A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11

We report the cloning of a gene, intronless in its coding region, which we have named APJ. This gene was cloned using the polymerase chain reaction (PCR), with a set of primers designed on the basis of the conservation that members of G protein-coupled receptors (GPCR) have in their transmembrane (T...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Gene 1993-12, Vol.136 (1), p.355-360
Hauptverfasser: O'Dowd, Brian F., Heiber, Michael, Chan, Audrey, Heng, Henry H.Q., Tsui, Lap-Chee, Kennedy, James L., Shi, Xiaomei, Petronis, Arturas, George, Susan R., Nguyen, Tuan
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 360
container_issue 1
container_start_page 355
container_title Gene
container_volume 136
creator O'Dowd, Brian F.
Heiber, Michael
Chan, Audrey
Heng, Henry H.Q.
Tsui, Lap-Chee
Kennedy, James L.
Shi, Xiaomei
Petronis, Arturas
George, Susan R.
Nguyen, Tuan
description We report the cloning of a gene, intronless in its coding region, which we have named APJ. This gene was cloned using the polymerase chain reaction (PCR), with a set of primers designed on the basis of the conservation that members of G protein-coupled receptors (GPCR) have in their transmembrane (TM) regions. The putative receptor protein, APJ, shares closest identity to the angiotensin receptor (AT1) ranging from 40 to 50% in the hydrophobic TM regions of these receptors. The transcripts for this gene were detected in many regions of the brain. PCR analysis of somatic cell lines found APJ-related sequences to be only present on chromosome 11, and high-resolution mapping by fluoresence in situ hybridization (FISH) sublocalized APJ on band q12.
doi_str_mv 10.1016/0378-1119(93)90495-O
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76173698</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>037811199390495O</els_id><sourcerecordid>16977578</sourcerecordid><originalsourceid>FETCH-LOGICAL-c468t-62d8e60fb8891bb8ef6e446df0d60285a98c439e8468c028929a6dafacfff7ef3</originalsourceid><addsrcrecordid>eNqFkUFvEzEQhS1EVULhH4DkA0Jw2GKvd732pVJVAa1UKRc4W449zhrt2sF2qPrv8SZRjuCLpXnfjGbeQ-gdJdeUUP6FsEE0lFL5SbLPknSyb9Yv0IqKQTaEMPESrc7IK_Q651-kvr5vL9GlaGVHWLtC0y0e97MOeAsBcBl1wXmMTxl7C6H48oyffBmrAEcCgonWh-2hosPWxwIh-4ATGNiVmLDPeIpGF7A4BmzGFOeY4wyY0jfowukpw9vTf4V-fvv64-6-eVx_f7i7fWxMx0VpeGsFcOI2Qki62QhwHLqOW0csJ63otRSmYxJEpU0tyFZqbrXTxjk3gGNX6ONx7i7F33vIRc0-G5gmHSDusxo4HRiX4r8g5XIY-mEBuyNoUsw5gVO75GednhUlaklDLVarxWolmTqkoda17f1p_n4zgz03neyv-oeTrrPRk0s6GJ_PGFtOO6x5c8SgmvbHQ1LZ-JoEWF9tL8pG_-89_gLW9Kcc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16977578</pqid></control><display><type>article</type><title>A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>O'Dowd, Brian F. ; Heiber, Michael ; Chan, Audrey ; Heng, Henry H.Q. ; Tsui, Lap-Chee ; Kennedy, James L. ; Shi, Xiaomei ; Petronis, Arturas ; George, Susan R. ; Nguyen, Tuan</creator><creatorcontrib>O'Dowd, Brian F. ; Heiber, Michael ; Chan, Audrey ; Heng, Henry H.Q. ; Tsui, Lap-Chee ; Kennedy, James L. ; Shi, Xiaomei ; Petronis, Arturas ; George, Susan R. ; Nguyen, Tuan</creatorcontrib><description>We report the cloning of a gene, intronless in its coding region, which we have named APJ. This gene was cloned using the polymerase chain reaction (PCR), with a set of primers designed on the basis of the conservation that members of G protein-coupled receptors (GPCR) have in their transmembrane (TM) regions. The putative receptor protein, APJ, shares closest identity to the angiotensin receptor (AT1) ranging from 40 to 50% in the hydrophobic TM regions of these receptors. The transcripts for this gene were detected in many regions of the brain. PCR analysis of somatic cell lines found APJ-related sequences to be only present on chromosome 11, and high-resolution mapping by fluoresence in situ hybridization (FISH) sublocalized APJ on band q12.