Mechanisms of angina pectoris in syndrome X assessed by myocardial perfusion dynamics and heart rate variability
The fundamental abnormality in syndrome X (angina pectoris, ischaemia-like stress ECG despite angiographically normal coronary arteries) might be patchily distributed increased tone in pre-arteriolar coronary vessels with compensatory release of adenosine. The aim of this study was to confirm this h...
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| Veröffentlicht in: | European heart journal 1995-11, Vol.16 (11), p.1571-1577 |
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| creator | MEEDER, J. G. BLANKSMA, P. K. CRIJNS, H. J. G. M. ANTHONIO, R. L. PRUIM, J. BROUWER, J. DE JONG, R. M. VAN DER WALL, E. E. VAALBURG, W. LIE, K. I. |
| description | The fundamental abnormality in syndrome X (angina pectoris, ischaemia-like stress ECG despite angiographically normal coronary arteries) might be patchily distributed increased tone in pre-arteriolar coronary vessels with compensatory release of adenosine. The aim of this study was to confirm this hypothesis and to explore its relationships with autonomic system functioning. Using parametric positron emission tomography, myocardial perfusion was examined in 480 segments in 16 syndrome X patients and 16 age- and sex-matched healthy volunteers. Autonomic function was explored by Holier monitoring of time domain parameters of heart rate variability. Compared to volunteers, both mean perfusion (123 ± 55 vs 87±16mg. min−1. 100g−1; P |
| doi_str_mv | 10.1093/oxfordjournals.eurheartj.a060780 |
| format | Article |
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G. ; BLANKSMA, P. K. ; CRIJNS, H. J. G. M. ; ANTHONIO, R. L. ; PRUIM, J. ; BROUWER, J. ; DE JONG, R. M. ; VAN DER WALL, E. E. ; VAALBURG, W. ; LIE, K. I.</creator><creatorcontrib>MEEDER, J. G. ; BLANKSMA, P. K. ; CRIJNS, H. J. G. M. ; ANTHONIO, R. L. ; PRUIM, J. ; BROUWER, J. ; DE JONG, R. M. ; VAN DER WALL, E. E. ; VAALBURG, W. ; LIE, K. I.</creatorcontrib><description>The fundamental abnormality in syndrome X (angina pectoris, ischaemia-like stress ECG despite angiographically normal coronary arteries) might be patchily distributed increased tone in pre-arteriolar coronary vessels with compensatory release of adenosine. The aim of this study was to confirm this hypothesis and to explore its relationships with autonomic system functioning. Using parametric positron emission tomography, myocardial perfusion was examined in 480 segments in 16 syndrome X patients and 16 age- and sex-matched healthy volunteers. Autonomic function was explored by Holier monitoring of time domain parameters of heart rate variability. Compared to volunteers, both mean perfusion (123 ± 55 vs 87±16mg. min−1. 100g−1; P<0.01) and its coefficient of variation (17.0±3.2 vs 13.6±2.2%; P<0.01) as a measure of perfusion heterogeneity, were higher in patients with syndrome X. In contrast to the findings in the control subjects, patients showed an inverse relationship between perfusion heterogeneity (coefficient of variation of segmental perfusion) and autonomic tone (heart rate variability parameters). Since marked perfusion heterogeneity (inversely related to autonomic tone) and higher overall perfusion were found, the study supports the data that in syndrome X hyperreactivity of small coronary vessels with compensatory release of adenosine may be patchily distributed.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/oxfordjournals.eurheartj.a060780</identifier><identifier>PMID: 8881850</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Angina Pectoris - diagnostic imaging ; Angina Pectoris - physiopathology ; angina pectoris and normal coronary angiograms ; autonomic function ; Biological and medical sciences ; Cardiology. Vascular system ; Coronary Circulation ; Coronary heart disease ; Electrocardiography, Ambulatory ; Heart ; Heart Rate ; Hemodynamics ; Humans ; Medical sciences ; Microvascular Angina - diagnostic imaging ; Microvascular Angina - physiopathology ; Middle Aged ; positron emission tomography ; Syndrome X ; Tomography, Emission-Computed</subject><ispartof>European heart journal, 1995-11, Vol.16 (11), p.1571-1577</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-e467100f1c83c725c0c3367ad5bb1a1e37f39a50422f11d1d2b9d99bc6d0644b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2970139$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8881850$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MEEDER, J. G.