Simultaneous Liquid Chromatographic Determination of Glutaric Acid, Phenylephrine, and Benzyl Alcohol in a Prototype Nasal Spray with Application to Di- and Tricarboxylic Acids
A rapid reversed-phase high-performance liquid chromatographic method for the simultaneous determination of glutaric acid, phenylephrine, and benzyl alcohol in nasal spray has been developed. UV detection was utilized at 210nm for the assay of glutaric acid and phenylephrine with an adjustment to 25...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1985-03, Vol.74 (3), p.312-315 |
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| container_title | Journal of pharmaceutical sciences |
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| creator | Wilson, T.D. Forde, M.D. Crain, A.V.R. |
| description | A rapid reversed-phase high-performance liquid chromatographic method for the simultaneous determination of glutaric acid, phenylephrine, and benzyl alcohol in nasal spray has been developed. UV detection was utilized at 210nm for the assay of glutaric acid and phenylephrine with an adjustment to 254nm for the measurement of benzyl alcohol. Linearity and recovery data were obtained for each component in spiked placebo studies. An investigation of the retention mechanisms of the three components showed that phenylephrine was retained by ion-pairing with octanesulfonate anion while glutaric acid and benzyl alcohol partitioned as a suppressed ion and a neutral molecule, respectively. The method has been further extended to the reversedphase separation of di- and tricarboxylic acids using a totally aqueous 0.0074M phosphoric acid mobile phase. The retention of these acids was related to their octanol–water partition coefficients and structural variation. |
| doi_str_mv | 10.1002/jps.2600740318 |
| format | Article |
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UV detection was utilized at 210nm for the assay of glutaric acid and phenylephrine with an adjustment to 254nm for the measurement of benzyl alcohol. Linearity and recovery data were obtained for each component in spiked placebo studies. An investigation of the retention mechanisms of the three components showed that phenylephrine was retained by ion-pairing with octanesulfonate anion while glutaric acid and benzyl alcohol partitioned as a suppressed ion and a neutral molecule, respectively. The method has been further extended to the reversedphase separation of di- and tricarboxylic acids using a totally aqueous 0.0074M phosphoric acid mobile phase. The retention of these acids was related to their octanol–water partition coefficients and structural variation.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600740318</identifier><identifier>PMID: 2989484</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Aerosols ; Alkanesulfonates ; Alkanesulfonic Acids ; Analysis ; Applied sciences ; Benzyl Alcohol ; Benzyl Alcohols - analysis ; Benzyl Compounds - analysis ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; Dicarboxylic Acids - analysis ; Exact sciences and technology ; General pharmacology ; Glutarates - analysis ; Indicators and Reagents ; Medical sciences ; Other techniques and industries ; Pharmacology. Drug treatments ; Phenylephrine - analysis ; Phosphoric Acids - analysis ; Spectrophotometry, Ultraviolet ; Tricarboxylic Acids - analysis</subject><ispartof>Journal of pharmaceutical sciences, 1985-03, Vol.74 (3), p.312-315</ispartof><rights>1985 Wiley‐Liss, Inc., A Wiley Company</rights><rights>Copyright © 1985 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4008-7d64fff87533be893027cca29c73d81bae1a2d2856735abe938f16beeb788823</citedby><cites>FETCH-LOGICAL-c4008-7d64fff87533be893027cca29c73d81bae1a2d2856735abe938f16beeb788823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600740318$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600740318$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8543350$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8836820$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2989484$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wilson, T.D.</creatorcontrib><creatorcontrib>Forde, M.D.</creatorcontrib><creatorcontrib>Crain, A.V.R.</creatorcontrib><title>Simultaneous Liquid Chromatographic Determination of Glutaric Acid, Phenylephrine, and Benzyl Alcohol in a Prototype Nasal Spray with Application to Di- and Tricarboxylic Acids</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>A rapid reversed-phase high-performance liquid chromatographic method for the simultaneous determination of glutaric acid, phenylephrine, and benzyl alcohol in nasal spray has been developed. UV detection was utilized at 210nm for the assay of glutaric acid and phenylephrine with an adjustment to 254nm for the measurement of benzyl alcohol. Linearity and recovery data were obtained for each component in spiked placebo studies. An investigation of the retention mechanisms of the three components showed that phenylephrine was retained by ion-pairing with octanesulfonate anion while glutaric acid and benzyl alcohol partitioned as a suppressed ion and a neutral molecule, respectively. The method has been further extended to the reversedphase separation of di- and tricarboxylic acids using a totally aqueous 0.0074M phosphoric acid mobile phase. The retention of these acids was related to their octanol–water partition coefficients and structural variation.