Impact of organosulfur compounds in garlic on canine mammary tumor cells in culture
Six organosulfur compounds found in garlic were examined for their ability to alter the growth of canine mammary tumor cells (CMT-13) in culture. Water-soluble organosulfur compounds ( S-allyl-cysteine, S-ethyl-cysteine and S-propyl-cysteine) did not significantly alter the growth of CMT-13 cells wh...
Gespeichert in:
| Veröffentlicht in: | Cancer letters 1993-10, Vol.74 (1), p.85-90 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 90 |
|---|---|
| container_issue | 1 |
| container_start_page | 85 |
| container_title | Cancer letters |
| container_volume | 74 |
| creator | Sundaram, Sujatha G. Milner, John A. |
| description | Six organosulfur compounds found in garlic were examined for their ability to alter the growth of canine mammary tumor cells (CMT-13) in culture. Water-soluble organosulfur compounds (
S-allyl-cysteine,
S-ethyl-cysteine and
S-propyl-cysteine) did not significantly alter the growth of CMT-13 cells when added to cultures at 1.0 mM or less. However, oil-soluble organosulfur compounds (diallyl sulfide, diallyl disulfide and diallyl trisulfide) markedly inhibited growth. Increasing addition of diallyl disulfide (DADS) resulted in a progressive decrease in CMT-13 cell growth. Addition of glutathione before DADS markedly decreased the severity of the growth inhibition. Treatment with DL-buthionine-SR-sulfoxamine, a specific inhibitor of glutathione synthesis, accentuated the growth inhibition caused by DADS. These studies show that some organosulfur compounds found in garlic are effective inhibitors of the growth of the neoplastic CMT-13 cell. The inhibitory effects of these compounds are modified by intracellular glutathione. |
| doi_str_mv | 10.1016/0304-3835(93)90048-E |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76177734</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>030438359390048E</els_id><sourcerecordid>76177734</sourcerecordid><originalsourceid>FETCH-LOGICAL-c503t-a1b3134533548c44284daceadb40a87eb82d435232c3d73b95bf15e7a863e7813</originalsourceid><addsrcrecordid>eNp9kE1r3DAQhkVJSDZJ_0EDOpSQHNxIHmklXwolbD4g0EOTs5DlcVCxpa1kFfrva2eXPeY0h3ne4Z2HkC-cfeOMr28ZMFGBBnndwE3DmNDV5hNZca3qSjWaHZHVATklZzn_ZoxJoeQJOdG1VqDWK_LradxaN9HY05jebIi5DH1J1MVxG0voMvWBvtk0eEdjoM4GH5COdhxt-kenMsaZxWF451wZppLwghz3dsj4eT_Pyev95uXusXr--fB09-O5cpLBVFneAgchAaTQTohai846tF0rmNUKW113AmQNtYNOQdvItucSldVrQKU5nJOr3d1tin8K5smMPi9lbMBYslFrrpQCMYNiB7oUc07Ym23yywOGM7O4NIsos4gyDZh3l2Yzxy7390s7YncI7eXN-6_7vc3ODn2ywfl8wGCuyNVS8_sOw9nFX4_JZOcxOOx8QjeZLvqPe_wHVDiP1g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76177734</pqid></control><display><type>article</type><title>Impact of organosulfur compounds in garlic on canine mammary tumor cells in culture</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Sundaram, Sujatha G. ; Milner, John A.</creator><creatorcontrib>Sundaram, Sujatha G. ; Milner, John A.</creatorcontrib><description>Six organosulfur compounds found in garlic were examined for their ability to alter the growth of canine mammary tumor cells (CMT-13) in culture. Water-soluble organosulfur compounds (
S-allyl-cysteine,
S-ethyl-cysteine and
S-propyl-cysteine) did not significantly alter the growth of CMT-13 cells when added to cultures at 1.0 mM or less. However, oil-soluble organosulfur compounds (diallyl sulfide, diallyl disulfide and diallyl trisulfide) markedly inhibited growth. Increasing addition of diallyl disulfide (DADS) resulted in a progressive decrease in CMT-13 cell growth. Addition of glutathione before DADS markedly decreased the severity of the growth inhibition. Treatment with DL-buthionine-SR-sulfoxamine, a specific inhibitor of glutathione synthesis, accentuated the growth inhibition caused by DADS. These studies show that some organosulfur compounds found in garlic are effective inhibitors of the growth of the neoplastic CMT-13 cell. The inhibitory effects of these compounds are modified by intracellular glutathione.