Phenotypic Properties of Atypical Lymphocytes in Cytomegalovirus-Induced Mononucleosis
The phenotypic properties of the surface of the atypical lymphocytes seen in cytomegalovirus-induced(CMV)mononucleosis were evaluated. Mononuclear cells from peripheral blood were obtained from adult patients within seven to 35 days of the onset of acute CMV mononucleosis. Sheep red blood cell roset...
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| Veröffentlicht in: | The Journal of infectious diseases 1985-07, Vol.152 (1), p.198-203 |
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| creator | Felsenstein, Donna Carney, Walter P. Iacoviello, Vito R. Hirsch, Martin S. |
| description | The phenotypic properties of the surface of the atypical lymphocytes seen in cytomegalovirus-induced(CMV)mononucleosis were evaluated. Mononuclear cells from peripheral blood were obtained from adult patients within seven to 35 days of the onset of acute CMV mononucleosis. Sheep red blood cell rosetting techniques were used to obtain populations depleted of, or enriched for, T cells. Cell populations were further purified for helper/inducer lymphocytes(T4), cytotoxic/suppressor lymphocytes(T8), or non-T lymphocytesby monoclonal-antibody binding and by complement-lysis techniques. Cytocentrifuge preparations of the cell fractions were evaluated and atypical lymphocytes were identified by morphological characteristics. The appearance and disappearance of atypical lymphocytes paralleled and antedated the increase and subsequent decrease in T8 cells seen in these patients. A total of 69% ± 22% of the atypical lymphocytes in the lymphocyte population were of the T8 phenotype, whereas 13% ± 10% of the atypical lymphocytes were of the T4 phenotype and 18% ± 13%were non-T lymphocytes. Thus, atypical lymphocytes in CMV mononucleosis reside predominantly, but not exclusively, in the T8 cell population. |
| doi_str_mv | 10.1093/infdis/152.1.198 |
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Mononuclear cells from peripheral blood were obtained from adult patients within seven to 35 days of the onset of acute CMV mononucleosis. Sheep red blood cell rosetting techniques were used to obtain populations depleted of, or enriched for, T cells. Cell populations were further purified for helper/inducer lymphocytes(T4), cytotoxic/suppressor lymphocytes(T8), or non-T lymphocytesby monoclonal-antibody binding and by complement-lysis techniques. Cytocentrifuge preparations of the cell fractions were evaluated and atypical lymphocytes were identified by morphological characteristics. The appearance and disappearance of atypical lymphocytes paralleled and antedated the increase and subsequent decrease in T8 cells seen in these patients. A total of 69% ± 22% of the atypical lymphocytes in the lymphocyte population were of the T8 phenotype, whereas 13% ± 10% of the atypical lymphocytes were of the T4 phenotype and 18% ± 13%were non-T lymphocytes. Thus, atypical lymphocytes in CMV mononucleosis reside predominantly, but not exclusively, in the T8 cell population.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/152.1.198</identifier><identifier>PMID: 2989382</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Antibodies ; B lymphocytes ; Biological and medical sciences ; Blood ; Cytomegalovirus ; Cytomegalovirus - isolation & purification ; Embryonic cells ; Erythrocytes ; Human viral diseases ; Humans ; Infectious diseases ; Infectious Mononucleosis - blood ; Infectious Mononucleosis - microbiology ; Leukocyte Count ; Leukocytes ; Lymphocytes ; Lymphocytes - pathology ; Medical sciences ; Monoclonal antibodies ; Original Articles ; Phenotype ; T lymphocytes ; T-Lymphocytes - classification ; T-Lymphocytes - pathology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>The Journal of infectious diseases, 1985-07, Vol.152 (1), p.198-203</ispartof><rights>Copyright 1985 The University of Chicago</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-a952567a583b64769e1ff81d2962fec0d9a26e6e007ccd5cc8ca421c6a1a13b73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30104657$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30104657$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8481531$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2989382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Felsenstein, Donna</creatorcontrib><creatorcontrib>Carney, Walter P.</creatorcontrib><creatorcontrib>Iacoviello, Vito R.</creatorcontrib><creatorcontrib>Hirsch, Martin S.</creatorcontrib><title>Phenotypic Properties of Atypical Lymphocytes in Cytomegalovirus-Induced Mononucleosis</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>The phenotypic properties of the surface of the atypical lymphocytes seen in cytomegalovirus-induced(CMV)mononucleosis were evaluated. Mononuclear cells from peripheral blood were obtained from adult patients within seven to 35 days of the onset of acute CMV mononucleosis. Sheep red blood cell rosetting techniques were used to obtain populations depleted of, or enriched for, T cells. Cell populations were further purified for helper/inducer lymphocytes(T4), cytotoxic/suppressor lymphocytes(T8), or non-T lymphocytesby monoclonal-antibody binding and by complement-lysis techniques. Cytocentrifuge preparations of the cell fractions were evaluated and atypical lymphocytes were identified by morphological characteristics. The appearance and disappearance of atypical lymphocytes paralleled and antedated the increase and subsequent decrease in T8 cells seen in these patients. A total of 69% ± 22% of the atypical lymphocytes in the lymphocyte population were of the T8 phenotype, whereas 13% ± 10% of the atypical lymphocytes were of the T4 phenotype and 18% ± 13%were non-T lymphocytes. Thus, atypical lymphocytes in CMV mononucleosis reside predominantly, but not exclusively, in the T8 cell population.