Assessment of glomerular filtration rate and effective renal plasma flow in cystic fibrosis
A study was conducted to examine renal function in 10 healthy control subjects and eight patients with cystic fibrosis in stable condition. Sequential bolus injections of 99mTc-DTPA and 125I-OIH were administered to assess glomerular filtration rate and effective renal plasma flow, respectively. Blo...
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| Veröffentlicht in: | J. Pediatr.; (United States) 1985-07, Vol.107 (1), p.64-70 |
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| container_title | J. Pediatr.; (United States) |
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| creator | Spino, Michael Chai, Roger P. Isles, Alan F. Balfe, J. Williamson Brown, Robert G. Thiessen, Jake J. MacLeod, Stuart M. |
| description | A study was conducted to examine renal function in 10 healthy control subjects and eight patients with cystic fibrosis in stable condition. Sequential bolus injections of 99mTc-DTPA and 125I-OIH were administered to assess glomerular filtration rate and effective renal plasma flow, respectively. Blood was subsequently collected for 3 hours, and urine for 24 hours. Renal clearances of both radioisotope markers were virtually identical in patients and controls. Inasmuch as neither glomerular filtration rate nor effective renal plasma flow was enhanced in patients with cystic fibrosis, increased clearance of drugs in these patients is unlikely to be the result of enhanced glomerular filtration or tubular secretion. |
| doi_str_mv | 10.1016/S0022-3476(85)80616-8 |
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Williamson ; Brown, Robert G. ; Thiessen, Jake J. ; MacLeod, Stuart M.</creator><creatorcontrib>Spino, Michael ; Chai, Roger P. ; Isles, Alan F. ; Balfe, J. Williamson ; Brown, Robert G. ; Thiessen, Jake J. ; MacLeod, Stuart M. ; Univ. of Toronto, Ontario, Canada</creatorcontrib><description>A study was conducted to examine renal function in 10 healthy control subjects and eight patients with cystic fibrosis in stable condition. Sequential bolus injections of 99mTc-DTPA and 125I-OIH were administered to assess glomerular filtration rate and effective renal plasma flow, respectively. Blood was subsequently collected for 3 hours, and urine for 24 hours. Renal clearances of both radioisotope markers were virtually identical in patients and controls. Inasmuch as neither glomerular filtration rate nor effective renal plasma flow was enhanced in patients with cystic fibrosis, increased clearance of drugs in these patients is unlikely to be the result of enhanced glomerular filtration or tubular secretion.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(85)80616-8</identifier><identifier>PMID: 3891948</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>550901 - Pathology- Tracer Techniques ; Adolescent ; Adult ; AMINO ACIDS ; BASIC BIOLOGICAL SCIENCES ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; Biological and medical sciences ; BIOLOGICAL MATERIALS ; BIOLOGICAL WASTES ; BLOOD FLOW ; BODY ; BODY FLUIDS ; CARBOXYLIC ACIDS ; CHELATING AGENTS ; CLEARANCE ; Cystic Fibrosis - diagnostic imaging ; Cystic Fibrosis - physiopathology ; DAYS LIVING RADIOISOTOPES ; DISEASES ; DRUGS ; DTPA ; DYNAMIC FUNCTION STUDIES ; ELECTRON CAPTURE RADIOISOTOPES ; EXCRETION ; Gastroenterology. Liver. Pancreas. Abdomen ; Glomerular Filtration Rate ; HEREDITARY DISEASES ; HOURS LIVING RADIOISOTOPES ; Humans ; INTERMEDIATE MASS NUCLEI ; IODINE 125 ; IODINE ISOTOPES ; Iodine Radioisotopes ; Iodohippuric Acid - blood ; ISOMERIC NUCLEI ; ISOMERIC TRANSITION ISOTOPES ; ISOTOPE APPLICATIONS ; ISOTOPES ; Kidney - diagnostic imaging ; Kidney - physiopathology ; Kidney Tubules - physiopathology ; KIDNEYS ; LABELLED COMPOUNDS ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; MATERIALS ; Mathematics ; Medical