Antiulcer agents. 1. Gastric antisecretory and cytoprotective properties of substituted imidazo[1,2-a]pyridines

A novel class of antiulcer agents, the substituted imidazo[1,2-a]pyridines, is described. The present compounds are not histamine (H2) receptor antagonists nor are they prostaglandin analogues, yet they exhibit both gastric antisecretory and cytoprotective properties. The mechanism of gastric antise...

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Veröffentlicht in:	Journal of medicinal chemistry 1985-07, Vol.28 (7), p.876-892
Hauptverfasser:	Kaminski, James J, Bristol, James A, Puchalski, Chester, Lovey, Raymond G, Elliott, Arthur J, Guzik, Henry, Solomon, Daniel M, Conn, David J, Domalski, Martin S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Ulcer Agents - pharmacology Biological Assay Chemical Phenomena Chemistry Dogs Gastric Mucosa - drug effects Gastric Mucosa - metabolism Histamine - pharmacology Imidazoles - chemical synthesis Imidazoles - pharmacology Ligation Male Pyloric Antrum - physiology Pyridines - chemical synthesis Pyridines - pharmacology Rats Structure-Activity Relationship
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