PREDISPOSITION FOR CHOLERA OF INDIVIDUALS WITH O BLOOD GROUP POSSIBLE EVOLUTIONARY SIGNIFICANCE
At the Matlab Hospital of the international Centre for Diarrhoeal Disease Research, Bangladesh, the authors examined the blood groups of patients hospitalized between January and September 1979 for diarrheal disease due to a variety of bacterial and viral agents. A significant association was identi...
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| Veröffentlicht in: | American journal of epidemiology 1985-06, Vol.121 (6), p.791-796 |
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| container_title | American journal of epidemiology |
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| creator | GLASS, ROGER I. HOLMGREN, JAN HALEY, CHARLES E. KHAN, M. R. SVENNERHOLM, ANNMARI STOLL, BARBARA J. HOSSAIN, K. M. BELAYET BLACK, ROBERT E. YUNUS, M. BARUA, DHIMAN |
| description | At the Matlab Hospital of the international Centre for Diarrhoeal Disease Research, Bangladesh, the authors examined the blood groups of patients hospitalized between January and September 1979 for diarrheal disease due to a variety of bacterial and viral agents. A significant association was identified only for cholera, in which cholera patients were twice as likely to have blood group O and one-ninth as likely to have blood group AB as community controls. A follow-up study of family contacts of cholera patients, carried out between September 1980 and July 1982, indicated that blood group did not affect an individual's risk of having a culture-proven infection with V. cholerae 01 but was directly related to the severity of disease. Individuals with the most severe diarrhea compared with those with asymptomatic infection were more often of blood group O(68% versus 36%, p < 0.01) and less often of AB (0% versus 7%, p < 0.01). It was not possible to identify the molecular basis for this genetically related protection using biologic models of cholera that are currently available. The constant selective pressure of cholera against people of O blood group may account in part for the extremely low prevalence of O group genes and the high prevalence of B group genes found among the people living in the Gangetic Delta. |
| doi_str_mv | 10.1093/oxfordjournals.aje.a114050 |
| format | Article |
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R. ; SVENNERHOLM, ANNMARI ; STOLL, BARBARA J. ; HOSSAIN, K. M. BELAYET ; BLACK, ROBERT E. ; YUNUS, M. ; BARUA, DHIMAN</creator><creatorcontrib>GLASS, ROGER I. ; HOLMGREN, JAN ; HALEY, CHARLES E. ; KHAN, M. R. ; SVENNERHOLM, ANNMARI ; STOLL, BARBARA J. ; HOSSAIN, K. M. BELAYET ; BLACK, ROBERT E. ; YUNUS, M. ; BARUA, DHIMAN</creatorcontrib><description>At the Matlab Hospital of the international Centre for Diarrhoeal Disease Research, Bangladesh, the authors examined the blood groups of patients hospitalized between January and September 1979 for diarrheal disease due to a variety of bacterial and viral agents. A significant association was identified only for cholera, in which cholera patients were twice as likely to have blood group O and one-ninth as likely to have blood group AB as community controls. A follow-up study of family contacts of cholera patients, carried out between September 1980 and July 1982, indicated that blood group did not affect an individual's risk of having a culture-proven infection with V. cholerae 01 but was directly related to the severity of disease. Individuals with the most severe diarrhea compared with those with asymptomatic infection were more often of blood group O(68% versus 36%, p < 0.01) and less often of AB (0% versus 7%, p < 0.01). It was not possible to identify the molecular basis for this genetically related protection using biologic models of cholera that are currently available. The constant selective pressure of cholera against people of O blood group may account in part for the extremely low prevalence of O group genes and the high prevalence of B group genes found among the people living in the Gangetic Delta.