</creatorcontrib><creatorcontrib>BLANKSMA, P. K.</creatorcontrib><creatorcontrib>CRIJNS, H. J. G. M.</creatorcontrib><creatorcontrib>ANTHONIO, R. L.</creatorcontrib><creatorcontrib>PRUIM, J.</creatorcontrib><creatorcontrib>BROUWER, J.</creatorcontrib><creatorcontrib>DE JONG, R. M.</creatorcontrib><creatorcontrib>VAN DER WALL, E. E.</creatorcontrib><creatorcontrib>VAALBURG, W.</creatorcontrib><creatorcontrib>LIE, K. I.</creatorcontrib><title>Mechanisms of angina pectoris in syndrome X assessed by myocardial perfusion dynamics and heart rate variability</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>The fundamental abnormality in syndrome X (angina pectoris, ischaemia-like stress ECG despite angiographically normal coronary arteries) might be patchily distributed increased tone in pre-arteriolar coronary vessels with compensatory release of adenosine. The aim of this study was to confirm this hypothesis and to explore its relationships with autonomic system functioning. Using parametric positron emission tomography, myocardial perfusion was examined in 480 segments in 16 syndrome X patients and 16 age- and sex-matched healthy volunteers. Autonomic function was explored by Holier monitoring of time domain parameters of heart rate variability. Compared to volunteers, both mean perfusion (123 ± 55 vs 87±16mg. min−1. 100g−1; P<0.01) and its coefficient of variation (17.0±3.2 vs 13.6±2.2%; P<0.01) as a measure of perfusion heterogeneity, were higher in patients with syndrome X. In contrast to the findings in the control subjects, patients showed an inverse relationship between perfusion heterogeneity (coefficient of variation of segmental perfusion) and autonomic tone (heart rate variability parameters). Since marked perfusion heterogeneity (inversely related to autonomic tone) and higher overall perfusion were found, the study supports the data that in syndrome X hyperreactivity of small coronary vessels with compensatory release of adenosine may be patchily distributed.</description><subject>Adult</subject><subject>Angina Pectoris - diagnostic imaging</subject><subject>Angina Pectoris - physiopathology</subject><subject>angina pectoris and normal coronary angiograms</subject><subject>autonomic function</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Circulation</subject><subject>Coronary heart disease</subject><subject>Electrocardiography, Ambulatory</subject><subject>Heart</subject><subject>Heart Rate</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Microvascular Angina - diagnostic imaging</subject><subject>Microvascular Angina - physiopathology</subject><subject>Middle Aged</subject><subject>positron emission tomography</subject><subject>Syndrome X</subject><subject>Tomography, Emission-Computed</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkF2L1DAUhoMo6zj6E4RciHjT2aRpkuZOGXRX2EV2_WDwJpwmqZuxTWaTVrb_3rpTBoQDuXgf3nPyIPSOkg0lip3HhzYmu49jCtDljRvTnYM07DdABJE1eYJWlJdloUTFn6IVoYoXQtS75-hFzntCSC2oOENndV3TmpMVOlw7cwfB5z7j2GIIv3wAfHBmiMln7APOU7Ap9g7vMOTs5rG4mXA_RQPJeuhmOrVj9jFgOwXovclzj8WPl-EEg8N_IHlofOeH6SV61s6nu1fLu0bfP338tr0srr5cfN5-uCoMU2woXCUkJaSlpmZGltwQw5iQYHnTUKCOyZYp4KQqy5ZSS23ZKKtUY4QloqoatkZvj72HFO9Hlwfd-2xc10FwccxaCioVr-kMvj-CJsWck2v1Ifke0qQp0f-k6_-l65N0vUifK14vu8amd_ZUsFie8zdLDtlA1yYIxucTVipJ6PzrNSqOmM-DezjFkH5rIZnk-nL3U0t-ffH15vaH3rK_3fql3g</recordid><startdate>19951101</startdate><enddate>19951101</enddate><creator>MEEDER, J. G.</creator><creator>BLANKSMA, P. K.</creator><creator>CRIJNS, H. J. G. M.</creator><creator>ANTHONIO, R. L.</creator><creator>PRUIM, J.</creator><creator>BROUWER, J.</creator><creator>DE JONG, R. M.</creator><creator>VAN DER WALL, E. E.</creator><creator>VAALBURG, W.</creator><creator>LIE, K. I.