18β-Glycyrrhetinic acid potentiates apoptotic effect of trichostatin A on human epithelial ovarian carcinoma cell lines
The licorice-derived compounds glycyrrhizin and 18β-glycyrrhetinic acid have been shown to induce apoptosis in various cancer cells. However, the effect of these licorice compounds on the apoptotic effect of histone deacetylase inhibitors in epithelial ovarian carcinoma cells has not been determined...
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| Veröffentlicht in: | European journal of pharmacology 2010-12, Vol.649 (1), p.354-361 |
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| creator | Lee, Chung Soo Yang, Jae Chon Kim, Yun Jeong Jang, Eun-Ra Kim, Wonyong Myung, Soon Chul |
| description | The licorice-derived compounds glycyrrhizin and 18β-glycyrrhetinic acid have been shown to induce apoptosis in various cancer cells. However, the effect of these licorice compounds on the apoptotic effect of histone deacetylase inhibitors in epithelial ovarian carcinoma cells has not been determined. We assessed the effect of 18β-glycyrrhetinic acid on trichostatin A-induced apoptosis in the human epithelial carcinoma cell lines OVCAR-3 and SK-OV-3. Trichostatin A induced nuclear damage, decreased Bid and Bcl-2 protein levels, increased in Bax levels, induced cytochrome
c release, activated caspase-8, -9 and -3, and increased tumor suppressor p53 levels. 18β-Glycyrrhetinic acid potentiated the trichostatin A-induced apoptosis-related protein activation and cell death. Unlike 18β-glycyrrhetinic acid, up to 25
μM of the pro-compound glycyrrhizin did not induce cell death and did not affect trichostatin A-induced apoptosis. The results suggest that 18β-glycyrrhetinic acid may potentiate the apoptotic effects of trichostatin A against ovarian carcinoma cell lines by increasing the activation of the caspase-8-dependent pathway as well as the activation of the mitochondria-mediated cell death pathway, leading to activation of caspases. 18β-Glycyrrhetinic acid may enhance the therapeutic effect of trichostatin A against epithelial ovarian adenocarcinoma. |
| doi_str_mv | 10.1016/j.ejphar.2010.09.047 |
| format | Article |
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c release, activated caspase-8, -9 and -3, and increased tumor suppressor p53 levels. 18β-Glycyrrhetinic acid potentiated the trichostatin A-induced apoptosis-related protein activation and cell death. Unlike 18β-glycyrrhetinic acid, up to 25
μM of the pro-compound glycyrrhizin did not induce cell death and did not affect trichostatin A-induced apoptosis. The results suggest that 18β-glycyrrhetinic acid may potentiate the apoptotic effects of trichostatin A against ovarian carcinoma cell lines by increasing the activation of the caspase-8-dependent pathway as well as the activation of the mitochondria-mediated cell death pathway, leading to activation of caspases. 18β-Glycyrrhetinic acid may enhance the therapeutic effect of trichostatin A against epithelial ovarian adenocarcinoma.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/j.ejphar.2010.09.047</identifier><identifier>PMID: 20868669</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adenocarcinoma - drug therapy ; Adenocarcinoma - metabolism ; Adenocarcinoma - pathology ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents, Phytogenic - pharmacology ; Apoptosis - drug effects ; Apoptosis Regulatory Proteins - metabolism ; Apoptosis-related protein ; Biological and medical sciences ; Cell Line, Tumor ; Cell Nucleus - drug effects ; Cell Nucleus - pathology ; Cell Survival - drug effects ; DNA Fragmentation - drug effects ; Drug Synergism ; Enzyme Activation - drug effects ; Epithelial ovarian adenocarcinoma cell line ; Female ; Female genital diseases ; Glycyrrhetinic Acid - analogs & derivatives ; Glycyrrhetinic Acid - pharmacology ; Glycyrrhizic Acid - pharmacology ; Gynecology. Andrology. Obstetrics ; Histone Deacetylase Inhibitors - pharmacology ; Humans ; Hydroxamic Acids - pharmacology ; Medical sciences ; Mitochondria - drug effects ; Mitochondria - enzymology ; Ovarian Neoplasms - drug therapy ; Ovarian Neoplasms - metabolism ; Ovarian Neoplasms - pathology ; Pharmacology. Drug treatments ; Prodrugs - pharmacology ; Synergistic effect ; Trichostatin A ; Tumor Suppressor Protein p53 - metabolism ; Tumors</subject><ispartof>European journal of pharmacology, 2010-12, Vol.649 (1), p.354-361</ispartof><rights>2010 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-67c605c63b48bfcad3b9889b15923683487f48cd40820f1667507221c67dd3393</citedby><cites>FETCH-LOGICAL-c372t-67c605c63b48bfcad3b9889b15923683487f48cd40820f1667507221c67dd3393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejphar.2010.09.047$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23403679$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20868669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Chung