Cerebrospinal fluid folate and cobalamin levels in febrile convulsion
Folate and cobalamin parameters were studied in the serum and cerebrospinal fluid of 40 febrile paediatric patients. Eighteen of these children were in a state of febrile convulsion while the remaining 22 were non-convulsing. The serum folate concentration of all the patients was higher than that of...
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| Veröffentlicht in: | Journal of the neurological sciences 1985-05, Vol.68 (2), p.185-190 |
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| creator | Osifo, Bola O.A. Lukanmbi, F.A. Familusi, J.B. |
| description | Folate and cobalamin parameters were studied in the serum and cerebrospinal fluid of 40 febrile paediatric patients. Eighteen of these children were in a state of febrile convulsion while the remaining 22 were non-convulsing. The serum folate concentration of all the patients was higher than that of the control group but the highest value was found in the convulsing children. There was no significant difference in the CSF folate levels between the two groups of patients.
The serum cobalamin levels of the patients were significantly lower than those of the control children and the lowest mean was observed in the convulsing state. On the other hand, there was no difference in the CSF cobalamin between the convulsing and non-convulsing children. These results confirm that there is an effective blood-brain barrier system for folate even when serum folate levels are higher than normal. There is also a definite decrease in serum cobalamin during pyrexia but this decrease is more apparent in the convulsing state. The role of cobalamin metabolism in convulsion is not clear. |
| doi_str_mv | 10.1016/0022-510X(85)90099-1 |
| format | Article |
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The serum cobalamin levels of the patients were significantly lower than those of the control children and the lowest mean was observed in the convulsing state. On the other hand, there was no difference in the CSF cobalamin between the convulsing and non-convulsing children. These results confirm that there is an effective blood-brain barrier system for folate even when serum folate levels are higher than normal. There is also a definite decrease in serum cobalamin during pyrexia but this decrease is more apparent in the convulsing state. The role of cobalamin metabolism in convulsion is not clear.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/0022-510X(85)90099-1</identifier><identifier>PMID: 4009203</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Biological and medical sciences ; Blood-Brain Barrier ; Cerebrospinal fluid ; Child, Preschool ; Cobalamin levels ; febrile convulsions ; Female ; Folate levels ; Folic Acid - blood ; Folic Acid - cerebrospinal fluid ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Infant ; Male ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Seizures, Febrile - blood ; Seizures, Febrile - cerebrospinal fluid ; Vitamin B 12 - blood ; Vitamin B 12 - cerebrospinal fluid</subject><ispartof>Journal of the neurological sciences, 1985-05, Vol.68 (2), p.185-190</ispartof><rights>1985</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-6f244e0c6400b0513266ff0766dda08a5dbb1b3a96e6226de66d516874188cbb3</citedby><cites>FETCH-LOGICAL-c386t-6f244e0c6400b0513266ff0766dda08a5dbb1b3a96e6226de66d516874188cbb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0022510X85900991$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9286889$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4009203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Osifo, Bola O.A.</creatorcontrib><creatorcontrib>Lukanmbi, F.A.</creatorcontrib><creatorcontrib>Familusi, J.B.</creatorcontrib><title>Cerebrospinal fluid folate and cobalamin levels in febrile convulsion</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>Folate and cobalamin parameters were studied in the serum and cerebrospinal fluid of 40 febrile paediatric patients. Eighteen of these children were in a state of febrile convulsion while the remaining 22 were non-convulsing. The serum folate concentration of all the patients was higher than that of the control group but the highest value was found in the convulsing children. There was no significant difference in the CSF folate levels between the two groups of patients.
