Cross-clade protection against HPAI H5N1 influenza virus challenge in BALB/c mice intranasally administered adjuvant-combined influenza vaccine

The avian H5N1 influenza virus has the potential to cause a new pandemic. The increasing number of recent outbreaks of highly pathogenic avian influenza H5N1 in birds and humans emphasizes the urgent need to develop a potent H5N1 vaccine. Here, we studied the immunogenicity and protective effect of...

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Veröffentlicht in:	Veterinary microbiology 2010-11, Vol.146 (1-2), p.17-23
Hauptverfasser:	Yang, Penghui, Tang, Chong, Luo, Deyan, Zhan, Zhongpeng, Xing, Li, Duan, Yueqiang, Jia, Weihong, Peng, Daxin, Liu, Xiufan, Wang, Xiliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants, Immunologic - pharmacology Administration, Intranasal animal models Animals Biological and medical sciences cross immunity cross-clade protection disease outbreaks drug formulations Enzyme-Linked Immunosorbent Assay Female Fundamental and applied biological sciences. Psychology H5N1 influenza vaccine Hemagglutination Inhibition Tests highly pathogenic avian influenza H5N1 immune response immunity immunoglobulin A Immunoglobulin A - blood immunoglobulin G Immunoglobulin G - blood inactivated vaccines Influenza A virus Influenza A Virus, H5N1 Subtype - immunology Influenza Vaccines - immunology Influenza Vaccines - pharmacology Influenza virus intranasal administration Mice Mice, Inbred BALB C Microbiology Miscellaneous Mucosal immunity Neutralization Tests Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - virology protective effect vaccination vaccine adjuvants Vaccines, Synthetic - immunology Vaccines, Synthetic - pharmacology viral diseases of animals and humans Viral Load Virology
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