Evidence that bombesin releases extragastric gastrin in man
Bombesin-induced gastrin release from extragastric sources has been investigated in two groups of patients without gastric antrum: 11 patients with total gastrectomy and 11 patients with subtotal (Billroth II) gastrectomy. A 30-min bombesin infusion (5 ng · kg −1 · min −1) caused a prompt significan...
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| Veröffentlicht in: | Regulatory peptides 1985-05, Vol.11 (1), p.43-49 |
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| creator | Annibale, Bruno Corleto, Vito Severi, Carola de Magistris, Laura De Toma, Giorgio Delle Fave, Gianfranco |
| description | Bombesin-induced gastrin release from extragastric sources has been investigated in two groups of patients without gastric antrum: 11 patients with total gastrectomy and 11 patients with subtotal (Billroth II) gastrectomy. A 30-min bombesin infusion (5 ng · kg
−1 · min
−1) caused a prompt significant gastrin increase (
P < 0.05) in both groups of patients. The gastrin response to bombesin was significantly (
P < 0.005) lower in patients without antral tissue than in the control group (
n = 7). The individual peak gastrin responses, in totally (TG) and subtotally (SG) gastrectomized patients, were significantly over basal levels (TG: peak 100.3 ± 12 vs. basal 62.8 ± 9.1,
P < 0.005; SG: peak 96.9 ± 9.4 vs. basal 72.4 ± 6.8,
P < 0.001; pg/ml, mean ± S.E.M.). These data indicate that bombesin acts not only on antral G cells, but on all gastrin cells in the gastrointestinal tract. |
| doi_str_mv | 10.1016/0167-0115(85)90030-8 |
| format | Article |
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−1 · min
−1) caused a prompt significant gastrin increase (
P < 0.05) in both groups of patients. The gastrin response to bombesin was significantly (
P < 0.005) lower in patients without antral tissue than in the control group (
n = 7). The individual peak gastrin responses, in totally (TG) and subtotally (SG) gastrectomized patients, were significantly over basal levels (TG: peak 100.3 ± 12 vs. basal 62.8 ± 9.1,
P < 0.005; SG: peak 96.9 ± 9.4 vs. basal 72.4 ± 6.8,
P < 0.001; pg/ml, mean ± S.E.M.). These data indicate that bombesin acts not only on antral G cells, but on all gastrin cells in the gastrointestinal tract.</description><identifier>ISSN: 0167-0115</identifier><identifier>EISSN: 1873-1686</identifier><identifier>DOI: 10.1016/0167-0115(85)90030-8</identifier><identifier>PMID: 4011955</identifier><identifier>CODEN: REPPDY</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Adult ; Aged ; Biological and medical sciences ; bombesin ; Bombesin - pharmacology ; Female ; Fundamental and applied biological sciences. Psychology ; Gastrectomy ; Gastric Mucosa - metabolism ; gastrin release ; Gastrins - metabolism ; Gastrointestinal hormones ; Humans ; Male ; Middle Aged ; Peptides - pharmacology ; Postoperative Period ; Pyloric Antrum - drug effects ; Pyloric Antrum - metabolism ; Pyloric Antrum - surgery ; total gastrectomy ; Vertebrates: digestive system</subject><ispartof>Regulatory peptides, 1985-05, Vol.11 (1), p.43-49</ispartof><rights>1985</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-1a1810756bb04a2532ed095de5772c152753454f7f35d4759d1c27cddd467a7c3</citedby><cites>FETCH-LOGICAL-c386t-1a1810756bb04a2532ed095de5772c152753454f7f35d4759d1c27cddd467a7c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0167-0115(85)90030-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9208359$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4011955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Annibale, Bruno</creatorcontrib><creatorcontrib>Corleto, Vito</creatorcontrib><creatorcontrib>Severi, Carola</creatorcontrib><creatorcontrib>de Magistris, Laura</creatorcontrib><creatorcontrib>De Toma, Giorgio</creatorcontrib><creatorcontrib>Delle Fave, Gianfranco</creatorcontrib><title>Evidence that bombesin releases extragastric gastrin in man</title><title>Regulatory peptides</title><addtitle>Regul Pept</addtitle><description>Bombesin-induced gastrin release from extragastric sources has been investigated in two groups of patients without gastric antrum: 11 patients with total gastrectomy and 11 patients with subtotal (Billroth II) gastrectomy. A 30-min bombesin infusion (5 ng · kg
−1 · min
−1) caused a prompt significant gastrin increase (
P < 0.05) in both groups of patients. The gastrin response to bombesin was significantly (
P < 0.005) lower in patients without antral tissue than in the control group (
n = 7). The individual peak gastrin responses, in totally (TG) and subtotally (SG) gastrectomized patients, were significantly over basal levels (TG: peak 100.3 ± 12 vs. basal 62.8 ± 9.1,
P < 0.005; SG: peak 96.9 ± 9.4 vs. basal 72.4 ± 6.8,
