Induction of interleukin 1 secretion by murine macrophages and human monocytes after stimulation by RU 41740, a bacterial immunomodulator
RU 41740, a glycoprotein extract from K. pneumoniae K 2O 1 strain, is an immunomodulating compound which has been shown to reduce infectious episodes in patients prone to recurrent infections. Data from preliminary experiments suggest that RU 41740 may affect several target cells, including T cells,...
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| Veröffentlicht in: | International journal of immunopharmacology 1985, Vol.7 (2), p.287-290 |
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| container_title | International journal of immunopharmacology |
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| creator | Guenounou, Moncef Vacheron, Françoise Nauciel, Charles Agneray, Jean |
| description | RU 41740, a glycoprotein extract from
K. pneumoniae K
2O
1 strain, is an immunomodulating compound which has been shown to reduce infectious episodes in patients prone to recurrent infections. Data from preliminary experiments suggest that RU 41740 may affect several target cells, including T cells, B cells or macrophages. In the present report we show that RU 41740 can trigger mouse macrophages and human adherent mononuclear cells to produce interleukin 1 activity. Indeed, supernatants from mouse peritoneal adherent cells and human monocytes incubated in presence of RU 41740, can stimulate blastogenesis in thymocytes from C3H/HeJ mice. The data suggest that the immunomodulating effect of RU 41740 could be related to its ability to induce interleukin 1 production. |
| doi_str_mv | 10.1016/0192-0561(85)90038-4 |
| format | Article |
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K. pneumoniae K
2O
1 strain, is an immunomodulating compound which has been shown to reduce infectious episodes in patients prone to recurrent infections. Data from preliminary experiments suggest that RU 41740 may affect several target cells, including T cells, B cells or macrophages. In the present report we show that RU 41740 can trigger mouse macrophages and human adherent mononuclear cells to produce interleukin 1 activity. Indeed, supernatants from mouse peritoneal adherent cells and human monocytes incubated in presence of RU 41740, can stimulate blastogenesis in thymocytes from C3H/HeJ mice. The data suggest that the immunomodulating effect of RU 41740 could be related to its ability to induce interleukin 1 production.</description><identifier>ISSN: 0192-0561</identifier><identifier>EISSN: 1879-3495</identifier><identifier>DOI: 10.1016/0192-0561(85)90038-4</identifier><identifier>PMID: 3874176</identifier><identifier>CODEN: IJIMDS</identifier><language>eng</language><publisher>Oxford: Elsevier Science</publisher><subject>Animals ; Bacterial Proteins ; Biological and medical sciences ; Cells, Cultured ; Female ; Glycoproteins - pharmacology ; Humans ; Immunity, Cellular - drug effects ; Immunomodulators ; Interleukin-1 - metabolism ; Macrophages - drug effects ; Macrophages - immunology ; Male ; Medical sciences ; Mice ; Mice, Inbred C3H ; Mice, Inbred DBA ; Monocytes - drug effects ; Monocytes - immunology ; Pharmacology. Drug treatments ; Stimulation, Chemical</subject><ispartof>International journal of immunopharmacology, 1985, Vol.7 (2), p.287-290</ispartof><rights>1985</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-56dcb495bc0d6fff8ea09015d73acb571f5876ddaaff4c2ef1e371be5c607b033</citedby><cites>FETCH-LOGICAL-c301t-56dcb495bc0d6fff8ea09015d73acb571f5876ddaaff4c2ef1e371be5c607b033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9171949$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3874176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guenounou, Moncef</creatorcontrib><creatorcontrib>Vacheron, Françoise</creatorcontrib><creatorcontrib>Nauciel, Charles</creatorcontrib><creatorcontrib>Agneray, Jean</creatorcontrib><title>Induction of interleukin 1 secretion by murine macrophages and human monocytes after stimulation by RU 41740, a bacterial immunomodulator</title><title>International journal of immunopharmacology</title><addtitle>Int J Immunopharmacol</addtitle><description>RU 41740, a glycoprotein extract from
K. pneumoniae K
2O
