Neuroblastomas treated at the four major child oncologic clinics in Denmark 1943-1980: An evaluation of 180 cases
One hundred and eighty cases of neuro‐blastomas from the four child oncology clinics are reviewed. The overall cure rate was 24%. During the 38‐year period, there was a significant increase in survival from 0% during the period of 1943–1950 to 32% during the period of 1971–1980. This improved surviv...
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| Veröffentlicht in: | Medical and pediatric oncology 1985, Vol.13 (4), p.180-186 |
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| container_title | Medical and pediatric oncology |
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| creator | Carlsen, Niels L. T. Schroeder, Henrik Bro, Poul V. Erichsen, Gunna Hamborg-Pedersen, Bente Jensen, Kaj Bjoern Nielsen, Ole H. |
| description | One hundred and eighty cases of neuro‐blastomas from the four child oncology clinics are reviewed. The overall cure rate was 24%. During the 38‐year period, there was a significant increase in survival from 0% during the period of 1943–1950 to 32% during the period of 1971–1980. This improved survival rate is most likely a result of adjuvant chemotherapy. Forty percent of the patients appear chronically ill, which reflects the fact that nearly 60% have metastases when they are first seen. In localized disease (stages I–II), the prognosis was favourable (cure rate 69%), while the prognosis for disseminated disease (stage III–IV) was poor (cure rate 5%). A favourable outcome was seen in patients under 1 year (survival rate 46%), and in patients with primary tumours located in the neck or mediastinum (survival rate 48%). When related to stage, however, the survival rates for the former tumours were not significantly better in patients below 1 year or in patients with cervical or thoracic tumours. As is the case in other studies, we found that survival is significantly poorer in males. |
| doi_str_mv | 10.1002/mpo.2950130404 |
| format | Article |
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T. ; Schroeder, Henrik ; Bro, Poul V. ; Erichsen, Gunna ; Hamborg-Pedersen, Bente ; Jensen, Kaj Bjoern ; Nielsen, Ole H.</creator><creatorcontrib>Carlsen, Niels L. T. ; Schroeder, Henrik ; Bro, Poul V. ; Erichsen, Gunna ; Hamborg-Pedersen, Bente ; Jensen, Kaj Bjoern ; Nielsen, Ole H.</creatorcontrib><description>One hundred and eighty cases of neuro‐blastomas from the four child oncology clinics are reviewed. The overall cure rate was 24%. During the 38‐year period, there was a significant increase in survival from 0% during the period of 1943–1950 to 32% during the period of 1971–1980. This improved survival rate is most likely a result of adjuvant chemotherapy. Forty percent of the patients appear chronically ill, which reflects the fact that nearly 60% have metastases when they are first seen. In localized disease (stages I–II), the prognosis was favourable (cure rate 69%), while the prognosis for disseminated disease (stage III–IV) was poor (cure rate 5%). A favourable outcome was seen in patients under 1 year (survival rate 46%), and in patients with primary tumours located in the neck or mediastinum (survival rate 48%). When related to stage, however, the survival rates for the former tumours were not significantly better in patients below 1 year or in patients with cervical or thoracic tumours. As is the case in other studies, we found that survival is significantly poorer in males.</description><identifier>ISSN: 0098-1532</identifier><identifier>EISSN: 1096-911X</identifier><identifier>DOI: 10.1002/mpo.2950130404</identifier><identifier>PMID: 4010620</identifier><identifier>CODEN: MPONDB</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Abdominal Neoplasms - drug therapy ; Adrenal Gland Neoplasms - drug therapy ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; beneficial effects from chemotherapy ; Biological and medical sciences ; Child, Preschool ; Combined Modality Therapy ; Head and Neck Neoplasms - drug therapy ; Humans ; Infant ; Medical sciences ; Neoplasm Staging ; neuroblastoma ; Neuroblastoma - diagnosis ; Neuroblastoma - drug therapy ; Neuroblastoma - pathology ; Neurology ; Prognosis ; prognostic factors ; Radiotherapy Dosage ; Thoracic Neoplasms - drug therapy ; Tumors of the nervous system. Phacomatoses ; Vanilmandelic Acid - urine</subject><ispartof>Medical and pediatric oncology, 1985, Vol.13 (4), p.180-186</ispartof><rights>Copyright © 1985 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1985 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3224-acb9ff896e7365b67d63bb718b30328b3892eb48676c0a7a1e857c307d7973cf3</citedby><cites>FETCH-LOGICAL-c3224-acb9ff896e7365b67d63bb718b30328b3892eb48676c0a7a1e857c307d7973cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmpo.2950130404$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmpo.2950130404$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9292343$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4010620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carlsen, Niels L. T.