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19951101</creationdate><title>Mechanisms of angina pectoris in syndrome X assessed by myocardial perfusion dynamics and heart rate variability</title><author>MEEDER, J. G. ; BLANKSMA, P. K. ; CRIJNS, H. J. G. M. ; ANTHONIO, R. L. ; PRUIM, J. ; BROUWER, J. ; DE JONG, R. M. ; VAN DER WALL, E. E. ; VAALBURG, W. ; LIE, K. I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-e467100f1c83c725c0c3367ad5bb1a1e37f39a50422f11d1d2b9d99bc6d0644b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Angina Pectoris - diagnostic imaging</topic><topic>Angina Pectoris - physiopathology</topic><topic>angina pectoris and normal coronary angiograms</topic><topic>autonomic function</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Circulation</topic><topic>Coronary heart disease</topic><topic>Electrocardiography, Ambulatory</topic><topic>Heart</topic><topic>Heart Rate</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Microvascular Angina - diagnostic imaging</topic><topic>Microvascular Angina - physiopathology</topic><topic>Middle Aged</topic><topic>positron emission tomography</topic><topic>Syndrome X</topic><topic>Tomography, Emission-Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MEEDER, J. G.</creatorcontrib><creatorcontrib>BLANKSMA, P. K.</creatorcontrib><creatorcontrib>CRIJNS, H. J. G. M.</creatorcontrib><creatorcontrib>ANTHONIO, R. L.</creatorcontrib><creatorcontrib>PRUIM, J.</creatorcontrib><creatorcontrib>BROUWER, J.</creatorcontrib><creatorcontrib>DE JONG, R. M.</creatorcontrib><creatorcontrib>VAN DER WALL, E. E.</creatorcontrib><creatorcontrib>VAALBURG, W.</creatorcontrib><creatorcontrib>LIE, K. I.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MEEDER, J. G.</au><au>BLANKSMA, P. K.</au><au>CRIJNS, H. J. G. M.</au><au>ANTHONIO, R. L.</au><au>PRUIM, J.</au><au>BROUWER, J.</au><au>DE JONG, R. M.</au><au>VAN DER WALL, E. E.</au><au>VAALBURG, W.</au><au>LIE, K. I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanisms of angina pectoris in syndrome X assessed by myocardial perfusion dynamics and heart rate variability</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>1995-11-01</date><risdate>1995</risdate><volume>16</volume><issue>11</issue><spage>1571</spage><epage>1577</epage><pages>1571-1577</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>The fundamental abnormality in syndrome X (angina pectoris, ischaemia-like stress ECG despite angiographically normal coronary arteries) might be patchily distributed increased tone in pre-arteriolar coronary vessels with compensatory release of adenosine. The aim of this study was to confirm this hypothesis and to explore its relationships with autonomic system functioning. Using parametric positron emission tomography, myocardial perfusion was examined in 480 segments in 16 syndrome X patients and 16 age- and sex-matched healthy volunteers. Autonomic function was explored by Holier monitoring of time domain parameters of heart rate variability. Compared to volunteers, both mean perfusion (123 ± 55 vs 87±16mg. min−1. 100g−1; P<0.01) and its coefficient of variation (17.0±3.2 vs 13.6±2.2%; P<0.01) as a measure of perfusion heterogeneity, were higher in patients with syndrome X. In contrast to the findings in the control subjects, patients showed an inverse relationship between perfusion heterogeneity (coefficient of variation of segmental perfusion) and autonomic tone (heart rate variability parameters). Since marked perfusion heterogeneity (inversely related to autonomic tone) and higher overall perfusion were found, the study supports the data that in syndrome X hyperreactivity of small coronary vessels with compensatory release of adenosine may be patchily distributed.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>8881850</pmid><doi>10.1093/oxfordjournals.eurheartj.a060780</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Angina Pectoris - diagnostic imaging Angina Pectoris - physiopathology angina pectoris and normal coronary angiograms autonomic function Biological and medical sciences Cardiology. Vascular system Coronary Circulation Coronary heart disease Electrocardiography, Ambulatory Heart Heart Rate Hemodynamics Humans Medical sciences Microvascular Angina - diagnostic imaging Microvascular Angina - physiopathology Middle Aged positron emission tomography Syndrome X Tomography, Emission-Computed |
| title | Mechanisms of angina pectoris in syndrome X assessed by myocardial perfusion dynamics and heart rate variability |
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