Autoradiographic localization of kappa opiate receptors in CNS taste and feeding areas
Recent evidence suggests that kappa opiate receptors may play a key role in the regulation of appetite [21]. Such evidence implies that kappa receptors might be localized within specific brain areas known to regulate ingestive behaviors. On the basis of this implication we employed an in vitro film...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1985-05, Vol.22 (5), p.699-705 |
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| container_title | Pharmacology, biochemistry and behavior |
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| creator | Lynch, Wesley C. Watt, John Krall, Susan Paden, Charles M. |
| description | Recent evidence suggests that kappa opiate receptors may play a key role in the regulation of appetite [21]. Such evidence implies that kappa receptors might be localized within specific brain areas known to regulate ingestive behaviors. On the basis of this implication we employed an
in vitro film autoradiographic technique using
3H-ethylketocyclazozine as ligand to identify putative kappa receptors [7] within CNS “taste” nuclei [23] and surrounding areas. Coronal cryostat sections of rat brain were incubated with ligand in the presence of D-Ala
2, D-Leu
5-enkephalin (DADLE) and morphine, apposed to LKB Ultrofilm for 60 days, processed and kappa receptor densities evaluated with the aid of a hand held photometer and video image analyzer. Highest kappa receptor densities were found within various gustatory and feeding sites including the rostral pole of the nucleus of the solitary tract, parabrachial nuclei, ventral posterior and medial portions of the thalamus, medial hypothalamus, medial nuclei of the amygdala and bed nucleus of the stria terminalis. Various other midline and medial limbic areas also showed significant kappa densities. |
| doi_str_mv | 10.1016/0091-3057(85)90516-7 |
| format | Article |
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in vitro film autoradiographic technique using
3H-ethylketocyclazozine as ligand to identify putative kappa receptors [7] within CNS “taste” nuclei [23] and surrounding areas. Coronal cryostat sections of rat brain were incubated with ligand in the presence of D-Ala
2, D-Leu
5-enkephalin (DADLE) and morphine, apposed to LKB Ultrofilm for 60 days, processed and kappa receptor densities evaluated with the aid of a hand held photometer and video image analyzer. Highest kappa receptor densities were found within various gustatory and feeding sites including the rostral pole of the nucleus of the solitary tract, parabrachial nuclei, ventral posterior and medial portions of the thalamus, medial hypothalamus, medial nuclei of the amygdala and bed nucleus of the stria terminalis. Various other midline and medial limbic areas also showed significant kappa densities.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/0091-3057(85)90516-7</identifier><identifier>PMID: 2989940</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>3H-ethylketocyclazocine ; Analgesics ; Animals ; Appetite ; Autoradiography ; Binding, Competitive ; Biological and medical sciences ; Brain - metabolism ; Corpus Striatum - metabolism ; Cyclazocine - analogs & derivatives ; Cyclazocine - metabolism ; Drinking ; Enkephalin, Leucine - analogs & derivatives ; Enkephalin, Leucine - metabolism ; Enkephalin, Leucine-2-Alanine ; Ethylketocyclazocine ; Feeding ; Feeding Behavior - physiology ; Film autoradiography ; Gustatory neuroanatomy ; Kappa opiate receptors ; Limbic System - metabolism ; Male ; Medical sciences ; Morphine - metabolism ; Neuropharmacology ; Pharmacology. Drug treatments ; Rats ; Receptors, Opioid - metabolism ; Receptors, Opioid, kappa ; Taste - physiology ; Taste preference</subject><ispartof>Pharmacology, biochemistry and behavior, 1985-05, Vol.22 (5), p.699-705</ispartof><rights>1985</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-31631815be13db2138c8c8dbd2d5727d0952d955b09acde3789f6aae10f162743</citedby><cites>FETCH-LOGICAL-c386t-31631815be13db2138c8c8dbd2d5727d0952d955b09acde3789f6aae10f162743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0091-3057(85)90516-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8401180$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2989940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lynch, Wesley C.</creatorcontrib><creatorcontrib>Watt, John</creatorcontrib><creatorcontrib>Krall, Susan</creatorcontrib><creatorcontrib>Paden, Charles M.</creatorcontrib><title>Autoradiographic localization of kappa opiate receptors in CNS taste and feeding areas</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Recent evidence suggests that kappa opiate receptors may play a key role in the regulation of appetite [21]. Such evidence implies that kappa receptors might be localized within specific brain areas known to regulate ingestive behaviors. On the basis of this implication we employed an
in vitro film autoradiographic technique using
3H-ethylketocyclazozine as ligand to identify putative kappa receptors [7] within CNS “taste” nuclei [23] and surrounding areas. Coronal cryostat sections of rat brain were incubated with ligand in the presence of D-Ala
2, D-Leu