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/oxfordjournals.aje.a114050</identifier><identifier>PMID: 4014172</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>ABO Blood-Group System - genetics ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Bangladesh ; Biological and medical sciences ; Biological Evolution ; blood groups ; Cholera ; Cholera - blood ; Cholera - genetics ; diarrhea ; Diarrhea - blood ; Diarrhea - etiology ; Disease Susceptibility ; Human bacterial diseases ; Humans ; Infectious diseases ; Medical sciences ; Tropical bacterial diseases ; Tropical medicine ; Vibrio cholerae ; Vibrlo cholerae</subject><ispartof>American journal of epidemiology, 1985-06, Vol.121 (6), p.791-796</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-c57c12ab06e81ef79cca8969dd55beaf044f365d18d0e7cd35667c8af3484b263</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27848,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9130842$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4014172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GLASS, ROGER I.</creatorcontrib><creatorcontrib>HOLMGREN, JAN</creatorcontrib><creatorcontrib>HALEY, CHARLES E.</creatorcontrib><creatorcontrib>KHAN, M. R.</creatorcontrib><creatorcontrib>SVENNERHOLM, ANNMARI</creatorcontrib><creatorcontrib>STOLL, BARBARA J.</creatorcontrib><creatorcontrib>HOSSAIN, K. M. BELAYET</creatorcontrib><creatorcontrib>BLACK, ROBERT E.</creatorcontrib><creatorcontrib>YUNUS, M.</creatorcontrib><creatorcontrib>BARUA, DHIMAN</creatorcontrib><title>PREDISPOSITION FOR CHOLERA OF INDIVIDUALS WITH O BLOOD GROUP POSSIBLE EVOLUTIONARY SIGNIFICANCE</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>At the Matlab Hospital of the international Centre for Diarrhoeal Disease Research, Bangladesh, the authors examined the blood groups of patients hospitalized between January and September 1979 for diarrheal disease due to a variety of bacterial and viral agents. A significant association was identified only for cholera, in which cholera patients were twice as likely to have blood group O and one-ninth as likely to have blood group AB as community controls. A follow-up study of family contacts of cholera patients, carried out between September 1980 and July 1982, indicated that blood group did not affect an individual's risk of having a culture-proven infection with V. cholerae 01 but was directly related to the severity of disease. Individuals with the most severe diarrhea compared with those with asymptomatic infection were more often of blood group O(68% versus 36%, p < 0.01) and less often of AB (0% versus 7%, p < 0.01). It was not possible to identify the molecular basis for this genetically related protection using biologic models of cholera that are currently available. The constant selective pressure of cholera against people of O blood group may account in part for the extremely low prevalence of O group genes and the high prevalence of B group genes found among the people living in the Gangetic Delta.</description><subject>ABO Blood-Group System - genetics</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Bangladesh</subject><subject>Biological and medical sciences</subject><subject>Biological Evolution</subject><subject>blood groups</subject><subject>Cholera</subject><subject>Cholera - blood</subject><subject>Cholera - genetics</subject><subject>diarrhea</subject><subject>Diarrhea - blood</subject><subject>Diarrhea - etiology</subject><subject>Disease Susceptibility</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Tropical bacterial diseases</subject><subject>Tropical medicine</subject><subject>Vibrio cholerae</subject><subject>Vibrlo cholerae</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNqFkc2O0zAUhS0EGsrAIyBZgNil2I5_EnadNm0tQlySdvjZWK7jSO20zRC30szbj6uWSrBh5cX5zvXV_QB4h1EfozT-1D40bVev20O3MxvfN2vXNxhTxNAz0MNU8IgTxp-DHkKIRCnh5CV45f0aIYxThq7AFUWYYkF6QM_KbCSrmarkXKoCjlUJh1OVZ-UAqjGUxUjeytFikFfwu5xPoYI3uVIjOCnVYgZDrZI3eQazW5UvjgMG5U9YyUkhx3I4KIbZa_CiCTu6N-f3GizG2Xw4jXI1CUQeWUrRPrJMWEzMEnGXYNeI1FqTpDyta8aWzjSI0ibmrMZJjZywdcw4FzYxTUwTuiQ8vgYfT3Pvu_b3wfm93q68dZuN2bn24LXgOE0Jxf8Fw10YZUwE8P0_4J-DaxwjzhnBJAnU5xNlu9b7zjX6vlttTfeoMdJHWfpvWTrI0mdZofz2_MVhuXX1pXq2E_IP59x4azZNZ3Z25S9YGvZI6BGLTtjK793DJTbdneYiFkxPf_zSBfnyjZbzr7qKnwCpLKnE</recordid><startdate>198506</startdate><enddate>198506</enddate><creator>GLASS, ROGER I.