</description><subject>Adult</subject><subject>Antibodies</subject><subject>B lymphocytes</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus - isolation & purification</subject><subject>Embryonic cells</subject><subject>Erythrocytes</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Infectious Mononucleosis - blood</subject><subject>Infectious Mononucleosis - microbiology</subject><subject>Leukocyte Count</subject><subject>Leukocytes</subject><subject>Lymphocytes</subject><subject>Lymphocytes - pathology</subject><subject>Medical sciences</subject><subject>Monoclonal antibodies</subject><subject>Original Articles</subject><subject>Phenotype</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes - classification</subject><subject>T-Lymphocytes - pathology</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAURS0EKtPCng1SFohdpn52_LWsRtCpNIiqKgWxsTyOQ12SOLUT1Px73M4wLLuy9M59V_J5CL0DvASs6Knvm9qnU2BkCUtQ8gVaAKOi5BzoS7TAmJASpFKv0XFKdxjjinJxhI6IkopKskA3l7euD-M8eFtcxjC4OHqXitAUZ09D0xabuRtug53HPPd9sZrH0Llfpg1_fJxSedHXk3V18SX0oZ9s60Ly6Q161Zg2ubf79wR9-_zperUuN1_PL1Znm9IyQsbSKEYYF4ZJuuWV4MpB00ioieKkcRbXyhDuuMNYWFsza6U1FQHLDRigW0FP0Mdd7xDD_eTSqDufrGtb07swJS04CIEpeTYIFaGs4jwH8S5oY0gpukYP0XcmzhqwfnSud851dq5BZ-d55f2-e9p2rj4s7CVn_mHPTcpCm2h6mwv-xWQl883gf81dGkM8YIoBV5w9_rXccZ9G93DgJv7WXFDB9PrHT32Nr-RanX_Xgv4F9V-lKQ</recordid><startdate>198507</startdate><enddate>198507</enddate><creator>Felsenstein, Donna</creator><creator>Carney, Walter P.</creator><creator>Iacoviello, Vito R.</creator><creator>Hirsch, Martin S.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>198507</creationdate><title>Phenotypic Properties of Atypical Lymphocytes in Cytomegalovirus-Induced Mononucleosis</title><author>Felsenstein, Donna ; Carney, Walter P. ; Iacoviello, Vito R. ; Hirsch, Martin S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-a952567a583b64769e1ff81d2962fec0d9a26e6e007ccd5cc8ca421c6a1a13b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Antibodies</topic><topic>B lymphocytes</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Cytomegalovirus</topic><topic>Cytomegalovirus - isolation & purification</topic><topic>Embryonic cells</topic><topic>Erythrocytes</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Infectious Mononucleosis - blood</topic><topic>Infectious Mononucleosis - microbiology</topic><topic>Leukocyte Count</topic><topic>Leukocytes</topic><topic>Lymphocytes</topic><topic>Lymphocytes - pathology</topic><topic>Medical sciences</topic><topic>Monoclonal antibodies</topic><topic>Original Articles</topic><topic>Phenotype</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes - classification</topic><topic>T-Lymphocytes - pathology</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Felsenstein, Donna</creatorcontrib><creatorcontrib>Carney, Walter P.</creatorcontrib><creatorcontrib>Iacoviello, Vito R.</creatorcontrib><creatorcontrib>Hirsch, Martin S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Felsenstein, Donna</au><au>Carney, Walter P.</au><au>Iacoviello, Vito R.</au><au>Hirsch, Martin S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phenotypic Properties of Atypical Lymphocytes in Cytomegalovirus-Induced Mononucleosis</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1985-07</date><risdate>1985</risdate><volume>152</volume><issue>1</issue><spage>198</spage><epage>203</epage><pages>198-203</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>The phenotypic properties of the surface of the atypical lymphocytes seen in cytomegalovirus-induced(CMV)mononucleosis were evaluated. Mononuclear cells from peripheral blood were obtained from adult patients within seven to 35 days of the onset of acute CMV mononucleosis. Sheep red blood cell rosetting techniques were used to obtain populations depleted of, or enriched for, T cells. Cell populations were further purified for helper/inducer lymphocytes(T4), cytotoxic/suppressor lymphocytes(T8), or non-T lymphocytesby monoclonal-antibody binding and by complement-lysis techniques. Cytocentrifuge preparations of the cell fractions were evaluated and atypical lymphocytes were identified by morphological characteristics. The appearance and disappearance of atypical lymphocytes paralleled and antedated the increase and subsequent decrease in T8 cells seen in these patients. A total of 69% ± 22% of the atypical lymphocytes in the lymphocyte population were of the T8 phenotype, whereas 13% ± 10% of the atypical lymphocytes were of the T4 phenotype and 18% ± 13%were non-T lymphocytes. Thus, atypical lymphocytes in CMV mononucleosis reside predominantly, but not exclusively, in the T8 cell population.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>2989382</pmid><doi>10.1093/infdis/152.1.198</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 1985-07, Vol.152 (1), p.198-203 |
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| language | eng |
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| subjects | Adult Antibodies B lymphocytes Biological and medical sciences Blood Cytomegalovirus Cytomegalovirus - isolation & purification Embryonic cells Erythrocytes Human viral diseases Humans Infectious diseases Infectious Mononucleosis - blood Infectious Mononucleosis - microbiology Leukocyte Count Leukocytes Lymphocytes Lymphocytes - pathology Medical sciences Monoclonal antibodies Original Articles Phenotype T lymphocytes T-Lymphocytes - classification T-Lymphocytes - pathology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Phenotypic Properties of Atypical Lymphocytes in Cytomegalovirus-Induced Mononucleosis |
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