5-enkephalin (DADLE) and morphine, apposed to LKB Ultrofilm for 60 days, processed and kappa receptor densities evaluated with the aid of a hand held photometer and video image analyzer. Highest kappa receptor densities were found within various gustatory and feeding sites including the rostral pole of the nucleus of the solitary tract, parabrachial nuclei, ventral posterior and medial portions of the thalamus, medial hypothalamus, medial nuclei of the amygdala and bed nucleus of the stria terminalis. Various other midline and medial limbic areas also showed significant kappa densities.</description><subject>3H-ethylketocyclazocine</subject><subject>Analgesics</subject><subject>Animals</subject><subject>Appetite</subject><subject>Autoradiography</subject><subject>Binding, Competitive</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Corpus Striatum - metabolism</subject><subject>Cyclazocine - analogs & derivatives</subject><subject>Cyclazocine - metabolism</subject><subject>Drinking</subject><subject>Enkephalin, Leucine - analogs & derivatives</subject><subject>Enkephalin, Leucine - metabolism</subject><subject>Enkephalin, Leucine-2-Alanine</subject><subject>Ethylketocyclazocine</subject><subject>Feeding</subject><subject>Feeding Behavior - physiology</subject><subject>Film autoradiography</subject><subject>Gustatory neuroanatomy</subject><subject>Kappa opiate receptors</subject><subject>Limbic System - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Morphine - metabolism</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Receptors, Opioid - metabolism</subject><subject>Receptors, Opioid, kappa</subject><subject>Taste - physiology</subject><subject>Taste preference</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoO4rOPqP1DIQUQPranuTie5LCyDHwvLevDjGqqT6jXa02mTHkF_vWlnmONSh4Kq5y2Kh7FnIN6AgO6tEAaqRkj1SsvXRkjoKvWAbUCrppKg1EO2OSGP2OOcfwgh2rpT5-y8NtqYVmzYt6v9EhP6EO8Szt-D42N0OIa_uIQ48TjwnzjPyOMccCGeyNFcApmHiW9vP_MFcxnj5PlA5MN0xzER5ifsbMAx09Njv2Bf37_7sv1Y3Xz6cL29uqlco7ulaqBrQIPsCRrf19BoV8r3vvZS1coLI2tvpOyFQeepUdoMHSKBGKCrVdtcsJeHu3OKv_aUF7sL2dE44kRxn63qig4BK9geQJdizokGO6eww_THgrCrTru6sqsrq6X9r9OqEnt-vL_vd-RPoaO_sn9x3GMu2oaEkwv5hOlWAOgVuzxgVFz8DpRsdoEmV4wVo4v1Mdz_xz-_IZBp</recordid><startdate>198505</startdate><enddate>198505</enddate><creator>Lynch, Wesley C.</creator><creator>Watt, John</creator><creator>Krall, Susan</creator><creator>Paden, Charles M.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198505</creationdate><title>Autoradiographic localization of kappa opiate receptors in CNS taste and feeding areas</title><author>Lynch, Wesley C. ; Watt, John ; Krall, Susan ; Paden, Charles M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-31631815be13db2138c8c8dbd2d5727d0952d955b09acde3789f6aae10f162743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>3H-ethylketocyclazocine</topic><topic>Analgesics</topic><topic>Animals</topic><topic>Appetite</topic><topic>Autoradiography</topic><topic>Binding, Competitive</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Corpus Striatum - metabolism</topic><topic>Cyclazocine - analogs & derivatives</topic><topic>Cyclazocine - metabolism</topic><topic>Drinking</topic><topic>Enkephalin, Leucine - analogs & derivatives</topic><topic>Enkephalin, Leucine - metabolism</topic><topic>Enkephalin, Leucine-2-Alanine</topic><topic>Ethylketocyclazocine</topic><topic>Feeding</topic><topic>Feeding Behavior - physiology</topic><topic>Film autoradiography</topic><topic>Gustatory neuroanatomy</topic><topic>Kappa opiate receptors</topic><topic>Limbic System - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Morphine - metabolism</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Receptors, Opioid - metabolism</topic><topic>Receptors, Opioid, kappa</topic><topic>Taste - physiology</topic><topic>Taste preference</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lynch, Wesley C.</creatorcontrib><creatorcontrib>Watt, John</creatorcontrib><creatorcontrib>Krall, Susan</creatorcontrib><creatorcontrib>Paden, Charles M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lynch, Wesley C.</au><au>Watt, John</au><au>Krall, Susan</au><au>Paden, Charles M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autoradiographic localization of kappa opiate receptors in CNS taste and feeding areas</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1985-05</date><risdate>1985</risdate><volume>22</volume><issue>5</issue><spage>699</spage><epage>705</epage><pages>699-705</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>Recent evidence suggests that kappa opiate receptors may play a key role in the regulation of appetite [21]. Such evidence implies that kappa receptors might be localized within specific brain areas known to regulate ingestive behaviors. On the basis of this implication we employed an
in vitro film autoradiographic technique using
3H-ethylketocyclazozine as ligand to identify putative kappa receptors [7] within CNS “taste” nuclei [23] and surrounding areas. Coronal cryostat sections of rat brain were incubated with ligand in the presence of D-Ala
2, D-Leu
5-enkephalin (DADLE) and morphine, apposed to LKB Ultrofilm for 60 days, processed and kappa receptor densities evaluated with the aid of a hand held photometer and video image analyzer. Highest kappa receptor densities were found within various gustatory and feeding sites including the rostral pole of the nucleus of the solitary tract, parabrachial nuclei, ventral posterior and medial portions of the thalamus, medial hypothalamus, medial nuclei of the amygdala and bed nucleus of the stria terminalis. Various other midline and medial limbic areas also showed significant kappa densities.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2989940</pmid><doi>10.1016/0091-3057(85)90516-7</doi><tpages>7</tpages></addata></record> |
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| subjects | 3H-ethylketocyclazocine Analgesics Animals Appetite Autoradiography Binding, Competitive Biological and medical sciences Brain - metabolism Corpus Striatum - metabolism Cyclazocine - analogs & derivatives Cyclazocine - metabolism Drinking Enkephalin, Leucine - analogs & derivatives Enkephalin, Leucine - metabolism Enkephalin, Leucine-2-Alanine Ethylketocyclazocine Feeding Feeding Behavior - physiology Film autoradiography Gustatory neuroanatomy Kappa opiate receptors Limbic System - metabolism Male Medical sciences Morphine - metabolism Neuropharmacology Pharmacology. Drug treatments Rats Receptors, Opioid - metabolism Receptors, Opioid, kappa Taste - physiology Taste preference |
| title | Autoradiographic localization of kappa opiate receptors in CNS taste and feeding areas |
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