Cyclic AMP induces terminal deoxynucleotidyl transferase in immature B cell leukemia lines

Terminal deoxynucleotidyl transferase (Tdt), a unique DNA polymerase found only in lymphoid cells, may be involved in the generation of immunoglobulin-combining site diversity. To study the actual metabolic function of the enzyme, we developed a system in which Tdt expression is induced under define...

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Veröffentlicht in:	The Journal of immunology (1950) 1985-08, Vol.135 (2), p.1518-1522
Hauptverfasser:	Siden, EJ, Gifford, A, Baltimore, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - enzymology B-Lymphocytes - immunology Biological and medical sciences Bucladesine - pharmacology Caffeine - pharmacology Cell Line Cyclic AMP - physiology DNA Nucleotidylexotransferase - biosynthesis DNA Nucleotidyltransferases - biosynthesis Enzyme Activation - drug effects Fetus General aspects (metabolism, cell proliferation, established cell line...) Humans Immunoglobulin M - biosynthesis Kinetics Leukemia - enzymology Leukemia - immunology Lipopolysaccharides - pharmacology Liver Neoplasms - enzymology Liver Neoplasms - immunology Medical sciences Mice Mice, Inbred BALB C Tumor cell Tumors
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