SERUM SELENIUM AND THE RISK OF CORONARY HEART DISEASE AND STROKE
The association between serum selenium concentration and five-year risk of cardiovascular disease was studied in 1,110 men aged 55 to 74 years in two rural areas of Finland. In the total cohort, all-cause and cardiovascular deaths were associated significantly with serum selenium of less than 45 μg/...
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| Veröffentlicht in: | American journal of epidemiology 1985-08, Vol.122 (2), p.276-282 |
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| container_title | American journal of epidemiology |
| container_volume | 122 |
| creator | VIRTAMO, JARMO VALKEILA, ESKO ALFTHAN, GEORG PUNSAR, SVEN HUTTUNEN, JUSSI K. KARVONEN, MARTTI J. |
| description | The association between serum selenium concentration and five-year risk of cardiovascular disease was studied in 1,110 men aged 55 to 74 years in two rural areas of Finland. In the total cohort, all-cause and cardiovascular deaths were associated significantly with serum selenium of less than 45 μg/liter, an adjusted relative risk of 1.4 (95% confidence interval (Cl), 1.0–2.0, p |
| doi_str_mv | 10.1093/oxfordjournals.aje.a114099 |
| format | Article |
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In the total cohort, all-cause and cardiovascular deaths were associated significantly with serum selenium of less than 45 μg/liter, an adjusted relative risk of 1.4 (95% confidence interval (Cl), 1.0–2.0, p<0.05) and 1.6 (957percnt; Cl, 1.1–2.3, p<0.05), respectively. Among men free of coronary heart disease at the outset, these associations were of similar magnitude but did not attain statistical significance. Among men free of stroke at the outset, low serum selenium was associated significantly with stroke mortality, an adjusted relative risk of 3.7 (95% Cl, 1.0–13.1). The associations of coronary deaths and myocardial infarctions with low serum selenium were nonsignificant.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/oxfordjournals.aje.a114099</identifier><identifier>PMID: 4014210</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Aged ; Anthropometry ; Biological and medical sciences ; Blood Pressure ; Cardiology. Vascular system ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - mortality ; cerebrovascular disorders ; Cholesterol - blood ; coronary disease ; Coronary Disease - blood ; Coronary Disease - mortality ; Coronary heart disease ; Epidemiologic Methods ; Finland ; Follow-Up Studies ; Heart ; Humans ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - blood ; Myocardial Infarction - mortality ; Regression Analysis ; Risk ; Rural Population ; selenium ; Selenium - blood</subject><ispartof>American journal of epidemiology, 1985-08, Vol.122 (2), p.276-282</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-870d147108c134d8d79eecaf11a97f54046e2cca762e336ffd90b31257e714c03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27869,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9219019$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4014210$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VIRTAMO, JARMO</creatorcontrib><creatorcontrib>VALKEILA, ESKO</creatorcontrib><creatorcontrib>ALFTHAN, GEORG</creatorcontrib><creatorcontrib>PUNSAR, SVEN</creatorcontrib><creatorcontrib>HUTTUNEN, JUSSI K.</creatorcontrib><creatorcontrib>KARVONEN, MARTTI J.</creatorcontrib><title>SERUM SELENIUM AND THE RISK OF CORONARY HEART DISEASE AND STROKE</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>The association between serum selenium concentration and five-year risk of cardiovascular disease was studied in 1,110 men aged 55 to 74 years in two rural areas of Finland. In the total cohort, all-cause and cardiovascular deaths were associated significantly with serum selenium of less than 45 μg/liter, an adjusted relative risk of 1.4 (95% confidence interval (Cl), 1.0–2.0, p<0.05) and 1.6 (957percnt; Cl, 1.1–2.3, p<0.05), respectively. Among men free of coronary heart disease at the outset, these associations were of similar magnitude but did not attain statistical significance. Among men free of stroke at the outset, low serum selenium was associated significantly with stroke mortality, an adjusted relative risk of 3.7 (95% Cl, 1.0–13.1). The associations of coronary deaths and myocardial infarctions with low serum selenium were nonsignificant.