Binding of 3H-spiperone to human lymphocytes: A biological marker in schizophrenia?
The specific binding of the dopamine antagonist 3H-spiperone to lymphocytes from a healthy control group ( n = 40), a group of acute, unmedicated schizophrenic patients ( n = 27), and a psychiatric control group ( n = 16) was investigated. There were no differences in binding parameters between the...
Gespeichert in:
| Veröffentlicht in: | Psychiatry research 1985-05, Vol.15 (1), p.41-48 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 48 |
|---|---|
| container_issue | 1 |
| container_start_page | 41 |
| container_title | Psychiatry research |
| container_volume | 15 |
| creator | Bondy, Brigitta Ackenheil, Manfred Elbers, Rembert Fröhler, Manfred |
| description | The specific binding of the dopamine antagonist
3H-spiperone to lymphocytes from a healthy control group (
n = 40), a group of acute, unmedicated schizophrenic patients (
n = 27), and a psychiatric control group (
n = 16) was investigated. There were no differences in binding parameters between the healthy controls (
B
max 2.6 ± 0.7 fmoles/10
6 cells;
K
d 0.17 ± 0.07 n
M) and the psychiatric controls group. Binding capacity of
3H-spiperone was significantly incresed in lymphocytes from the schizophrenic patients (
B
max 14.4 ± 9.3 fmoles/10
6 cells). Moreover, a slight decrease in affinity was observed (
K
d 0.44 ± 0.21 n
M). Because the increase in binding appeared only in schizophrenic patients, this peripheral model could prove valuable as a diagnostic criterion. |
| doi_str_mv | 10.1016/0165-1781(85)90038-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76190450</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0165178185900381</els_id><sourcerecordid>76190450</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2338-c8f925bf126a25551f066cae9e48164e0b1d1cf78222fdbe80cc939f7960a773</originalsourceid><addsrcrecordid>eNp9kMFu1DAQhi0EKtuWNwDJB4TaQ8DjxInNAdRWhSJV6oHeLccZdw2Jndq7lbZPj7e72iOH0Rzmm1-_PkLeA_sMDNovZUQFnYQzKc4VY7Ws4BVZgOx41QGvX5PFAXlLjnP-wxjjoNQROeINU6KVC_L70ofBhwcaHa1vqjz7GVMMSFeRLteTCXTcTPMy2s0K81d6QXsfx_jgrRnpZNJfTNQHmu3SP8d5mTB48_2UvHFmzPhuv0_I_Y_r-6ub6vbu56-ri9vK8rqUtdIpLnoHvDVcCAGOta01qLCR0DbIehjAuk5yzt3Qo2TWqlq5TrXMdF19Qj7tYucUH9eYV3ry2eI4moBxnXXXgmKNYAVsdqBNMeeETs_Jl_IbDUxvVeqtJ731pKXQLyo1lLcP-_x1P-FweNq7K_eP-7vJRYdLJlifD5iU28C6YN92GBYVTx6TztZjsDj4hHalh-j_3-Mffb-Osg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76190450</pqid></control><display><type>article</type><title>Binding of 3H-spiperone to human lymphocytes: A biological marker in schizophrenia?</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Bondy, Brigitta ; Ackenheil, Manfred ; Elbers, Rembert ; Fröhler, Manfred</creator><creatorcontrib>Bondy, Brigitta ; Ackenheil, Manfred ; Elbers, Rembert ; Fröhler, Manfred</creatorcontrib><description>The specific binding of the dopamine antagonist
3H-spiperone to lymphocytes from a healthy control group (
n = 40), a group of acute, unmedicated schizophrenic patients (
n = 27), and a psychiatric control group (
n = 16) was investigated. There were no differences in binding parameters between the healthy controls (
B
max 2.6 ± 0.7 fmoles/10
6 cells;
K
d 0.17 ± 0.07 n
M) and the psychiatric controls group. Binding capacity of
3H-spiperone was significantly incresed in lymphocytes from the schizophrenic patients (
B
max 14.4 ± 9.3 fmoles/10
6 cells). Moreover, a slight decrease in affinity was observed (
K
d 0.44 ± 0.21 n