The serum cobalamin levels of the patients were significantly lower than those of the control children and the lowest mean was observed in the convulsing state. On the other hand, there was no difference in the CSF cobalamin between the convulsing and non-convulsing children. These results confirm that there is an effective blood-brain barrier system for folate even when serum folate levels are higher than normal. There is also a definite decrease in serum cobalamin during pyrexia but this decrease is more apparent in the convulsing state. The role of cobalamin metabolism in convulsion is not clear.</description><subject>Biological and medical sciences</subject><subject>Blood-Brain Barrier</subject><subject>Cerebrospinal fluid</subject><subject>Child, Preschool</subject><subject>Cobalamin levels</subject><subject>febrile convulsions</subject><subject>Female</subject><subject>Folate levels</subject><subject>Folic Acid - blood</subject><subject>Folic Acid - cerebrospinal fluid</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Seizures, Febrile - blood</subject><subject>Seizures, Febrile - cerebrospinal fluid</subject><subject>Vitamin B 12 - blood</subject><subject>Vitamin B 12 - cerebrospinal fluid</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEURYMoWqv_QGEWIroYTTIzabIRpNQPKLhRcBfy8QKRdKYmnYL_3owdunSVwD335eUgdEHwHcGE3WNMadkQ_HnDm1uBsRAlOUATwme8bDivDtFkj5yg05S-MMaMc3GMjuuMU1xN0GIOEXTs0tq3KhQu9N4WrgtqA4VqbWE6rYJa-bYIsIWQinxzueAD5Kzd9iH5rj1DR06FBOfjOUUfT4v3-Uu5fHt-nT8uS1NxtimZo3UN2LD8vMYNqShjzuEZY9YqzFVjtSa6UoIBo5RZyEFDGJ_VhHOjdTVF17u569h995A2cuWTgRBUC12f5IwRToUQGax3oMlfSxGcXEe_UvFHEiwHe3JQIwc1kjfyz54kuXY5zu_1Cuy-NOrK-dWYq2RUcFG1xqc9Jigf_GbsYYdlYbD1EGUyHloD1kcwG2k7__8ev2y-iu0</recordid><startdate>198505</startdate><enddate>198505</enddate><creator>Osifo, Bola O.A.</creator><creator>Lukanmbi, F.A.</creator><creator>Familusi, J.B.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198505</creationdate><title>Cerebrospinal fluid folate and cobalamin levels in febrile convulsion</title><author>Osifo, Bola O.A. ; Lukanmbi, F.A. ; Familusi, J.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-6f244e0c6400b0513266ff0766dda08a5dbb1b3a96e6226de66d516874188cbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Biological and medical sciences</topic><topic>Blood-Brain Barrier</topic><topic>Cerebrospinal fluid</topic><topic>Child, Preschool</topic><topic>Cobalamin levels</topic><topic>febrile convulsions</topic><topic>Female</topic><topic>Folate levels</topic><topic>Folic Acid - blood</topic><topic>Folic Acid - cerebrospinal fluid</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Seizures, Febrile - blood</topic><topic>Seizures, Febrile - cerebrospinal fluid</topic><topic>Vitamin B 12 - blood</topic><topic>Vitamin B 12 - cerebrospinal fluid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Osifo, Bola O.A.</creatorcontrib><creatorcontrib>Lukanmbi, F.A.</creatorcontrib><creatorcontrib>Familusi, J.B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Osifo, Bola O.A.</au><au>Lukanmbi, F.A.</au><au>Familusi, J.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebrospinal fluid folate and cobalamin levels in febrile convulsion</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1985-05</date><risdate>1985</risdate><volume>68</volume><issue>2</issue><spage>185</spage><epage>190</epage><pages>185-190</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>Folate and cobalamin parameters were studied in the serum and cerebrospinal fluid of 40 febrile paediatric patients. Eighteen of these children were in a state of febrile convulsion while the remaining 22 were non-convulsing. The serum folate concentration of all the patients was higher than that of the control group but the highest value was found in the convulsing children. There was no significant difference in the CSF folate levels between the two groups of patients.
The serum cobalamin levels of the patients were significantly lower than those of the control children and the lowest mean was observed in the convulsing state. On the other hand, there was no difference in the CSF cobalamin between the convulsing and non-convulsing children. These results confirm that there is an effective blood-brain barrier system for folate even when serum folate levels are higher than normal. There is also a definite decrease in serum cobalamin during pyrexia but this decrease is more apparent in the convulsing state. The role of cobalamin metabolism in convulsion is not clear.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>4009203</pmid><doi>10.1016/0022-510X(85)90099-1</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of the neurological sciences, 1985-05, Vol.68 (2), p.185-190 |
| issn | 0022-510X 1878-5883 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Blood-Brain Barrier Cerebrospinal fluid Child, Preschool Cobalamin levels febrile convulsions Female Folate levels Folic Acid - blood Folic Acid - cerebrospinal fluid Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Infant Male Medical sciences Nervous system (semeiology, syndromes) Neurology Seizures, Febrile - blood Seizures, Febrile - cerebrospinal fluid Vitamin B 12 - blood Vitamin B 12 - cerebrospinal fluid |
| title | Cerebrospinal fluid folate and cobalamin levels in febrile convulsion |
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