</description><subject>Aged</subject><subject>Anthropometry</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - mortality</subject><subject>cerebrovascular disorders</subject><subject>Cholesterol - blood</subject><subject>coronary disease</subject><subject>Coronary Disease - blood</subject><subject>Coronary Disease - mortality</subject><subject>Coronary heart disease</subject><subject>Epidemiologic Methods</subject><subject>Finland</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - mortality</subject><subject>Regression Analysis</subject><subject>Risk</subject><subject>Rural Population</subject><subject>selenium</subject><subject>Selenium - blood</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNpdkNGKEzEUhoMoa3f1EYRBxbup5yQzSeOVQ5vasrUDM11Qb0I2k4HWtrMmLey-vakdC3qVA-c7f34-Qt4iDBEk-9g9tp1vNt3R7802DM3GDQ1iBlI-IwPMBE85zflzMgAAmkrK6UtyHcIGAFHmcEWuMsCMIgzI51pVd1-TWi3Uch6HYjlJVjOVVPP6NimnybisymVRfU9mqqhWyWReq6JWf7B6VZW36hV50cYS7nX_3pC7qVqNZ-mi_DIfF4vUxl6HdCSgic0QRhZZ1owaIZ2zpkU0UrR5Bhl31FojOHWM8bZtJNwzpLlwAjML7IZ8OOc--O7X0YWD3q2Dddut2bvuGLTgKDnlMoLv_gP_itLIgPM8ujnFfTpT1ncheNfqB7_eGf-kEfRJsv5Xso6SdS85Hr_pvzje71xzOe2txv37fm-CNdvWm71dhwsmKUrAU0x6xtbh4B4va-N_ai6YyPXs2w-dyQmb5osqlv8NSoqSHg</recordid><startdate>198508</startdate><enddate>198508</enddate><creator>VIRTAMO, JARMO</creator><creator>VALKEILA, ESKO</creator><creator>ALFTHAN, GEORG</creator><creator>PUNSAR, SVEN</creator><creator>HUTTUNEN, JUSSI K.</creator><creator>KARVONEN, MARTTI J.</creator><general>Oxford University Press</general><general>School of Hygiene and Public Health of the Johns Hopkins University</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>HVZBN</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>7X8</scope></search><sort><creationdate>198508</creationdate><title>SERUM SELENIUM AND THE RISK OF CORONARY HEART DISEASE AND STROKE</title><author>VIRTAMO, JARMO ; VALKEILA, ESKO ; ALFTHAN, GEORG ; PUNSAR, SVEN ; HUTTUNEN, JUSSI K. ; KARVONEN, MARTTI J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-870d147108c134d8d79eecaf11a97f54046e2cca762e336ffd90b31257e714c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Aged</topic><topic>Anthropometry</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Cardiology. 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In the total cohort, all-cause and cardiovascular deaths were associated significantly with serum selenium of less than 45 μg/liter, an adjusted relative risk of 1.4 (95% confidence interval (Cl), 1.0–2.0, p<0.05) and 1.6 (957percnt; Cl, 1.1–2.3, p<0.05), respectively. Among men free of coronary heart disease at the outset, these associations were of similar magnitude but did not attain statistical significance. Among men free of stroke at the outset, low serum selenium was associated significantly with stroke mortality, an adjusted relative risk of 3.7 (95% Cl, 1.0–13.1). The associations of coronary deaths and myocardial infarctions with low serum selenium were nonsignificant.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>4014210</pmid><doi>10.1093/oxfordjournals.aje.a114099</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0002-9262 |
| ispartof | American journal of epidemiology, 1985-08, Vol.122 (2), p.276-282 |
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| language | eng |
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| source | Oxford University Press Journals Digital Archive legacy; MEDLINE; Periodicals Index Online |
| subjects | Aged Anthropometry Biological and medical sciences Blood Pressure Cardiology. Vascular system Cardiovascular Diseases - blood Cardiovascular Diseases - mortality cerebrovascular disorders Cholesterol - blood coronary disease Coronary Disease - blood Coronary Disease - mortality Coronary heart disease Epidemiologic Methods Finland Follow-Up Studies Heart Humans Male Medical sciences Middle Aged Myocardial Infarction - blood Myocardial Infarction - mortality Regression Analysis Risk Rural Population selenium Selenium - blood |
| title | SERUM SELENIUM AND THE RISK OF CORONARY HEART DISEASE AND STROKE |
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