Brain magnetic resonance imaging in non-alcoholic cirrhosis
Twenty-six patients with stable non-alcoholic cirrhosis and normal neurological examination were investigated by brain MRI (inversion recovery sequences) and compared with 16 controls. Brain MRI findings were correlated with the clinical and metabolic status of the patients and analysis of variance...
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| Veröffentlicht in: | European journal of radiology 1995-12, Vol.21 (2), p.84-88 |
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| container_title | European journal of radiology |
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| creator | Awada, Adnan Sullivan, Stephen Palkar, Vijay Sbeih, Fayez Naufal, Richard Rajeh, Saad Al |
| description | Twenty-six patients with stable non-alcoholic cirrhosis and normal neurological examination were investigated by brain MRI (inversion recovery sequences) and compared with 16 controls. Brain MRI findings were correlated with the clinical and metabolic status of the patients and analysis of variance and, when necessary, co-variance was performed. Five of the patients (19%) and all 16 controls showed no MRI changes. Twelve patients (46%) showed moderately high signal in the globus pallidus (score 1), and nine (35%) very high signal (score 2). Analysis of variance showed that age was the only significant variable (
P = 0.038). Analysis of co-variance after adjustment for age showed that high pallidal signal was correlated only to ammonia level (
P = 0.02) but not to any other clinical or biological parameter. We conclude that T1 high intensity pallidal signal is common in non-alcoholic cirrhosis even when neurological examination is normal, but its significance remains unclear. |
| doi_str_mv | 10.1016/0720-048X(95)00694-L |
| format | Article |
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P = 0.038). Analysis of co-variance after adjustment for age showed that high pallidal signal was correlated only to ammonia level (
P = 0.02) but not to any other clinical or biological parameter. We conclude that T1 high intensity pallidal signal is common in non-alcoholic cirrhosis even when neurological examination is normal, but its significance remains unclear.</description><identifier>ISSN: 0720-048X</identifier><identifier>EISSN: 1872-7727</identifier><identifier>DOI: 10.1016/0720-048X(95)00694-L</identifier><identifier>PMID: 8850497</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adult ; Age Factors ; Aged ; Ammonia - metabolism ; Analysis of Variance ; Bilirubin - blood ; Brain - metabolism ; Brain - pathology ; Brain, MR studies ; Female ; Globus Pallidus - metabolism ; Globus Pallidus - pathology ; Hepatitis B - complications ; Hepatitis C - complications ; Humans ; Image Enhancement ; Liver Cirrhosis - blood ; Liver Cirrhosis - etiology ; Liver Cirrhosis - metabolism ; Liver, disease ; Magnetic resonance (MR), brain ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neurologic Examination ; Prospective Studies ; Prothrombin Time ; Schistosomiasis - complications ; Serum Albumin - analysis</subject><ispartof>European journal of radiology, 1995-12, Vol.21 (2), p.84-88</ispartof><rights>1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-1de103abd64f28a997b60897fdbff5d4867ced7c09d8d264d115c53096e9cc073</citedby><cites>FETCH-LOGICAL-c357t-1de103abd64f28a997b60897fdbff5d4867ced7c09d8d264d115c53096e9cc073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0720-048X(95)00694-L$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8850497$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Awada, Adnan</creatorcontrib><creatorcontrib>Sullivan, Stephen</creatorcontrib><creatorcontrib>Palkar, Vijay</creatorcontrib><creatorcontrib>Sbeih, Fayez</creatorcontrib><creatorcontrib>Naufal, Richard</creatorcontrib><creatorcontrib>Rajeh, Saad Al</creatorcontrib><title>Brain magnetic resonance imaging in non-alcoholic cirrhosis</title><title>European journal of radiology</title><addtitle>Eur J Radiol</addtitle><description>Twenty-six patients with stable non-alcoholic cirrhosis and normal neurological examination were investigated by brain MRI (inversion recovery sequences) and compared with 16 controls. Brain MRI findings were correlated with the clinical and metabolic status of the patients and analysis of variance and, when necessary, co-variance was performed. Five of the patients (19%) and all 16 controls showed no MRI changes. Twelve patients (46%) showed moderately high signal in the globus pallidus (score 1), and nine (35%) very high signal (score 2). Analysis of variance showed that age was the only significant variable (
P = 0.038). Analysis of co-variance after adjustment for age showed that high pallidal signal was correlated only to ammonia level (