sciences ; Metabolic Clearance Rate ; NUCLEI ; ODD-EVEN NUCLEI ; ORGANIC ACIDS ; ORGANIC COMPOUNDS ; ORGANS ; Other diseases. Semiology ; PATIENTS ; Pentetic Acid - blood ; RADIOISOTOPES ; Radionuclide Imaging ; RADIOPROTECTIVE SUBSTANCES ; Regional Blood Flow ; RENAL CLEARANCE ; Technetium - blood ; TECHNETIUM 99 ; TECHNETIUM ISOTOPES ; Technetium Tc 99m Pentetate ; TRACER TECHNIQUES ; URINE ; WASTES ; YEARS LIVING RADIOISOTOPES</subject><ispartof>J. Pediatr.; (United States), 1985-07, Vol.107 (1), p.64-70</ispartof><rights>1985 The C. V. Mosby Company</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-b8c3237cb66b226633025ffb31c2ff028bed8df5e9eadadb5d3a087ce08584713</citedby><cites>FETCH-LOGICAL-c416t-b8c3237cb66b226633025ffb31c2ff028bed8df5e9eadadb5d3a087ce08584713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-3476(85)80616-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8452179$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3891948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5218389$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Spino, Michael</creatorcontrib><creatorcontrib>Chai, Roger P.</creatorcontrib><creatorcontrib>Isles, Alan F.</creatorcontrib><creatorcontrib>Balfe, J. Williamson</creatorcontrib><creatorcontrib>Brown, Robert G.</creatorcontrib><creatorcontrib>Thiessen, Jake J.</creatorcontrib><creatorcontrib>MacLeod, Stuart M.</creatorcontrib><creatorcontrib>Univ. of Toronto, Ontario, Canada</creatorcontrib><title>Assessment of glomerular filtration rate and effective renal plasma flow in cystic fibrosis</title><title>J. Pediatr.; (United States)</title><addtitle>J Pediatr</addtitle><description>A study was conducted to examine renal function in 10 healthy control subjects and eight patients with cystic fibrosis in stable condition. Sequential bolus injections of 99mTc-DTPA and 125I-OIH were administered to assess glomerular filtration rate and effective renal plasma flow, respectively. Blood was subsequently collected for 3 hours, and urine for 24 hours. Renal clearances of both radioisotope markers were virtually identical in patients and controls. Inasmuch as neither glomerular filtration rate nor effective renal plasma flow was enhanced in patients with cystic fibrosis, increased clearance of drugs in these patients is unlikely to be the result of enhanced glomerular filtration or tubular secretion.</description><subject>550901 - Pathology- Tracer Techniques</subject><subject>Adolescent</subject><subject>Adult</subject><subject>AMINO ACIDS</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL MATERIALS</subject><subject>BIOLOGICAL WASTES</subject><subject>BLOOD FLOW</subject><subject>BODY</subject><subject>BODY FLUIDS</subject><subject>CARBOXYLIC ACIDS</subject><subject>CHELATING AGENTS</subject><subject>CLEARANCE</subject><subject>Cystic Fibrosis - diagnostic imaging</subject><subject>Cystic Fibrosis - physiopathology</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DISEASES</subject><subject>DRUGS</subject><subject>DTPA</subject><subject>DYNAMIC FUNCTION STUDIES</subject><subject>ELECTRON CAPTURE RADIOISOTOPES</subject><subject>EXCRETION</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Glomerular Filtration Rate</subject><subject>HEREDITARY DISEASES</subject><subject>HOURS LIVING RADIOISOTOPES</subject><subject>Humans</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>IODINE 125</subject><subject>IODINE ISOTOPES</subject><subject>Iodine Radioisotopes</subject><subject>Iodohippuric Acid - blood</subject><subject>ISOMERIC NUCLEI</subject><subject>ISOMERIC TRANSITION ISOTOPES</subject><subject>ISOTOPE APPLICATIONS</subject><subject>ISOTOPES</subject><subject>Kidney - diagnostic imaging</subject><subject>Kidney - physiopathology</subject><subject>Kidney Tubules - physiopathology</subject><subject>KIDNEYS</subject><subject>LABELLED