P < 0.001; pg/ml, mean ± S.E.M.). These data indicate that bombesin acts not only on antral G cells, but on all gastrin cells in the gastrointestinal tract.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>bombesin</subject><subject>Bombesin - pharmacology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastrectomy</subject><subject>Gastric Mucosa - metabolism</subject><subject>gastrin release</subject><subject>Gastrins - metabolism</subject><subject>Gastrointestinal hormones</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Peptides - pharmacology</subject><subject>Postoperative Period</subject><subject>Pyloric Antrum - drug effects</subject><subject>Pyloric Antrum - metabolism</subject><subject>Pyloric Antrum - surgery</subject><subject>total gastrectomy</subject><subject>Vertebrates: digestive system</subject><issn>0167-0115</issn><issn>1873-1686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAQgIMo67r6DxR6ENFDNWmaRxEEWdYHLHjRc0iTqUb6WJPuov_e1C57FGYYmPlmGD6ETgm-Jpjwm5gixYSwS8muCowpTuUemhIpaEq45PtoukMO0VEInxgTJgSdoEkemwVjU3S72DgLrYGk_9B9UnZNCcG1iYcadICQwHfv9bsOvXcmGWubxGh0e4wOKl0HONnWGXp7WLzOn9Lly-Pz_H6ZGip5nxJNJMGC8bLEuc4YzcDiglmIv2SGsEwwmrO8EhVlNhessMRkwlhrcy60MHSGLsa7K999rSH0qnHBQF3rFrp1UIKTgmMiI5iPoPFdCB4qtfKu0f5HEawGZ2oQogYhSjL150wNa2fb--uyAbtb2kqK8_PtXAej68rr1riww4oMS8qKiN2NGEQXGwdeBeMGtdZ5ML2ynfv_j1_jEIYa</recordid><startdate>198505</startdate><enddate>198505</enddate><creator>Annibale, Bruno</creator><creator>Corleto, Vito</creator><creator>Severi, Carola</creator><creator>de Magistris, Laura</creator><creator>De Toma, Giorgio</creator><creator>Delle Fave, Gianfranco</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198505</creationdate><title>Evidence that bombesin releases extragastric gastrin in man</title><author>Annibale, Bruno ; Corleto, Vito ; Severi, Carola ; de Magistris, Laura ; De Toma, Giorgio ; Delle Fave, Gianfranco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-1a1810756bb04a2532ed095de5772c152753454f7f35d4759d1c27cddd467a7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>bombesin</topic><topic>Bombesin - pharmacology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastrectomy</topic><topic>Gastric Mucosa - metabolism</topic><topic>gastrin release</topic><topic>Gastrins - metabolism</topic><topic>Gastrointestinal hormones</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Peptides - pharmacology</topic><topic>Postoperative Period</topic><topic>Pyloric Antrum - drug effects</topic><topic>Pyloric Antrum - metabolism</topic><topic>Pyloric Antrum - surgery</topic><topic>total gastrectomy</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Annibale, Bruno</creatorcontrib><creatorcontrib>Corleto, Vito</creatorcontrib><creatorcontrib>Severi, Carola</creatorcontrib><creatorcontrib>de Magistris, Laura</creatorcontrib><creatorcontrib>De Toma, Giorgio</creatorcontrib><creatorcontrib>Delle Fave, Gianfranco</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Regulatory peptides</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Annibale, Bruno</au><au>Corleto, Vito</au><au>Severi, Carola</au><au>de Magistris, Laura</au><au>De Toma, Giorgio</au><au>Delle Fave, Gianfranco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence that bombesin releases extragastric gastrin in man</atitle><jtitle>Regulatory peptides</jtitle><addtitle>Regul Pept</addtitle><date>1985-05</date><risdate>1985</risdate><volume>11</volume><issue>1</issue><spage>43</spage><epage>49</epage><pages>43-49</pages><issn>0167-0115</issn><eissn>1873-1686</eissn><coden>REPPDY</coden><abstract>Bombesin-induced gastrin release from extragastric sources has been investigated in two groups of patients without gastric antrum: 11 patients with total gastrectomy and 11 patients with subtotal (Billroth II) gastrectomy. A 30-min bombesin infusion (5 ng · kg
−1 · min
−1) caused a prompt significant gastrin increase (
P < 0.05) in both groups of patients. The gastrin response to bombesin was significantly (
P < 0.005) lower in patients without antral tissue than in the control group (
n = 7). The individual peak gastrin responses, in totally (TG) and subtotally (SG) gastrectomized patients, were significantly over basal levels (TG: peak 100.3 ± 12 vs. basal 62.8 ± 9.1,
P < 0.005; SG: peak 96.9 ± 9.4 vs. basal 72.4 ± 6.8,
P < 0.001; pg/ml, mean ± S.E.M.). These data indicate that bombesin acts not only on antral G cells, but on all gastrin cells in the gastrointestinal tract.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>4011955</pmid><doi>10.1016/0167-0115(85)90030-8</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Aged Biological and medical sciences bombesin Bombesin - pharmacology Female Fundamental and applied biological sciences. Psychology Gastrectomy Gastric Mucosa - metabolism gastrin release Gastrins - metabolism Gastrointestinal hormones Humans Male Middle Aged Peptides - pharmacology Postoperative Period Pyloric Antrum - drug effects Pyloric Antrum - metabolism Pyloric Antrum - surgery total gastrectomy Vertebrates: digestive system |
| title | Evidence that bombesin releases extragastric gastrin in man |
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