Soo</creatorcontrib><creatorcontrib>Yang, Jae Chon</creatorcontrib><creatorcontrib>Kim, Yun Jeong</creatorcontrib><creatorcontrib>Jang, Eun-Ra</creatorcontrib><creatorcontrib>Kim, Wonyong</creatorcontrib><creatorcontrib>Myung, Soon Chul</creatorcontrib><title>18β-Glycyrrhetinic acid potentiates apoptotic effect of trichostatin A on human epithelial ovarian carcinoma cell lines</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The licorice-derived compounds glycyrrhizin and 18β-glycyrrhetinic acid have been shown to induce apoptosis in various cancer cells. However, the effect of these licorice compounds on the apoptotic effect of histone deacetylase inhibitors in epithelial ovarian carcinoma cells has not been determined. We assessed the effect of 18β-glycyrrhetinic acid on trichostatin A-induced apoptosis in the human epithelial carcinoma cell lines OVCAR-3 and SK-OV-3. Trichostatin A induced nuclear damage, decreased Bid and Bcl-2 protein levels, increased in Bax levels, induced cytochrome
c release, activated caspase-8, -9 and -3, and increased tumor suppressor p53 levels. 18β-Glycyrrhetinic acid potentiated the trichostatin A-induced apoptosis-related protein activation and cell death. Unlike 18β-glycyrrhetinic acid, up to 25
μM of the pro-compound glycyrrhizin did not induce cell death and did not affect trichostatin A-induced apoptosis. The results suggest that 18β-glycyrrhetinic acid may potentiate the apoptotic effects of trichostatin A against ovarian carcinoma cell lines by increasing the activation of the caspase-8-dependent pathway as well as the activation of the mitochondria-mediated cell death pathway, leading to activation of caspases. 18β-Glycyrrhetinic acid may enhance the therapeutic effect of trichostatin A against epithelial ovarian adenocarcinoma.</description><subject>Adenocarcinoma - drug therapy</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - pathology</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis Regulatory Proteins - metabolism</subject><subject>Apoptosis-related protein</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Cell Nucleus - drug effects</subject><subject>Cell Nucleus - pathology</subject><subject>Cell Survival - drug effects</subject><subject>DNA Fragmentation - drug effects</subject><subject>Drug Synergism</subject><subject>Enzyme Activation - drug effects</subject><subject>Epithelial ovarian adenocarcinoma cell line</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Glycyrrhetinic Acid - analogs & derivatives</subject><subject>Glycyrrhetinic Acid - pharmacology</subject><subject>Glycyrrhizic Acid - pharmacology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Histone Deacetylase Inhibitors - pharmacology</subject><subject>Humans</subject><subject>Hydroxamic Acids - pharmacology</subject><subject>Medical sciences</subject><subject>Mitochondria - drug effects</subject><subject>Mitochondria - enzymology</subject><subject>Ovarian Neoplasms - drug therapy</subject><subject>Ovarian Neoplasms - metabolism</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Pharmacology. Drug treatments</subject><subject>Prodrugs - pharmacology</subject><subject>Synergistic effect</subject><subject>Trichostatin A</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><subject>Tumors</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM-KFDEQh4Mo7rj6BiK5iKceK0lP_lyEZdFVWPCi55CuTtMZujttklmc19oH8ZnMMKPevKSg8v2Sqo-Q1wy2DJh8v9_6_Tq6tOVQW2C20KonZMO0Mg0oxp-SDQBrG26MuSIvct4DwM7w3XNyxUFLLaXZkJ9M_3ps7qYjHlMafQlLQOow9HSNxS8luOIzdWtcSyz1yg-Dx0LjQEsKOMZcXM3QGxoXOh5mt1C_hjL6KbiJxgeXQm2hSxiWODuKfproFBafX5Jng5uyf3Wp1-T7p4_fbj8391_vvtze3DcoFC-NVChhh1J0re4GdL3ojNamY3UTIbVotRpajX0LmsPApFQ7UJwzlKrvhTDimrw7v7um-OPgc7FzyKcx3OLjIVslOXBWz0q2ZxJTzDn5wa4pzC4dLQN7Um739qzcnpRbMLYqr7E3lw8O3ez7v6E_jivw9gK4jG4aklsw5H-caEFIdeI-nDlfdTwEn2zG4Bf0fUjVue1j-P8kvwGNwqKK</recordid><startdate>20101215</startdate><enddate>20101215</enddate><creator>Lee, Chung Soo</creator><creator>Yang, Jae Chon</creator><creator>Kim, Yun Jeong</creator><creator>Jang, Eun-Ra</creator><creator>Kim, Wonyong</creator><creator>Myung, Soon Chul</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101215</creationdate><title>18β-Glycyrrhetinic acid potentiates apoptotic effect of trichostatin A on human epithelial ovarian carcinoma cell lines</title><author>Lee, Chung Soo ; Yang, Jae Chon ; Kim, Yun Jeong ; Jang, Eun-Ra ; Kim, Wonyong ; Myung, Soon Chul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-67c605c63b48bfcad3b9889b15923683487f48cd40820f1667507221c67dd3393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adenocarcinoma - drug therapy</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - pathology</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis Regulatory Proteins - metabolism</topic><topic>Apoptosis-related protein</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Cell Nucleus - drug effects</topic><topic>Cell Nucleus - pathology</topic><topic>Cell Survival - drug effects</topic><topic>DNA Fragmentation - drug effects</topic><topic>Drug Synergism</topic><topic>Enzyme Activation - drug effects</topic><topic>Epithelial ovarian adenocarcinoma cell line</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Glycyrrhetinic Acid - analogs & derivatives</topic><topic>Glycyrrhetinic Acid - pharmacology</topic><topic>Glycyrrhizic Acid - pharmacology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Histone Deacetylase Inhibitors - pharmacology</topic><topic>Humans</topic><topic>Hydroxamic Acids - pharmacology</topic><topic>Medical sciences</topic><topic>Mitochondria - drug effects</topic><topic>Mitochondria - enzymology</topic><topic>Ovarian Neoplasms - drug therapy</topic><topic>Ovarian Neoplasms - metabolism</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Pharmacology. Drug treatments</topic><topic>Prodrugs - pharmacology</topic><topic>Synergistic effect</topic><topic>Trichostatin A</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Chung Soo</creatorcontrib><creatorcontrib>Yang, Jae Chon</creatorcontrib><creatorcontrib>Kim, Yun Jeong</creatorcontrib><creatorcontrib>Jang, Eun-Ra</creatorcontrib><creatorcontrib>Kim, Wonyong</creatorcontrib><creatorcontrib>Myung, Soon Chul</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Chung Soo</au><au>Yang, Jae Chon</au><au>Kim, Yun Jeong</au><au>Jang, Eun-Ra</au><au>Kim, Wonyong</au><au>Myung, Soon Chul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>18β-Glycyrrhetinic acid potentiates apoptotic effect of trichostatin A on human epithelial ovarian carcinoma cell lines</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2010-12-15</date><risdate>2010</risdate><volume>649</volume><issue>1</issue><spage>354</spage><epage>361</epage><pages>354-361</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The licorice-derived compounds glycyrrhizin and 18β-glycyrrhetinic acid have been shown to induce apoptosis in various cancer cells. However, the effect of these licorice compounds on the apoptotic effect of histone deacetylase inhibitors in epithelial ovarian carcinoma cells has not been determined. We assessed the effect of 18β-glycyrrhetinic acid on trichostatin A-induced apoptosis in the human epithelial carcinoma cell lines OVCAR-3 and SK-OV-3. Trichostatin A induced nuclear damage, decreased Bid and Bcl-2 protein levels, increased in Bax levels, induced cytochrome
c release, activated caspase-8, -9 and -3, and increased tumor suppressor p53 levels. 18β-Glycyrrhetinic acid potentiated the trichostatin A-induced apoptosis-related protein activation and cell death. Unlike 18β-glycyrrhetinic acid, up to 25
μM of the pro-compound glycyrrhizin did not induce cell death and did not affect trichostatin A-induced apoptosis. The results suggest that 18β-glycyrrhetinic acid may potentiate the apoptotic effects of trichostatin A against ovarian carcinoma cell lines by increasing the activation of the caspase-8-dependent pathway as well as the activation of the mitochondria-mediated cell death pathway, leading to activation of caspases. 18β-Glycyrrhetinic acid may enhance the therapeutic effect of trichostatin A against epithelial ovarian adenocarcinoma.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>20868669</pmid><doi>10.1016/j.ejphar.2010.09.047</doi><tpages>8</tpages></addata></record> |
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| subjects | Adenocarcinoma - drug therapy Adenocarcinoma - metabolism Adenocarcinoma - pathology Antineoplastic Agents - pharmacology Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Apoptosis-related protein Biological and medical sciences Cell Line, Tumor Cell Nucleus - drug effects Cell Nucleus - pathology Cell Survival - drug effects DNA Fragmentation - drug effects Drug Synergism Enzyme Activation - drug effects Epithelial ovarian adenocarcinoma cell line Female Female genital diseases Glycyrrhetinic Acid - analogs & derivatives Glycyrrhetinic Acid - pharmacology Glycyrrhizic Acid - pharmacology Gynecology. Andrology. Obstetrics Histone Deacetylase Inhibitors - pharmacology Humans Hydroxamic Acids - pharmacology Medical sciences Mitochondria - drug effects Mitochondria - enzymology Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Pharmacology. Drug treatments Prodrugs - pharmacology Synergistic effect Trichostatin A Tumor Suppressor Protein p53 - metabolism Tumors |
| title | 18β-Glycyrrhetinic acid potentiates apoptotic effect of trichostatin A on human epithelial ovarian carcinoma cell lines |
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