Preparation of 20-(hydroxymethyl)-4-methyl-4-aza-2-oxa-5α-pregnan-3-one as an inhibitor of testosterone 5α-reductase

20-(Hydroxymethyl)-4-methyl-4-aza-2-oxa-5 alpha-pregnan-3-one and the corresponding 3-thione were synthesized with use of 20-(hydroxymethyl)-4-methyl-4-aza-5 alpha-pregnan-3-one as the starting material. The compounds were tested in vitro for inhibition of testosterone 5 alpha-reductase and found to...

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Veröffentlicht in:	Journal of medicinal chemistry 1985-06, Vol.28 (6), p.831-833
Hauptverfasser:	WEINTRAUB, P. M, BLOHM, T. R, LAUGHLIN, M
Format:	Artikel
Sprache:	eng
Schlagworte:	5-alpha Reductase Inhibitors Alicyclic compounds, terpenoids, prostaglandins, steroids Animals Chemistry Enzyme Inhibitors - chemical synthesis Exact sciences and technology In Vitro Techniques Kinetics Male Organic chemistry Oxidoreductases - antagonists & inhibitors Pregnanes - chemical synthesis Pregnanes - pharmacology Preparations and properties Prostate - enzymology Rats Steroids Steroids, Heterocyclic - chemical synthesis Steroids, Heterocyclic - pharmacology
Online-Zugang:	Volltext
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