Gallstones and Risk of Gallbladder Cancer
The relationship between gallstones and gallbladder cancer was investigated in a case-control study in 131 subjects with gallbladder cancer and 2,399 subjects without gallbladder cancer. Included in the study were male and female subjects from 3 racial groups: white, black, and Southwestern American...
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| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 1985-07, Vol.75 (1), p.77-80 |
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| container_title | JNCI : Journal of the National Cancer Institute |
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| creator | Lowenfels, Albert B. Lindström, Clas G. Conway, Michael J. Hastings, Paul R. |
| description | The relationship between gallstones and gallbladder cancer was investigated in a case-control study in 131 subjects with gallbladder cancer and 2,399 subjects without gallbladder cancer. Included in the study were male and female subjects from 3 racial groups: white, black, and Southwestern American Indian. For the non-Indian group there was a significant relationship between gallstones and gallbladder cancer, with an overall estimated relative risk (RR) of 4.4 (95% confidence interval, 2.6–7.3). For the Indian population the overall estimated RR was much higher: RR = 20.9; 95% confidence interval = 8.1–54. By the combination of the RR, the prevalence of gallstones, and the overall incidence of gallbladder cancer, the risk of gallbladder cancer was calculated in each population for subjects with untreated gallstones. In older subjects with gallstones the estimated 20-year cumulative risk for gallbladder cancer ranged from 0.13% in black males to 1.5% in Indian females. It was concluded that the risk of gallbladder cancer in untreated subjects with gallstones is heterogeneous, depending on race and sex as well as the period of exposure to gallstones. |
| doi_str_mv | 10.1093/jnci/75.1.77 |
| format | Article |
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Included in the study were male and female subjects from 3 racial groups: white, black, and Southwestern American Indian. For the non-Indian group there was a significant relationship between gallstones and gallbladder cancer, with an overall estimated relative risk (RR) of 4.4 (95% confidence interval, 2.6–7.3). For the Indian population the overall estimated RR was much higher: RR = 20.9; 95% confidence interval = 8.1–54. By the combination of the RR, the prevalence of gallstones, and the overall incidence of gallbladder cancer, the risk of gallbladder cancer was calculated in each population for subjects with untreated gallstones. In older subjects with gallstones the estimated 20-year cumulative risk for gallbladder cancer ranged from 0.13% in black males to 1.5% in Indian females. It was concluded that the risk of gallbladder cancer in untreated subjects with gallstones is heterogeneous, depending on race and sex as well as the period of exposure to gallstones.</description><identifier>ISSN: 0027-8874</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/75.1.77</identifier><identifier>PMID: 3859698</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Aged ; Arizona ; Biological and medical sciences ; Black or African American ; Black People ; Cholelithiasis - complications ; Cholelithiasis - epidemiology ; Cholelithiasis - surgery ; Female ; Gallbladder Neoplasms - epidemiology ; Gallbladder Neoplasms - etiology ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Indians, North American ; Liver. Biliary tract. Portal circulation. 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Included in the study were male and female subjects from 3 racial groups: white, black, and Southwestern American Indian. For the non-Indian group there was a significant relationship between gallstones and gallbladder cancer, with an overall estimated relative risk (RR) of 4.4 (95% confidence interval, 2.6–7.3). For the Indian population the overall estimated RR was much higher: RR = 20.9; 95% confidence interval = 8.1–54. By the combination of the RR, the prevalence of gallstones, and the overall incidence of gallbladder cancer, the risk of gallbladder cancer was calculated in each population for subjects with untreated gallstones. In older subjects with gallstones the estimated 20-year cumulative risk for gallbladder cancer ranged from 0.13% in black males to 1.5% in Indian females. It was concluded that the risk of gallbladder cancer in untreated subjects with gallstones is heterogeneous, depending on race and sex as well as the period of exposure to gallstones.