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/0304-3835(93)90048-E</identifier><identifier>PMID: 8287376</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Allyl Compounds - pharmacology ; Analysis of Variance ; Animals ; Anticarcinogenic Agents - pharmacology ; Biological and medical sciences ; Cell Division - drug effects ; Cysteine - analogs & derivatives ; Cysteine - pharmacology ; Diallyl disulfide ; Disulfides - pharmacology ; Dogs ; Female ; Garlic ; General pharmacology ; Glutathione ; Glutathione - metabolism ; Glutathione - pharmacology ; Growth ; Growth Inhibitors - pharmacology ; Mammary Neoplasms, Experimental - drug therapy ; Mammary Neoplasms, Experimental - physiopathology ; Mammary tumor cells ; Medical sciences ; Organosulfur compounds ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Oils - pharmacology ; Plants, Medicinal ; Sulfides - pharmacology ; Sulfur - pharmacology ; Tumor Cells, Cultured - drug effects</subject><ispartof>Cancer letters, 1993-10, Vol.74 (1), p.85-90</ispartof><rights>1993</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-a1b3134533548c44284daceadb40a87eb82d435232c3d73b95bf15e7a863e7813</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-3835(93)90048-E$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3813171$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8287376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sundaram, Sujatha G.</creatorcontrib><creatorcontrib>Milner, John A.</creatorcontrib><title>Impact of organosulfur compounds in garlic on canine mammary tumor cells in culture</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Six organosulfur compounds found in garlic were examined for their ability to alter the growth of canine mammary tumor cells (CMT-13) in culture. Water-soluble organosulfur compounds (
S-allyl-cysteine,
S-ethyl-cysteine and
S-propyl-cysteine) did not significantly alter the growth of CMT-13 cells when added to cultures at 1.0 mM or less. However, oil-soluble organosulfur compounds (diallyl sulfide, diallyl disulfide and diallyl trisulfide) markedly inhibited growth. Increasing addition of diallyl disulfide (DADS) resulted in a progressive decrease in CMT-13 cell growth. Addition of glutathione before DADS markedly decreased the severity of the growth inhibition. Treatment with DL-buthionine-SR-sulfoxamine, a specific inhibitor of glutathione synthesis, accentuated the growth inhibition caused by DADS. These studies show that some organosulfur compounds found in garlic are effective inhibitors of the growth of the neoplastic CMT-13 cell. The inhibitory effects of these compounds are modified by intracellular glutathione.</description><subject>Allyl Compounds - pharmacology</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Anticarcinogenic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Division - drug effects</subject><subject>Cysteine - analogs & derivatives</subject><subject>Cysteine - pharmacology</subject><subject>Diallyl disulfide</subject><subject>Disulfides - pharmacology</subject><subject>Dogs</subject><subject>Female</subject><subject>Garlic</subject><subject>General pharmacology</subject><subject>Glutathione</subject><subject>Glutathione - metabolism</subject><subject>Glutathione - pharmacology</subject><subject>Growth</subject><subject>Growth Inhibitors - pharmacology</subject><subject>Mammary Neoplasms, Experimental - drug therapy</subject><subject>Mammary Neoplasms, Experimental - physiopathology</subject><subject>Mammary tumor cells</subject><subject>Medical sciences</subject><subject>Organosulfur compounds</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Oils - pharmacology</subject><subject>Plants, Medicinal</subject><subject>Sulfides - pharmacology</subject><subject>Sulfur - pharmacology</subject><subject>Tumor Cells, Cultured - drug effects</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVJSDZJ_0EDOpSQHNxIHmklXwolbD4g0EOTs5DlcVCxpa1kFfrva2eXPeY0h3ne4Z2HkC-cfeOMr28ZMFGBBnndwE3DmNDV5hNZca3qSjWaHZHVATklZzn_ZoxJoeQJOdG1VqDWK_LradxaN9HY05jebIi5DH1J1MVxG0voMvWBvtk0eEdjoM4GH5COdhxt-kenMsaZxWF451wZppLwghz3dsj4eT_Pyev95uXusXr--fB09-O5cpLBVFneAgchAaTQTohai846tF0rmNUKW113AmQNtYNOQdvItucSldVrQKU5nJOr3d1tin8K5smMPi9lbMBYslFrrpQCMYNiB7oUc07Ym23yywOGM7O4NIsos4gyDZh3l2Yzxy7390s7YncI7eXN-6_7vc3ODn2ywfl8wGCuyNVS8_sOw9nFX4_JZOcxOOx8QjeZLvqPe_wHVDiP1g</recordid><startdate>19931015</startdate><enddate>19931015</enddate><creator>Sundaram, Sujatha G.</creator><creator>Milner, John A.