</description><subject>Aerosols</subject><subject>Alkanesulfonates</subject><subject>Alkanesulfonic Acids</subject><subject>Analysis</subject><subject>Applied sciences</subject><subject>Benzyl Alcohol</subject><subject>Benzyl Alcohols - analysis</subject><subject>Benzyl Compounds - analysis</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Dicarboxylic Acids - analysis</subject><subject>Exact sciences and technology</subject><subject>General pharmacology</subject><subject>Glutarates - analysis</subject><subject>Indicators and Reagents</subject><subject>Medical sciences</subject><subject>Other techniques and industries</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenylephrine - analysis</subject><subject>Phosphoric Acids - analysis</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Tricarboxylic Acids - analysis</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-P0zAQxSMEWsrClRuSD4jTpjh2EjvHbhfKn6pUaiWOluNMiBc3ztoOu-FT8RHJkqqIA9rTHN7vvRnNi6KXCZ4nGJO3152fkxxjlmKa8EfRLMkIjnOcsMfRbARITLO0eBo98_4aY5zjLDuLzkjBi5Sns-jXTh96E2QLtvdorW96XaFl4-xBBvvNya7RCl1BAHfQrQzatsjWaGX6IN2oLJSuLtC2gXYw0DVOt3CBZFuhS2h_DgYtjLKNNUi3SKKts8GGoQO0kV4atOucHNCtDg1adJ3RasoPFl3p-E_KftwhXWnvBnNc5p9HT2ppPLw4zvNo__7dfvkhXn9ZfVwu1rFKMeYxq_K0rmvOMkpL4AXFhCklSaEYrXhSSkgkqQjPckYzWUJBeZ3kJUDJOOeEnkdvptjO2ZsefBAH7RUYM31KsDzhhFM2gvMJVM5676AWndMH6QaRYHHfkBgbEn8bGg2vjsl9eYDqhB8rGfXXR116JU3tZKu0P2Gc05wT_CCWpZRm91gxYbfawPDAbeLTdvfPpfHk1T7A3ckr3Xcxfo1l4utmJdZZuilY8VnsRp5PPIy9_NDghFcaWgWVdqCCqKz-31N-A4Vy2uU</recordid><startdate>198503</startdate><enddate>198503</enddate><creator>Wilson, T.D.</creator><creator>Forde, M.D.</creator><creator>Crain, A.V.R.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>American Pharmaceutical Association</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198503</creationdate><title>Simultaneous Liquid Chromatographic Determination of Glutaric Acid, Phenylephrine, and Benzyl Alcohol in a Prototype Nasal Spray with Application to Di- and Tricarboxylic Acids</title><author>Wilson, T.D. ; Forde, M.D. ; Crain, A.V.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4008-7d64fff87533be893027cca29c73d81bae1a2d2856735abe938f16beeb788823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Aerosols</topic><topic>Alkanesulfonates</topic><topic>Alkanesulfonic Acids</topic><topic>Analysis</topic><topic>Applied sciences</topic><topic>Benzyl Alcohol</topic><topic>Benzyl Alcohols - analysis</topic><topic>Benzyl Compounds - analysis</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Dicarboxylic Acids - analysis</topic><topic>Exact sciences and technology</topic><topic>General pharmacology</topic><topic>Glutarates - analysis</topic><topic>Indicators and Reagents</topic><topic>Medical sciences</topic><topic>Other techniques and industries</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenylephrine - analysis</topic><topic>Phosphoric Acids - analysis</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Tricarboxylic Acids - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilson, T.D.</creatorcontrib><creatorcontrib>Forde, M.D.</creatorcontrib><creatorcontrib>Crain, A.V.R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilson, T.D.</au><au>Forde, M.D.</au><au>Crain, A.V.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous Liquid Chromatographic Determination of Glutaric Acid, Phenylephrine, and Benzyl Alcohol in a Prototype Nasal Spray with Application to Di- and Tricarboxylic Acids</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1985-03</date><risdate>1985</risdate><volume>74</volume><issue>3</issue><spage>312</spage><epage>315</epage><pages>312-315</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>A rapid reversed-phase high-performance liquid chromatographic method for the simultaneous determination of glutaric acid, phenylephrine, and benzyl alcohol in nasal spray has been developed. UV detection was utilized at 210nm for the assay of glutaric acid and phenylephrine with an adjustment to 254nm for the measurement of benzyl alcohol. Linearity and recovery data were obtained for each component in spiked placebo studies. An investigation of the retention mechanisms of the three components showed that phenylephrine was retained by ion-pairing with octanesulfonate anion while glutaric acid and benzyl alcohol partitioned as a suppressed ion and a neutral molecule, respectively. The method has been further extended to the reversedphase separation of di- and tricarboxylic acids using a totally aqueous 0.0074M phosphoric acid mobile phase. The retention of these acids was related to their octanol–water partition coefficients and structural variation.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>2989484</pmid><doi>10.1002/jps.2600740318</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1985-03, Vol.74 (3), p.312-315 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Aerosols Alkanesulfonates Alkanesulfonic Acids Analysis Applied sciences Benzyl Alcohol Benzyl Alcohols - analysis Benzyl Compounds - analysis Biological and medical sciences Chromatography, High Pressure Liquid Dicarboxylic Acids - analysis Exact sciences and technology General pharmacology Glutarates - analysis Indicators and Reagents Medical sciences Other techniques and industries Pharmacology. Drug treatments Phenylephrine - analysis Phosphoric Acids - analysis Spectrophotometry, Ultraviolet Tricarboxylic Acids - analysis |
| title | Simultaneous Liquid Chromatographic Determination of Glutaric Acid, Phenylephrine, and Benzyl Alcohol in a Prototype Nasal Spray with Application to Di- and Tricarboxylic Acids |
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