1 strain, is an immunomodulating compound which has been shown to reduce infectious episodes in patients prone to recurrent infections. Data from preliminary experiments suggest that RU 41740 may affect several target cells, including T cells, B cells or macrophages. In the present report we show that RU 41740 can trigger mouse macrophages and human adherent mononuclear cells to produce interleukin 1 activity. Indeed, supernatants from mouse peritoneal adherent cells and human monocytes incubated in presence of RU 41740, can stimulate blastogenesis in thymocytes from C3H/HeJ mice. The data suggest that the immunomodulating effect of RU 41740 could be related to its ability to induce interleukin 1 production.</description><subject>Animals</subject><subject>Bacterial Proteins</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Female</subject><subject>Glycoproteins - pharmacology</subject><subject>Humans</subject><subject>Immunity, Cellular - drug effects</subject><subject>Immunomodulators</subject><subject>Interleukin-1 - metabolism</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Mice, Inbred DBA</subject><subject>Monocytes - drug effects</subject><subject>Monocytes - immunology</subject><subject>Pharmacology. Drug treatments</subject><subject>Stimulation, Chemical</subject><issn>0192-0561</issn><issn>1879-3495</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd2KFDEQhYMo6-zqGyjkQmQFW5Pp_HTfCLL4s7AgiHsd0knFjXaSMekI8wi-temdcS69CtT56qTqFELPKHlDCRVvCR23HeGCXg781UhIP3TsAdrQQY5dz0b-EG1OyGN0XsoPQginYnuGzvpBMirFBv25jraaxaeIk8M-LpBnqD99xBQXMBnupWmPQ80-Ag7a5LS709-hYB0tvqtBRxxSTGa_rDXXHHBZfKiz_tf79Ra33xh5jTWetGmE1zP2IdSYQrIrmfIT9MjpucDT43uBbj9--Hb1ubv58un66v1NZ3pCl44La6a23WSIFc65ATQZCeVW9tpMXFLHByms1do5ZrbgKPSSTsCNIHIifX-BXh58dzn9qlAWFXwxMM86QqpFSdFGZdsVZAewbVxKBqd22Qed94oStV5ArfGqNV41cHV_AcVa2_Ojf50C2FPTMfKmvzjquhg9u6yj8eWEjVTSkY0Ne3fAoGXx20NWxXiIBqzPYBZlk___HH8Bo2ekaQ</recordid><startdate>1985</startdate><enddate>1985</enddate><creator>Guenounou, Moncef</creator><creator>Vacheron, Françoise</creator><creator>Nauciel, Charles</creator><creator>Agneray, Jean</creator><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1985</creationdate><title>Induction of interleukin 1 secretion by murine macrophages and human monocytes after stimulation by RU 41740, a bacterial immunomodulator</title><author>Guenounou, Moncef ; Vacheron, Françoise ; Nauciel, Charles ; Agneray, Jean</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-56dcb495bc0d6fff8ea09015d73acb571f5876ddaaff4c2ef1e371be5c607b033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Bacterial Proteins</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Female</topic><topic>Glycoproteins - pharmacology</topic><topic>Humans</topic><topic>Immunity, Cellular - drug effects</topic><topic>Immunomodulators</topic><topic>Interleukin-1 - metabolism</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Mice, Inbred DBA</topic><topic>Monocytes - drug effects</topic><topic>Monocytes - immunology</topic><topic>Pharmacology. Drug treatments</topic><topic>Stimulation, Chemical</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guenounou, Moncef</creatorcontrib><creatorcontrib>Vacheron, Françoise</creatorcontrib><creatorcontrib>Nauciel, Charles</creatorcontrib><creatorcontrib>Agneray, Jean</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guenounou, Moncef</au><au>Vacheron, Françoise</au><au>Nauciel, Charles</au><au>Agneray, Jean</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of interleukin 1 secretion by murine macrophages and human monocytes after stimulation by RU 41740, a bacterial immunomodulator</atitle><jtitle>International journal of immunopharmacology</jtitle><addtitle>Int J Immunopharmacol</addtitle><date>1985</date><risdate>1985</risdate><volume>7</volume><issue>2</issue><spage>287</spage><epage>290</epage><pages>287-290</pages><issn>0192-0561</issn><eissn>1879-3495</eissn><coden>IJIMDS</coden><abstract>RU 41740, a glycoprotein extract from
K. pneumoniae K
2O
1 strain, is an immunomodulating compound which has been shown to reduce infectious episodes in patients prone to recurrent infections. Data from preliminary experiments suggest that RU 41740 may affect several target cells, including T cells, B cells or macrophages. In the present report we show that RU 41740 can trigger mouse macrophages and human adherent mononuclear cells to produce interleukin 1 activity. Indeed, supernatants from mouse peritoneal adherent cells and human monocytes incubated in presence of RU 41740, can stimulate blastogenesis in thymocytes from C3H/HeJ mice. The data suggest that the immunomodulating effect of RU 41740 could be related to its ability to induce interleukin 1 production.</abstract><cop>Oxford</cop><pub>Elsevier Science</pub><pmid>3874176</pmid><doi>10.1016/0192-0561(85)90038-4</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0192-0561 |
| ispartof | International journal of immunopharmacology, 1985, Vol.7 (2), p.287-290 |
| issn | 0192-0561 1879-3495 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Bacterial Proteins Biological and medical sciences Cells, Cultured Female Glycoproteins - pharmacology Humans Immunity, Cellular - drug effects Immunomodulators Interleukin-1 - metabolism Macrophages - drug effects Macrophages - immunology Male Medical sciences Mice Mice, Inbred C3H Mice, Inbred DBA Monocytes - drug effects Monocytes - immunology Pharmacology. Drug treatments Stimulation, Chemical |
| title | Induction of interleukin 1 secretion by murine macrophages and human monocytes after stimulation by RU 41740, a bacterial immunomodulator |
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