Gas-liquid chromatographic analysis of fluoropyrimidine nucleosides and fluorouracil in plasma and urine

A gas-liquid chromatographic method employing on-column alkylation and a nitrogen-sensitive detector was developed for the analysis of 5-fluoro-2′-deoxyuridine, 5-fluorouridine, and 5-fluorouracil in plasma and urine. Samples (0.72 ml) containing the fluoropyrimidine and internal standard (5-chloro-...

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Veröffentlicht in:	Analytical biochemistry 1985-01, Vol.147 (2), p.478-486
Hauptverfasser:	Williams, Walter M., Warren, Barbour S., Lin, Fu-hsiung
Format:	Artikel
Sprache:	eng
Schlagworte:	5-fluoro-2′-deoxyuridine 5-fluorouracil 5-fluorouridine Analysis Animals Biological and medical sciences Chromatography, Gas Chromatography, Ion Exchange Dogs Floxuridine - analysis Floxuridine - metabolism Fluorouracil - analysis gas-liquid chromatography General pharmacology Humans Hydrogen-Ion Concentration ion-exchange chromatography Kidney - metabolism Kinetics Medical sciences pharmacokinetics Pharmacology. Drug treatments Uridine - analogs & derivatives Uridine - analysis
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