Application of Monoclonal Antibodies in Basic Research, Diagnosis, and Therapy
Monoclonal antibodies are the natural products of hybrid cells called hybridomas, which are obtained from fusion of cultured myeloma cells with spleen cells from an immunized animal. Monoclonal antibodies can exhibit high specificity and affinity for distinct determinants (epitopes) in low-molecular...
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| Veröffentlicht in: | Journal of natural products (Print) 1985-03, Vol.48 (2), p.193-202 |
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| container_title | Journal of natural products (Print) |
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| creator | Abell, Creed W Denney, Richard M |
| description | Monoclonal antibodies are the natural products of hybrid cells called hybridomas, which are obtained from fusion of cultured myeloma cells with spleen cells from an immunized animal. Monoclonal antibodies can exhibit high specificity and affinity for distinct determinants (epitopes) in low-molecular-weight compounds and macromolecules. The availability of an inexhaustible and easily reproducible source of such antibodies, which can be harvested from cell culture supernatants of permanent hybrid cell lines and animal ascites fluids, promises to advance considerably our knowledge of biology at the cellular, subcellular, and molecular levels. In the future, hybridoma technology should allow preparation of many well-characterized diagnostic tools and development of novel therapeutic reagents. This presentation provides an overview of the rapidly growing areas in which monoclonal antibodies are being implemented. A few specific examples illustrate their value in advancing our knowledge of biomedical systems. |
| doi_str_mv | 10.1021/np50038a002 |
| format | Article |
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Nat. Prod</addtitle><description>Monoclonal antibodies are the natural products of hybrid cells called hybridomas, which are obtained from fusion of cultured myeloma cells with spleen cells from an immunized animal. Monoclonal antibodies can exhibit high specificity and affinity for distinct determinants (epitopes) in low-molecular-weight compounds and macromolecules. The availability of an inexhaustible and easily reproducible source of such antibodies, which can be harvested from cell culture supernatants of permanent hybrid cell lines and animal ascites fluids, promises to advance considerably our knowledge of biology at the cellular, subcellular, and molecular levels. In the future, hybridoma technology should allow preparation of many well-characterized diagnostic tools and development of novel therapeutic reagents. This presentation provides an overview of the rapidly growing areas in which monoclonal antibodies are being implemented. 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Economical aspects</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Molecular Weight</subject><subject>Monoamine Oxidase - metabolism</subject><subject>Multiple Myeloma - immunology</subject><subject>Other active biomolecules</subject><subject>Production of active biomolecules</subject><subject>Spleen - cytology</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0D1vFDEQBmALgcIRqKiRXKBQkAV_rHe95ZFwBCkBFI6Gxhp7vcRhz148exL593F0pxMFcjHFPHo1fgl5ydk7zgR_HyfFmNTAmHhEFlwJVjVMqMdkwXgjK6mb-il5hnjLCmOdOiJHUne8vAX5spymMTiYQ4o0DfQqxeTGFGGkyzgHm_rgkYZIPwAGR689esju5pSeB_gVEwY8pRB7ur7xGaa75-TJACP6F_t5TH6sPq7PLqrLr58-ny0vK6h5N1fWdW7o9FALz33bcA1CSyvaQXdNqyyXfW-dtl6ovnaNkMr2QkP5iO5qJa2Ux-Rklzvl9GfrcTabgM6PI0SftmhKZluzRhf4dgddTojZD2bKYQP5znBmHtoz_7RX9Kt97NZufH-w-7rK_vV-D-hgHDJEF_DAunJpo9vCqh0LOPu_hzXk36ZpZavM-tt3o66uf16c85VZFf9m58GhuU3bXOrH_x54D7gQkVU</recordid><startdate>198503</startdate><enddate>198503</enddate><creator>Abell, Creed W</creator><creator>Denney, Richard M</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198503</creationdate><title>Application of Monoclonal Antibodies in Basic Research, Diagnosis, and Therapy</title><author>Abell, Creed W ; Denney, Richard M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a419t-bc9cf98f42e1e7618a283b27f89675b13ddbc8be25d4c6235bd28a38689453b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Cells, Cultured</topic><topic>Chromatography, Affinity</topic><topic>Clone Cells - immunology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Health. Pharmaceutical industry</topic><topic>Hybridomas - immunology</topic><topic>Immunoenzyme Techniques</topic><topic>Industrial applications and implications. Economical aspects</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Molecular Weight</topic><topic>Monoamine Oxidase - metabolism</topic><topic>Multiple Myeloma - immunology</topic><topic>Other active biomolecules</topic><topic>Production of active biomolecules</topic><topic>Spleen - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abell, Creed W</creatorcontrib><creatorcontrib>Denney, Richard M</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Print)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abell, Creed W</au><au>Denney, Richard M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Application of Monoclonal Antibodies in Basic Research, Diagnosis, and Therapy</atitle><jtitle>Journal of natural products (Print)</jtitle><addtitle>J. Nat. Prod</addtitle><date>1985-03</date><risdate>1985</risdate><volume>48</volume><issue>2</issue><spage>193</spage><epage>202</epage><pages>193-202</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>Monoclonal antibodies are the natural products of hybrid cells called hybridomas, which are obtained from fusion of cultured myeloma cells with spleen cells from an immunized animal. Monoclonal antibodies can exhibit high specificity and affinity for distinct determinants (epitopes) in low-molecular-weight compounds and macromolecules. The availability of an inexhaustible and easily reproducible source of such antibodies, which can be harvested from cell culture supernatants of permanent hybrid cell lines and animal ascites fluids, promises to advance considerably our knowledge of biology at the cellular, subcellular, and molecular levels. 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| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Print), 1985-03, Vol.48 (2), p.193-202 |
| issn | 0163-3864 1520-6025 |
| language | eng |
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| source | ACS Publications; MEDLINE |
| subjects | Animals Antibodies, Monoclonal - therapeutic use Biological and medical sciences Biotechnology Cells, Cultured Chromatography, Affinity Clone Cells - immunology Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Hybridomas - immunology Immunoenzyme Techniques Industrial applications and implications. Economical aspects Mice Mice, Inbred BALB C Molecular Weight Monoamine Oxidase - metabolism Multiple Myeloma - immunology Other active biomolecules Production of active biomolecules Spleen - cytology |
| title | Application of Monoclonal Antibodies in Basic Research, Diagnosis, and Therapy |
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