M). Because the increase in binding appeared only in schizophrenic patients, this peripheral model could prove valuable as a diagnostic criterion.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/0165-1781(85)90038-1</identifier><identifier>PMID: 2409568</identifier><identifier>CODEN: PSRSDR</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>3H-spiperone ; Acute Disease ; Adult ; B-Lymphocytes - metabolism ; Binding Sites ; Biological and medical sciences ; Butaclamol - metabolism ; Butyrophenones - metabolism ; Female ; Humans ; lymphocytes ; Lymphocytes - metabolism ; Male ; Medical sciences ; Miscellaneous ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; schizophrenia ; Schizophrenia - blood ; specific binding ; Spiperone - metabolism ; T-Lymphocytes - metabolism ; Techniques and methods</subject><ispartof>Psychiatry research, 1985-05, Vol.15 (1), p.41-48</ispartof><rights>1985</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2338-c8f925bf126a25551f066cae9e48164e0b1d1cf78222fdbe80cc939f7960a773</citedby><cites>FETCH-LOGICAL-c2338-c8f925bf126a25551f066cae9e48164e0b1d1cf78222fdbe80cc939f7960a773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0165178185900381$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8817813$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2409568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bondy, Brigitta</creatorcontrib><creatorcontrib>Ackenheil, Manfred</creatorcontrib><creatorcontrib>Elbers, Rembert</creatorcontrib><creatorcontrib>Fröhler, Manfred</creatorcontrib><title>Binding of 3H-spiperone to human lymphocytes: A biological marker in schizophrenia?</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>The specific binding of the dopamine antagonist
3H-spiperone to lymphocytes from a healthy control group (
n = 40), a group of acute, unmedicated schizophrenic patients (
n = 27), and a psychiatric control group (
n = 16) was investigated. There were no differences in binding parameters between the healthy controls (
B
max 2.6 ± 0.7 fmoles/10
6 cells;
K
d 0.17 ± 0.07 n
M) and the psychiatric controls group. Binding capacity of
3H-spiperone was significantly incresed in lymphocytes from the schizophrenic patients (
B
max 14.4 ± 9.3 fmoles/10
6 cells). Moreover, a slight decrease in affinity was observed (
K
d 0.44 ± 0.21 n
M). Because the increase in binding appeared only in schizophrenic patients, this peripheral model could prove valuable as a diagnostic criterion.</description><subject>3H-spiperone</subject><subject>Acute Disease</subject><subject>Adult</subject><subject>B-Lymphocytes - metabolism</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>Butaclamol - metabolism</subject><subject>Butyrophenones - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>lymphocytes</subject><subject>Lymphocytes - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>schizophrenia</subject><subject>Schizophrenia - blood</subject><subject>specific binding</subject><subject>Spiperone - metabolism</subject><subject>T-Lymphocytes - metabolism</subject><subject>Techniques and methods</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAQhi0EKtuWNwDJB4TaQ8DjxInNAdRWhSJV6oHeLccZdw2Jndq7lbZPj7e72iOH0Rzmm1-_PkLeA_sMDNovZUQFnYQzKc4VY7Ws4BVZgOx41QGvX5PFAXlLjnP-wxjjoNQROeINU6KVC_L70ofBhwcaHa1vqjz7GVMMSFeRLteTCXTcTPMy2s0K81d6QXsfx_jgrRnpZNJfTNQHmu3SP8d5mTB48_2UvHFmzPhuv0_I_Y_r-6ub6vbu56-ri9vK8rqUtdIpLnoHvDVcCAGOta01qLCR0DbIehjAuk5yzt3Qo2TWqlq5TrXMdF19Qj7tYucUH9eYV3ry2eI4moBxnXXXgmKNYAVsdqBNMeeETs_Jl_IbDUxvVeqtJ731pKXQLyo1lLcP-_x1P-FweNq7K_eP-7vJRYdLJlifD5iU28C6YN92GBYVTx6TztZjsDj4hHalh-j_3-Mffb-Osg</recordid><startdate>198505</startdate><enddate>198505</enddate><creator>Bondy, Brigitta</creator><creator>Ackenheil, Manfred</creator><creator>Elbers, Rembert</creator><creator>Fröhler, Manfred</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198505</creationdate><title>Binding of 3H-spiperone to human lymphocytes: A biological marker in schizophrenia?