</creatorcontrib><creatorcontrib>Schroeder, Henrik</creatorcontrib><creatorcontrib>Bro, Poul V.</creatorcontrib><creatorcontrib>Erichsen, Gunna</creatorcontrib><creatorcontrib>Hamborg-Pedersen, Bente</creatorcontrib><creatorcontrib>Jensen, Kaj Bjoern</creatorcontrib><creatorcontrib>Nielsen, Ole H.</creatorcontrib><title>Neuroblastomas treated at the four major child oncologic clinics in Denmark 1943-1980: An evaluation of 180 cases</title><title>Medical and pediatric oncology</title><addtitle>Med. Pediatr. Oncol</addtitle><description>One hundred and eighty cases of neuro‐blastomas from the four child oncology clinics are reviewed. The overall cure rate was 24%. During the 38‐year period, there was a significant increase in survival from 0% during the period of 1943–1950 to 32% during the period of 1971–1980. This improved survival rate is most likely a result of adjuvant chemotherapy. Forty percent of the patients appear chronically ill, which reflects the fact that nearly 60% have metastases when they are first seen. In localized disease (stages I–II), the prognosis was favourable (cure rate 69%), while the prognosis for disseminated disease (stage III–IV) was poor (cure rate 5%). A favourable outcome was seen in patients under 1 year (survival rate 46%), and in patients with primary tumours located in the neck or mediastinum (survival rate 48%). When related to stage, however, the survival rates for the former tumours were not significantly better in patients below 1 year or in patients with cervical or thoracic tumours. As is the case in other studies, we found that survival is significantly poorer in males.</description><subject>Abdominal Neoplasms - drug therapy</subject><subject>Adrenal Gland Neoplasms - drug therapy</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>beneficial effects from chemotherapy</subject><subject>Biological and medical sciences</subject><subject>Child, Preschool</subject><subject>Combined Modality Therapy</subject><subject>Head and Neck Neoplasms - drug therapy</subject><subject>Humans</subject><subject>Infant</subject><subject>Medical sciences</subject><subject>Neoplasm Staging</subject><subject>neuroblastoma</subject><subject>Neuroblastoma - diagnosis</subject><subject>Neuroblastoma - drug therapy</subject><subject>Neuroblastoma - pathology</subject><subject>Neurology</subject><subject>Prognosis</subject><subject>prognostic factors</subject><subject>Radiotherapy Dosage</subject><subject>Thoracic Neoplasms - drug therapy</subject><subject>Tumors of the nervous system. Phacomatoses</subject><subject>Vanilmandelic Acid - urine</subject><issn>0098-1532</issn><issn>1096-911X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1vFCEYxonR1LV69WbCwXib9QVm-PDWtLY13bZ70OiNMAxjqcywhZlq_3tpdrPGUy8Q8vye9-MBobcElgSAfhw2cUlVA4RBDfUztCCgeKUI-fEcLQCUrEjD6Ev0KudbKG8l5AE6qIEAp7BAd1duTrENJk9xMBlPyZnJddhMeLpxuI9zwoO5jQnbGx86HEcbQ_zpLbbBj95m7Ed84sbBpF-YqJpVREn4hI9G7O5NmM3k44hjj4kEbE12-TV60ZuQ3ZvdfYi-nX7-enxera7PvhwfrSrLKK0rY1vV91JxJxhvWi46ztpWENkyYLScUlHX1pILbsEIQ5xshGUgOqEEsz07RB-2dTcp3s0uT3rw2boQzOjinLXgZSRoRAGXW9CmmHNyvd4kX_Z50AT0Y8a6ZKz_ZVwM73aV53Zw3R7fhVr09zvdZGtCn8xofd5jiirKalYwtcV---AenmiqL9fX_41Qbb0-T-7P3ls-QXPBRKO_X53p9cVKrtfyQkv2Fyq4ohQ</recordid><startdate>1985</startdate><enddate>1985</enddate><creator>Carlsen, Niels L. T.</creator><creator>Schroeder, Henrik</creator><creator>Bro, Poul V.</creator><creator>Erichsen, Gunna</creator><creator>Hamborg-Pedersen, Bente</creator><creator>Jensen, Kaj Bjoern</creator><creator>Nielsen, Ole H.