COMPOUNDS</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>MATERIALS</subject><subject>Mathematics</subject><subject>Medical sciences</subject><subject>Metabolic Clearance Rate</subject><subject>NUCLEI</subject><subject>ODD-EVEN NUCLEI</subject><subject>ORGANIC ACIDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANS</subject><subject>Other diseases. Semiology</subject><subject>PATIENTS</subject><subject>Pentetic Acid - blood</subject><subject>RADIOISOTOPES</subject><subject>Radionuclide Imaging</subject><subject>RADIOPROTECTIVE SUBSTANCES</subject><subject>Regional Blood Flow</subject><subject>RENAL CLEARANCE</subject><subject>Technetium - blood</subject><subject>TECHNETIUM 99</subject><subject>TECHNETIUM ISOTOPES</subject><subject>Technetium Tc 99m Pentetate</subject><subject>TRACER TECHNIQUES</subject><subject>URINE</subject><subject>WASTES</subject><subject>YEARS LIVING RADIOISOTOPES</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EKtvCT6hkIYTKIcWOE8c5oaoqH1IlDoUTB8uxx2Dk2Isn26r_Hqe72iunOcwz9vs-hJxzdskZlx_uGGvbRnSDvFD9e8Ukl416RjacjUMjlRDPyeaIvCSniH8YY2PH2Ak5EWrkY6c25OcVIiDOkBaaPf0V8wxlF02hPsSlmCXkROsAapKj4D3YJdwDLZBMpNtocDbUx_xAQ6L2EZdg6-VUMgZ8RV54ExFeH-YZ-fHp5vv1l-b22-ev11e3je24XJpJWdGKwU5STm0rpRCs7b2fBLet96xVEzjlfA8jGGfc1DthmBosMNWrbuDijLzZv5vr9xptWMD-tjmlmlX3LVe1bYXe7aFtyX93gIueA1qI0STIO9SD5EOVJivY70FbS2ABr7clzKY8as70al4_mderVq16_WReq3p3fvhgN83gjlcH1XX_9rA3aE30xSQb8IipriYd1pwf9xhUY_cByloIkgUXytrH5fCfIP8AaNOgjQ</recordid><startdate>198507</startdate><enddate>198507</enddate><creator>Spino, Michael</creator><creator>Chai, Roger P.</creator><creator>Isles, Alan F.</creator><creator>Balfe, J. Williamson</creator><creator>Brown, Robert G.</creator><creator>Thiessen, Jake J.</creator><creator>MacLeod, Stuart M.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>198507</creationdate><title>Assessment of glomerular filtration rate and effective renal plasma flow in cystic fibrosis</title><author>Spino, Michael ; Chai, Roger P. ; Isles, Alan F. ; Balfe, J. Williamson ; Brown, Robert G. ; Thiessen, Jake J. ; MacLeod, Stuart M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-b8c3237cb66b226633025ffb31c2ff028bed8df5e9eadadb5d3a087ce08584713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>550901 - Pathology- Tracer Techniques</topic><topic>Adolescent</topic><topic>Adult</topic><topic>AMINO ACIDS</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL MATERIALS</topic><topic>BIOLOGICAL WASTES</topic><topic>BLOOD FLOW</topic><topic>BODY</topic><topic>BODY FLUIDS</topic><topic>CARBOXYLIC ACIDS</topic><topic>CHELATING AGENTS</topic><topic>CLEARANCE</topic><topic>Cystic Fibrosis - diagnostic imaging</topic><topic>Cystic Fibrosis - physiopathology</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DISEASES</topic><topic>DRUGS</topic><topic>DTPA</topic><topic>DYNAMIC FUNCTION STUDIES</topic><topic>ELECTRON CAPTURE RADIOISOTOPES</topic><topic>EXCRETION</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Glomerular Filtration Rate</topic><topic>HEREDITARY DISEASES</topic><topic>HOURS LIVING RADIOISOTOPES</topic><topic>Humans</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>IODINE 125</topic><topic>IODINE ISOTOPES</topic><topic>Iodine Radioisotopes</topic><topic>Iodohippuric Acid - blood</topic><topic>ISOMERIC NUCLEI</topic><topic>ISOMERIC TRANSITION ISOTOPES</topic><topic>ISOTOPE APPLICATIONS</topic><topic>ISOTOPES</topic><topic>Kidney - diagnostic imaging</topic><topic>Kidney - physiopathology</topic><topic>Kidney Tubules - physiopathology</topic><topic>KIDNEYS</topic><topic>LABELLED COMPOUNDS</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>MATERIALS</topic><topic>Mathematics</topic><topic>Medical sciences</topic><topic>Metabolic Clearance Rate</topic><topic>NUCLEI</topic><topic>ODD-EVEN NUCLEI</topic><topic>ORGANIC ACIDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANS</topic><topic>Other