</title><author>Bondy, Brigitta ; Ackenheil, Manfred ; Elbers, Rembert ; Fröhler, Manfred</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2338-c8f925bf126a25551f066cae9e48164e0b1d1cf78222fdbe80cc939f7960a773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>3H-spiperone</topic><topic>Acute Disease</topic><topic>Adult</topic><topic>B-Lymphocytes - metabolism</topic><topic>Binding Sites</topic><topic>Biological and medical sciences</topic><topic>Butaclamol - metabolism</topic><topic>Butyrophenones - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>lymphocytes</topic><topic>Lymphocytes - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>schizophrenia</topic><topic>Schizophrenia - blood</topic><topic>specific binding</topic><topic>Spiperone - metabolism</topic><topic>T-Lymphocytes - metabolism</topic><topic>Techniques and methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bondy, Brigitta</creatorcontrib><creatorcontrib>Ackenheil, Manfred</creatorcontrib><creatorcontrib>Elbers, Rembert</creatorcontrib><creatorcontrib>Fröhler, Manfred</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bondy, Brigitta</au><au>Ackenheil, Manfred</au><au>Elbers, Rembert</au><au>Fröhler, Manfred</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Binding of 3H-spiperone to human lymphocytes: A biological marker in schizophrenia?</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>1985-05</date><risdate>1985</risdate><volume>15</volume><issue>1</issue><spage>41</spage><epage>48</epage><pages>41-48</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><coden>PSRSDR</coden><abstract>The specific binding of the dopamine antagonist
3H-spiperone to lymphocytes from a healthy control group (
n = 40), a group of acute, unmedicated schizophrenic patients (
n = 27), and a psychiatric control group (
n = 16) was investigated. There were no differences in binding parameters between the healthy controls (
B
max 2.6 ± 0.7 fmoles/10
6 cells;
K
d 0.17 ± 0.07 n
M) and the psychiatric controls group. Binding capacity of
3H-spiperone was significantly incresed in lymphocytes from the schizophrenic patients (
B
max 14.4 ± 9.3 fmoles/10
6 cells). Moreover, a slight decrease in affinity was observed (
K
d 0.44 ± 0.21 n
M). Because the increase in binding appeared only in schizophrenic patients, this peripheral model could prove valuable as a diagnostic criterion.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>2409568</pmid><doi>10.1016/0165-1781(85)90038-1</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-1781 |
| ispartof | Psychiatry research, 1985-05, Vol.15 (1), p.41-48 |
| issn | 0165-1781 1872-7123 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76190450 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 3H-spiperone Acute Disease Adult B-Lymphocytes - metabolism Binding Sites Biological and medical sciences Butaclamol - metabolism Butyrophenones - metabolism Female Humans lymphocytes Lymphocytes - metabolism Male Medical sciences Miscellaneous Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry schizophrenia Schizophrenia - blood specific binding Spiperone - metabolism T-Lymphocytes - metabolism Techniques and methods |
| title | Binding of 3H-spiperone to human lymphocytes: A biological marker in schizophrenia? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T17%3A39%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Binding%20of%203H-spiperone%20to%20human%20lymphocytes:%20A%20biological%20marker%20in%20schizophrenia?&rft.jtitle=Psychiatry%20research&rft.au=Bondy,%20Brigitta&rft.date=1985-05&rft.volume=15&rft.issue=1&rft.spage=41&rft.epage=48&rft.pages=41-48&rft.issn=0165-1781&rft.eissn=1872-7123&rft.coden=PSRSDR&rft_id=info:doi/10.1016/0165-1781(85)90038-1&rft_dat=%3Cproquest_cross%3E76190450%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76190450&rft_id=info:pmid/2409568&rft_els_id=0165178185900381&rfr_iscdi=true |