</creator><creator>HOLMGREN, JAN</creator><creator>HALEY, CHARLES E.</creator><creator>KHAN, M. 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BELAYET</creator><creator>BLACK, ROBERT E.</creator><creator>YUNUS, M.</creator><creator>BARUA, DHIMAN</creator><general>Oxford University Press</general><general>School of Hygiene and Public Health of the Johns Hopkins University</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>HVZBN</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>198506</creationdate><title>PREDISPOSITION FOR CHOLERA OF INDIVIDUALS WITH O BLOOD GROUP POSSIBLE EVOLUTIONARY SIGNIFICANCE</title><author>GLASS, ROGER I. ; HOLMGREN, JAN ; HALEY, CHARLES E. ; KHAN, M. 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R.</au><au>SVENNERHOLM, ANNMARI</au><au>STOLL, BARBARA J.</au><au>HOSSAIN, K. M. BELAYET</au><au>BLACK, ROBERT E.</au><au>YUNUS, M.</au><au>BARUA, DHIMAN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PREDISPOSITION FOR CHOLERA OF INDIVIDUALS WITH O BLOOD GROUP POSSIBLE EVOLUTIONARY SIGNIFICANCE</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am J Epidemiol</addtitle><date>1985-06</date><risdate>1985</risdate><volume>121</volume><issue>6</issue><spage>791</spage><epage>796</epage><pages>791-796</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><coden>AJEPAS</coden><abstract>At the Matlab Hospital of the international Centre for Diarrhoeal Disease Research, Bangladesh, the authors examined the blood groups of patients hospitalized between January and September 1979 for diarrheal disease due to a variety of bacterial and viral agents. A significant association was identified only for cholera, in which cholera patients were twice as likely to have blood group O and one-ninth as likely to have blood group AB as community controls. A follow-up study of family contacts of cholera patients, carried out between September 1980 and July 1982, indicated that blood group did not affect an individual's risk of having a culture-proven infection with V. cholerae 01 but was directly related to the severity of disease. Individuals with the most severe diarrhea compared with those with asymptomatic infection were more often of blood group O(68% versus 36%, p < 0.01) and less often of AB (0% versus 7%, p < 0.01). It was not possible to identify the molecular basis for this genetically related protection using biologic models of cholera that are currently available. The constant selective pressure of cholera against people of O blood group may account in part for the extremely low prevalence of O group genes and the high prevalence of B group genes found among the people living in the Gangetic Delta.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>4014172</pmid><doi>10.1093/oxfordjournals.aje.a114050</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9262 |
| ispartof | American journal of epidemiology, 1985-06, Vol.121 (6), p.791-796 |
| issn | 0002-9262 1476-6256 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy; Periodicals Index Online |
| subjects | ABO Blood-Group System - genetics Bacterial diseases Bacterial diseases of the digestive system and abdomen Bangladesh Biological and medical sciences Biological Evolution blood groups Cholera Cholera - blood Cholera - genetics diarrhea Diarrhea - blood Diarrhea - etiology Disease Susceptibility Human bacterial diseases Humans Infectious diseases Medical sciences Tropical bacterial diseases Tropical medicine Vibrio cholerae Vibrlo cholerae |
| title | PREDISPOSITION FOR CHOLERA OF INDIVIDUALS WITH O BLOOD GROUP POSSIBLE EVOLUTIONARY SIGNIFICANCE |
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