch signaling regulates the fate of hematopoietic stem cells and leukemia cells. However, the role of Notch in erythroid differentiation remains unclear. We examined the effects of three γ-secretase inhibitors (GSI-IX, GSI-XII and GSI-XXI) that inhibit Notch signaling on the in vitro growth and di...

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Veröffentlicht in:	Anticancer research 2010-10, Vol.30 (10), p.4071-4074
Hauptverfasser:	OKUHASHI, Yuki, ITOH, Mai, ARAI, Ayako, NARA, Nobuo, TOHDA, Shuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amyloid Precursor Protein Secretases - antagonists & inhibitors Basic Helix-Loop-Helix Transcription Factors - biosynthesis Basic Helix-Loop-Helix Transcription Factors - genetics Biological and medical sciences Cell Differentiation - drug effects Cell Growth Processes - drug effects Cell Line, Tumor Dipeptides - pharmacology Erythroid Cells - drug effects Erythroid Cells - enzymology Erythroid Cells - pathology Gene Expression - drug effects Hematologic and hematopoietic diseases Homeodomain Proteins - biosynthesis Homeodomain Proteins - genetics Humans Leukemia, Erythroblastic, Acute - drug therapy Leukemia, Erythroblastic, Acute - enzymology Leukemia, Erythroblastic, Acute - genetics Leukemia, Erythroblastic, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - pathology Protease Inhibitors - pharmacology Transcription Factor HES-1 Tumors
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