diseases. Semiology</topic><topic>PATIENTS</topic><topic>Pentetic Acid - blood</topic><topic>RADIOISOTOPES</topic><topic>Radionuclide Imaging</topic><topic>RADIOPROTECTIVE SUBSTANCES</topic><topic>Regional Blood Flow</topic><topic>RENAL CLEARANCE</topic><topic>Technetium - blood</topic><topic>TECHNETIUM 99</topic><topic>TECHNETIUM ISOTOPES</topic><topic>Technetium Tc 99m Pentetate</topic><topic>TRACER TECHNIQUES</topic><topic>URINE</topic><topic>WASTES</topic><topic>YEARS LIVING RADIOISOTOPES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spino, Michael</creatorcontrib><creatorcontrib>Chai, Roger P.</creatorcontrib><creatorcontrib>Isles, Alan F.</creatorcontrib><creatorcontrib>Balfe, J. 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Williamson</au><au>Brown, Robert G.</au><au>Thiessen, Jake J.</au><au>MacLeod, Stuart M.</au><aucorp>Univ. of Toronto, Ontario, Canada</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of glomerular filtration rate and effective renal plasma flow in cystic fibrosis</atitle><jtitle>J. Pediatr.; (United States)</jtitle><addtitle>J Pediatr</addtitle><date>1985-07</date><risdate>1985</risdate><volume>107</volume><issue>1</issue><spage>64</spage><epage>70</epage><pages>64-70</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>A study was conducted to examine renal function in 10 healthy control subjects and eight patients with cystic fibrosis in stable condition. Sequential bolus injections of 99mTc-DTPA and 125I-OIH were administered to assess glomerular filtration rate and effective renal plasma flow, respectively. Blood was subsequently collected for 3 hours, and urine for 24 hours. Renal clearances of both radioisotope markers were virtually identical in patients and controls. Inasmuch as neither glomerular filtration rate nor effective renal plasma flow was enhanced in patients with cystic fibrosis, increased clearance of drugs in these patients is unlikely to be the result of enhanced glomerular filtration or tubular secretion.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>3891948</pmid><doi>10.1016/S0022-3476(85)80616-8</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3476 |
| ispartof | J. Pediatr.; (United States), 1985-07, Vol.107 (1), p.64-70 |
| issn | 0022-3476 1097-6833 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76178336 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | 550901 - Pathology- Tracer Techniques Adolescent Adult AMINO ACIDS BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Biological and medical sciences BIOLOGICAL MATERIALS BIOLOGICAL WASTES BLOOD FLOW BODY BODY FLUIDS CARBOXYLIC ACIDS CHELATING AGENTS CLEARANCE Cystic Fibrosis - diagnostic imaging Cystic Fibrosis - physiopathology DAYS LIVING RADIOISOTOPES DISEASES DRUGS DTPA DYNAMIC FUNCTION STUDIES ELECTRON CAPTURE RADIOISOTOPES EXCRETION Gastroenterology. Liver. Pancreas. Abdomen Glomerular Filtration Rate HEREDITARY DISEASES HOURS LIVING RADIOISOTOPES Humans INTERMEDIATE MASS NUCLEI IODINE 125 IODINE ISOTOPES Iodine Radioisotopes Iodohippuric Acid - blood ISOMERIC NUCLEI ISOMERIC TRANSITION ISOTOPES ISOTOPE APPLICATIONS ISOTOPES Kidney - diagnostic imaging Kidney - physiopathology Kidney Tubules - physiopathology KIDNEYS LABELLED COMPOUNDS Liver. Biliary tract. Portal circulation. Exocrine pancreas MATERIALS Mathematics Medical sciences Metabolic Clearance Rate NUCLEI ODD-EVEN NUCLEI ORGANIC ACIDS ORGANIC COMPOUNDS ORGANS Other diseases. Semiology PATIENTS Pentetic Acid - blood RADIOISOTOPES Radionuclide Imaging RADIOPROTECTIVE SUBSTANCES Regional Blood Flow RENAL CLEARANCE Technetium - blood TECHNETIUM 99 TECHNETIUM ISOTOPES Technetium Tc 99m Pentetate TRACER TECHNIQUES URINE WASTES YEARS LIVING RADIOISOTOPES |
| title | Assessment of glomerular filtration rate and effective renal plasma flow in cystic fibrosis |
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