P = 0.02) but not to any other clinical or biological parameter. We conclude that T1 high intensity pallidal signal is common in non-alcoholic cirrhosis even when neurological examination is normal, but its significance remains unclear.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Ammonia - metabolism</subject><subject>Analysis of Variance</subject><subject>Bilirubin - blood</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Brain, MR studies</subject><subject>Female</subject><subject>Globus Pallidus - metabolism</subject><subject>Globus Pallidus - pathology</subject><subject>Hepatitis B - complications</subject><subject>Hepatitis C - complications</subject><subject>Humans</subject><subject>Image Enhancement</subject><subject>Liver Cirrhosis - blood</subject><subject>Liver Cirrhosis - etiology</subject><subject>Liver Cirrhosis - metabolism</subject><subject>Liver, disease</subject><subject>Magnetic resonance (MR), brain</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurologic Examination</subject><subject>Prospective Studies</subject><subject>Prothrombin Time</subject><subject>Schistosomiasis - complications</subject><subject>Serum Albumin - analysis</subject><issn>0720-048X</issn><issn>1872-7727</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEUhYMotVb_gcKsRBejNzOTF4KgxRcMuFFwF2aSTBuZJjWZCv57U1u6dHXhnnPu5XwInWK4woDpNbACcqj4x4UglwBUVHm9h8aYsyJnrGD7aLyzHKKjGD8BgFSiGKER5wQqwcbo5j401mWLZubMYFUWTPSuccpkNu2sm2VJdd7lTa_83PfJomwIcx9tPEYHXdNHc7KdE_T--PA2fc7r16eX6V2dq5KwIcfaYCibVtOqK3gjBGspcME63XYd0RWnTBnNFAjNdUErjTFRpARBjVAKWDlB55u7y-C_ViYOcmGjMn3fOONXUTKKGS8YTsZqY1TBxxhMJ5ch1Qg_EoNcM5NrIHINRAoi_5jJOsXOtvdX7cLoXWgLKem3G92kkt_WBBmVNYmRtsGoQWpv_3_wCwCme5s</recordid><startdate>19951215</startdate><enddate>19951215</enddate><creator>Awada, Adnan</creator><creator>Sullivan, Stephen</creator><creator>Palkar, Vijay</creator><creator>Sbeih, Fayez</creator><creator>Naufal, Richard</creator><creator>Rajeh, Saad Al</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19951215</creationdate><title>Brain magnetic resonance imaging in non-alcoholic cirrhosis</title><author>Awada, Adnan ; Sullivan, Stephen ; Palkar, Vijay ; Sbeih, Fayez ; Naufal, Richard ; Rajeh, Saad Al</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-1de103abd64f28a997b60897fdbff5d4867ced7c09d8d264d115c53096e9cc073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Ammonia - metabolism</topic><topic>Analysis of Variance</topic><topic>Bilirubin - blood</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Brain, MR studies</topic><topic>Female</topic><topic>Globus Pallidus - metabolism</topic><topic>Globus Pallidus - pathology</topic><topic>Hepatitis B - complications</topic><topic>Hepatitis C - complications</topic><topic>Humans</topic><topic>Image Enhancement</topic><topic>Liver Cirrhosis - blood</topic><topic>Liver Cirrhosis - etiology</topic><topic>Liver Cirrhosis - metabolism</topic><topic>Liver, disease</topic><topic>Magnetic resonance (MR), brain</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurologic Examination</topic><topic>Prospective Studies</topic><topic>Prothrombin Time</topic><topic>Schistosomiasis - complications</topic><topic>Serum Albumin - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Awada, Adnan</creatorcontrib><creatorcontrib>Sullivan, Stephen</creatorcontrib><creatorcontrib>Palkar, Vijay</creatorcontrib><creatorcontrib>Sbeih, Fayez</creatorcontrib><creatorcontrib>Naufal, Richard</creatorcontrib><creatorcontrib>Rajeh, Saad Al</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Awada, Adnan</au><au>Sullivan, Stephen</au><au>Palkar, Vijay</au><au>Sbeih, Fayez</au><au>Naufal, Richard</au><au>Rajeh, Saad Al</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain magnetic resonance imaging in non-alcoholic cirrhosis</atitle><jtitle>European journal of radiology</jtitle><addtitle>Eur J Radiol</addtitle><date>1995-12-15</date><risdate>1995</risdate><volume>21</volume><issue>2</issue><spage>84</spage><epage>88</epage><pages>84-88</pages><issn>0720-048X</issn><eissn>1872-7727</eissn><abstract>Twenty-six patients with stable non-alcoholic cirrhosis and normal neurological examination were investigated by brain MRI (inversion recovery sequences) and compared with 16 controls. Brain MRI findings were correlated with the clinical and metabolic status of the patients and analysis of variance and, when necessary, co-variance was performed. Five of the patients (19%) and all 16 controls showed no MRI changes. Twelve patients (46%) showed moderately high signal in the globus pallidus (score 1), and nine (35%) very high signal (score 2). Analysis of variance showed that age was the only significant variable (
P = 0.038). Analysis of co-variance after adjustment for age showed that high pallidal signal was correlated only to ammonia level (
P = 0.02) but not to any other clinical or biological parameter. We conclude that T1 high intensity pallidal signal is common in non-alcoholic cirrhosis even when neurological examination is normal, but its significance remains unclear.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>8850497</pmid><doi>10.1016/0720-048X(95)00694-L</doi><tpages>5</tpages></addata></record> |
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| ispartof | European journal of radiology, 1995-12, Vol.21 (2), p.84-88 |
| issn | 0720-048X 1872-7727 |
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| subjects | Adult Age Factors Aged Ammonia - metabolism Analysis of Variance Bilirubin - blood Brain - metabolism Brain - pathology Brain, MR studies Female Globus Pallidus - metabolism Globus Pallidus - pathology Hepatitis B - complications Hepatitis C - complications Humans Image Enhancement Liver Cirrhosis - blood Liver Cirrhosis - etiology Liver Cirrhosis - metabolism Liver, disease Magnetic resonance (MR), brain Magnetic Resonance Imaging Male Middle Aged Neurologic Examination Prospective Studies Prothrombin Time Schistosomiasis - complications Serum Albumin - analysis |
| title | Brain magnetic resonance imaging in non-alcoholic cirrhosis |
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