</description><subject>Aged</subject><subject>Arizona</subject><subject>Biological and medical sciences</subject><subject>Black or African American</subject><subject>Black People</subject><subject>Cholelithiasis - complications</subject><subject>Cholelithiasis - epidemiology</subject><subject>Cholelithiasis - surgery</subject><subject>Female</subject><subject>Gallbladder Neoplasms - epidemiology</subject><subject>Gallbladder Neoplasms - etiology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Indians, North American</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Louisiana</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Racial Groups</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Sweden</subject><subject>Tumors</subject><subject>White People</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j81Lw0AUxBdRaq3evAo5iOAh7X5mN0etthUKimgVL8sm-xbSbpM2m4L-96Y09F0G3m-YYRC6JnhIcMpGyzIvRlIMyVDKE9QnPMExJVicoj7GVMZKSX6OLkJY4vZSynuox5RIk1T10f3UeB-aqoQQmdJG70VYRZWL9u_MG2uhjsamzKG-RGfO-ABXnQ7Q5-T5YzyL56_Tl_HDPC6oZE2cK0iYcFYCGGiFY-6ko4oQxhwG64h1KYHMGsk5JJhnhOfSCCxYnnGgbIDuDrmbutruIDR6XYQcvDclVLugZUIUFW3cAN10xl22Bqs3dbE29Z_utrX8tuMm5Ma7up1RhKNNcaJSvO-LD7YiNPB7xKZe6UQyKfTs-0d_LR7Z5OltoSX7B7O-a1s</recordid><startdate>198507</startdate><enddate>198507</enddate><creator>Lowenfels, Albert B.</creator><creator>Lindström, Clas G.</creator><creator>Conway, Michael J.</creator><creator>Hastings, Paul R.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198507</creationdate><title>Gallstones and Risk of Gallbladder Cancer</title><author>Lowenfels, Albert B. ; Lindström, Clas G. ; Conway, Michael J. ; Hastings, Paul R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i273t-c8e635fd7eeaefd7404f7f281133f0edf1df91ebda744e604b14c7a5053cb4e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Aged</topic><topic>Arizona</topic><topic>Biological and medical sciences</topic><topic>Black or African American</topic><topic>Black People</topic><topic>Cholelithiasis - complications</topic><topic>Cholelithiasis - epidemiology</topic><topic>Cholelithiasis - surgery</topic><topic>Female</topic><topic>Gallbladder Neoplasms - epidemiology</topic><topic>Gallbladder Neoplasms - etiology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Indians, North American</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Louisiana</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Racial Groups</topic><topic>Retrospective Studies</topic><topic>Risk</topic><topic>Sweden</topic><topic>Tumors</topic><topic>White People</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lowenfels, Albert B.</creatorcontrib><creatorcontrib>Lindström, Clas G.</creatorcontrib><creatorcontrib>Conway, Michael J.</creatorcontrib><creatorcontrib>Hastings, Paul R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lowenfels, Albert B.</au><au>Lindström, Clas G.</au><au>Conway, Michael J.</au><au>Hastings, Paul R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gallstones and Risk of Gallbladder Cancer</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>Journal of the National Cancer Institute</addtitle><date>1985-07</date><risdate>1985</risdate><volume>75</volume><issue>1</issue><spage>77</spage><epage>80</epage><pages>77-80</pages><issn>0027-8874</issn><eissn>1460-2105</eissn><abstract>The relationship between gallstones and gallbladder cancer was investigated in a case-control study in 131 subjects with gallbladder cancer and 2,399 subjects without gallbladder cancer. Included in the study were male and female subjects from 3 racial groups: white, black, and Southwestern American Indian. For the non-Indian group there was a significant relationship between gallstones and gallbladder cancer, with an overall estimated relative risk (RR) of 4.4 (95% confidence interval, 2.6–7.3). For the Indian population the overall estimated RR was much higher: RR = 20.9; 95% confidence interval = 8.1–54. By the combination of the RR, the prevalence of gallstones, and the overall incidence of gallbladder cancer, the risk of gallbladder cancer was calculated in each population for subjects with untreated gallstones. In older subjects with gallstones the estimated 20-year cumulative risk for gallbladder cancer ranged from 0.13% in black males to 1.5% in Indian females. It was concluded that the risk of gallbladder cancer in untreated subjects with gallstones is heterogeneous, depending on race and sex as well as the period of exposure to gallstones.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>3859698</pmid><doi>10.1093/jnci/75.1.77</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0027-8874 |
| ispartof | JNCI : Journal of the National Cancer Institute, 1985-07, Vol.75 (1), p.77-80 |
| issn | 0027-8874 1460-2105 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Aged Arizona Biological and medical sciences Black or African American Black People Cholelithiasis - complications Cholelithiasis - epidemiology Cholelithiasis - surgery Female Gallbladder Neoplasms - epidemiology Gallbladder Neoplasms - etiology Gastroenterology. Liver. Pancreas. Abdomen Humans Indians, North American Liver. Biliary tract. Portal circulation. Exocrine pancreas Louisiana Male Medical sciences Middle Aged Racial Groups Retrospective Studies Risk Sweden Tumors White People |
| title | Gallstones and Risk of Gallbladder Cancer |
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