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19931015</creationdate><title>Impact of organosulfur compounds in garlic on canine mammary tumor cells in culture</title><author>Sundaram, Sujatha G. ; Milner, John A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-a1b3134533548c44284daceadb40a87eb82d435232c3d73b95bf15e7a863e7813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Allyl Compounds - pharmacology</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Anticarcinogenic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cell Division - drug effects</topic><topic>Cysteine - analogs & derivatives</topic><topic>Cysteine - pharmacology</topic><topic>Diallyl disulfide</topic><topic>Disulfides - pharmacology</topic><topic>Dogs</topic><topic>Female</topic><topic>Garlic</topic><topic>General pharmacology</topic><topic>Glutathione</topic><topic>Glutathione - metabolism</topic><topic>Glutathione - pharmacology</topic><topic>Growth</topic><topic>Growth Inhibitors - pharmacology</topic><topic>Mammary Neoplasms, Experimental - drug therapy</topic><topic>Mammary Neoplasms, Experimental - physiopathology</topic><topic>Mammary tumor cells</topic><topic>Medical sciences</topic><topic>Organosulfur compounds</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Oils - pharmacology</topic><topic>Plants, Medicinal</topic><topic>Sulfides - pharmacology</topic><topic>Sulfur - pharmacology</topic><topic>Tumor Cells, Cultured - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sundaram, Sujatha G.</creatorcontrib><creatorcontrib>Milner, John A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sundaram, Sujatha G.</au><au>Milner, John A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of organosulfur compounds in garlic on canine mammary tumor cells in culture</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1993-10-15</date><risdate>1993</risdate><volume>74</volume><issue>1</issue><spage>85</spage><epage>90</epage><pages>85-90</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>Six organosulfur compounds found in garlic were examined for their ability to alter the growth of canine mammary tumor cells (CMT-13) in culture. Water-soluble organosulfur compounds (
S-allyl-cysteine,
S-ethyl-cysteine and
S-propyl-cysteine) did not significantly alter the growth of CMT-13 cells when added to cultures at 1.0 mM or less. However, oil-soluble organosulfur compounds (diallyl sulfide, diallyl disulfide and diallyl trisulfide) markedly inhibited growth. Increasing addition of diallyl disulfide (DADS) resulted in a progressive decrease in CMT-13 cell growth. Addition of glutathione before DADS markedly decreased the severity of the growth inhibition. Treatment with DL-buthionine-SR-sulfoxamine, a specific inhibitor of glutathione synthesis, accentuated the growth inhibition caused by DADS. These studies show that some organosulfur compounds found in garlic are effective inhibitors of the growth of the neoplastic CMT-13 cell. The inhibitory effects of these compounds are modified by intracellular glutathione.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>8287376</pmid><doi>10.1016/0304-3835(93)90048-E</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 1993-10, Vol.74 (1), p.85-90 |
| issn | 0304-3835 1872-7980 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76177734 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Allyl Compounds - pharmacology Analysis of Variance Animals Anticarcinogenic Agents - pharmacology Biological and medical sciences Cell Division - drug effects Cysteine - analogs & derivatives Cysteine - pharmacology Diallyl disulfide Disulfides - pharmacology Dogs Female Garlic General pharmacology Glutathione Glutathione - metabolism Glutathione - pharmacology Growth Growth Inhibitors - pharmacology Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - physiopathology Mammary tumor cells Medical sciences Organosulfur compounds Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Oils - pharmacology Plants, Medicinal Sulfides - pharmacology Sulfur - pharmacology Tumor Cells, Cultured - drug effects |
| title | Impact of organosulfur compounds in garlic on canine mammary tumor cells in culture |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T10%3A21%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20organosulfur%20compounds%20in%20garlic%20on%20canine%20mammary%20tumor%20cells%20in%20culture&rft.jtitle=Cancer%20letters&rft.au=Sundaram,%20Sujatha%20G.&rft.date=1993-10-15&rft.volume=74&rft.issue=1&rft.spage=85&rft.epage=90&rft.pages=85-90&rft.issn=0304-3835&rft.eissn=1872-7980&rft.coden=CALEDQ&rft_id=info:doi/10.1016/0304-3835(93)90048-E&rft_dat=%3Cproquest_cross%3E76177734%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76177734&rft_id=info:pmid/8287376&rft_els_id=030438359390048E&rfr_iscdi=true |