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1985</creationdate><title>Neuroblastomas treated at the four major child oncologic clinics in Denmark 1943-1980: An evaluation of 180 cases</title><author>Carlsen, Niels L. T. ; Schroeder, Henrik ; Bro, Poul V. ; Erichsen, Gunna ; Hamborg-Pedersen, Bente ; Jensen, Kaj Bjoern ; Nielsen, Ole H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3224-acb9ff896e7365b67d63bb718b30328b3892eb48676c0a7a1e857c307d7973cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Abdominal Neoplasms - drug therapy</topic><topic>Adrenal Gland Neoplasms - drug therapy</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>beneficial effects from chemotherapy</topic><topic>Biological and medical sciences</topic><topic>Child, Preschool</topic><topic>Combined Modality Therapy</topic><topic>Head and Neck Neoplasms - drug therapy</topic><topic>Humans</topic><topic>Infant</topic><topic>Medical sciences</topic><topic>Neoplasm Staging</topic><topic>neuroblastoma</topic><topic>Neuroblastoma - diagnosis</topic><topic>Neuroblastoma - drug therapy</topic><topic>Neuroblastoma - pathology</topic><topic>Neurology</topic><topic>Prognosis</topic><topic>prognostic factors</topic><topic>Radiotherapy Dosage</topic><topic>Thoracic Neoplasms - drug therapy</topic><topic>Tumors of the nervous system. Phacomatoses</topic><topic>Vanilmandelic Acid - urine</topic><toplevel>online_resources</toplevel><creatorcontrib>Carlsen, Niels L. T.</creatorcontrib><creatorcontrib>Schroeder, Henrik</creatorcontrib><creatorcontrib>Bro, Poul V.</creatorcontrib><creatorcontrib>Erichsen, Gunna</creatorcontrib><creatorcontrib>Hamborg-Pedersen, Bente</creatorcontrib><creatorcontrib>Jensen, Kaj Bjoern</creatorcontrib><creatorcontrib>Nielsen, Ole H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medical and pediatric oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carlsen, Niels L. T.</au><au>Schroeder, Henrik</au><au>Bro, Poul V.</au><au>Erichsen, Gunna</au><au>Hamborg-Pedersen, Bente</au><au>Jensen, Kaj Bjoern</au><au>Nielsen, Ole H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroblastomas treated at the four major child oncologic clinics in Denmark 1943-1980: An evaluation of 180 cases</atitle><jtitle>Medical and pediatric oncology</jtitle><addtitle>Med. Pediatr. Oncol</addtitle><date>1985</date><risdate>1985</risdate><volume>13</volume><issue>4</issue><spage>180</spage><epage>186</epage><pages>180-186</pages><issn>0098-1532</issn><eissn>1096-911X</eissn><coden>MPONDB</coden><abstract>One hundred and eighty cases of neuro‐blastomas from the four child oncology clinics are reviewed. The overall cure rate was 24%. During the 38‐year period, there was a significant increase in survival from 0% during the period of 1943–1950 to 32% during the period of 1971–1980. This improved survival rate is most likely a result of adjuvant chemotherapy. Forty percent of the patients appear chronically ill, which reflects the fact that nearly 60% have metastases when they are first seen. In localized disease (stages I–II), the prognosis was favourable (cure rate 69%), while the prognosis for disseminated disease (stage III–IV) was poor (cure rate 5%). A favourable outcome was seen in patients under 1 year (survival rate 46%), and in patients with primary tumours located in the neck or mediastinum (survival rate 48%). When related to stage, however, the survival rates for the former tumours were not significantly better in patients below 1 year or in patients with cervical or thoracic tumours. As is the case in other studies, we found that survival is significantly poorer in males.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>4010620</pmid><doi>10.1002/mpo.2950130404</doi><tpages>7</tpages></addata></record> |
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| ispartof | Medical and pediatric oncology, 1985, Vol.13 (4), p.180-186 |
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| subjects | Abdominal Neoplasms - drug therapy Adrenal Gland Neoplasms - drug therapy Antineoplastic Combined Chemotherapy Protocols - therapeutic use beneficial effects from chemotherapy Biological and medical sciences Child, Preschool Combined Modality Therapy Head and Neck Neoplasms - drug therapy Humans Infant Medical sciences Neoplasm Staging neuroblastoma Neuroblastoma - diagnosis Neuroblastoma - drug therapy Neuroblastoma - pathology Neurology Prognosis prognostic factors Radiotherapy Dosage Thoracic Neoplasms - drug therapy Tumors of the nervous system. Phacomatoses Vanilmandelic Acid - urine |
| title | Neuroblastomas treated at the four major child oncologic clinics in Denmark 1943-1980: An evaluation of 180 cases |
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