</description><identifier>ISSN: 0378-1119</identifier><identifier>EISSN: 1879-0038</identifier><identifier>DOI: 10.1016/0378-1119(93)90495-O</identifier><identifier>PMID: 8294032</identifier><identifier>CODEN: GENED6</identifier><language>eng</language><publisher>Lausanne: Elsevier B.V</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; Biological and medical sciences ; Blotting, Northern ; Cell receptors ; Cell structures and functions ; Cells, Cultured ; Chromosome Mapping ; Chromosomes, Human, Pair 11 ; Cloning, Molecular ; DNA ; fluorescence in situ hybridization ; Fundamental and applied biological sciences. Psychology ; G protein-coupled receptors ; Genes. Genome ; Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors ; Humans ; In Situ Hybridization, Fluorescence ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; polymerase chain reaction ; Receptors, Angiotensin - genetics ; Sequence Homology, Amino Acid ; Species Specificity ; transmembrane ; vasopressin</subject><ispartof>Gene, 1993-12, Vol.136 (1), p.355-360</ispartof><rights>1993</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-62d8e60fb8891bb8ef6e446df0d60285a98c439e8468c028929a6dafacfff7ef3</citedby><cites>FETCH-LOGICAL-c468t-62d8e60fb8891bb8ef6e446df0d60285a98c439e8468c028929a6dafacfff7ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0378-1119(93)90495-O$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=3892998$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8294032$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Dowd, Brian F.</creatorcontrib><creatorcontrib>Heiber, Michael</creatorcontrib><creatorcontrib>Chan, Audrey</creatorcontrib><creatorcontrib>Heng, Henry H.Q.</creatorcontrib><creatorcontrib>Tsui, Lap-Chee</creatorcontrib><creatorcontrib>Kennedy, James L.</creatorcontrib><creatorcontrib>Shi, Xiaomei</creatorcontrib><creatorcontrib>Petronis, Arturas</creatorcontrib><creatorcontrib>George, Susan R.</creatorcontrib><creatorcontrib>Nguyen, Tuan</creatorcontrib><title>A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11</title><title>Gene</title><addtitle>Gene</addtitle><description>We report the cloning of a gene, intronless in its coding region, which we have named APJ. This gene was cloned using the polymerase chain reaction (PCR), with a set of primers designed on the basis of the conservation that members of G protein-coupled receptors (GPCR) have in their transmembrane (TM) regions. The putative receptor protein, APJ, shares closest identity to the angiotensin receptor (AT1) ranging from 40 to 50% in the hydrophobic TM regions of these receptors. The transcripts for this gene were detected in many regions of the brain. PCR analysis of somatic cell lines found APJ-related sequences to be only present on chromosome 11, and high-resolution mapping by fluoresence in situ hybridization (FISH) sublocalized APJ on band q12.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Cells, Cultured</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 11</subject><subject>Cloning, Molecular</subject><subject>DNA</subject><subject>fluorescence in situ hybridization</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>G protein-coupled receptors</subject><subject>Genes. Genome</subject><subject>Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>polymerase chain reaction</subject><subject>Receptors, Angiotensin - genetics</subject><subject>Sequence Homology, Amino Acid</subject><subject>Species Specificity</subject><subject>transmembrane</subject><subject>vasopressin</subject><issn>0378-1119</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvEzEQhS1EVULhH4DkA0Jw2GKvd732pVJVAa1UKRc4W449zhrt2sF2qPrv8SZRjuCLpXnfjGbeQ-gdJdeUUP6FsEE0lFL5SbLPknSyb9Yv0IqKQTaEMPESrc7IK_Q651-kvr5vL9GlaGVHWLtC0y0e97MOeAsBcBl1wXmMTxl7C6H48oyffBmrAEcCgonWh-2hosPWxwIh-4ATGNiVmLDPeIpGF7A4BmzGFOeY4wyY0jfowukpw9vTf4V-fvv64-6-eVx_f7i7fWxMx0VpeGsFcOI2Qki62QhwHLqOW0csJ63otRSmYxJEpU0tyFZqbrXTxjk3gGNX6ONx7i7F33vIRc0-G5gmHSDusxo4HRiX4r8g5XIY-mEBuyNoUsw5gVO75GednhUlaklDLVarxWolmTqkoda17f1p_n4zgz03neyv-oeTrrPRk0s6GJ_PGFtOO6x5c8SgmvbHQ1LZ-JoEWF9tL8pG_-89_gLW9Kcc</recordid><startdate>19931222</startdate><enddate>19931222</enddate><creator>O'Dowd, Brian F.</creator><creator>Heiber, Michael</creator><creator>Chan, Audrey</creator><creator>Heng, Henry H.Q.</creator><creator>Tsui, Lap-Chee</creator><creator>Kennedy, James L.</creator><creator>Shi, Xiaomei</creator><creator>Petronis, Arturas</creator><creator>George, Susan R.</creator><creator>Nguyen, Tuan</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19931222</creationdate><title>A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11</title><author>O'Dowd, Brian F. ; Heiber, Michael ; Chan, Audrey ; Heng, Henry H.Q. ; Tsui, Lap-Chee ; Kennedy, James L. ; Shi, Xiaomei ; Petronis, Arturas ; George, Susan R. ; Nguyen, Tuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-62d8e60fb8891bb8ef6e446df0d60285a98c439e8468c028929a6dafacfff7ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>Cells, Cultured</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 11</topic><topic>Cloning, Molecular</topic><topic>DNA</topic><topic>fluorescence in situ hybridization</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>G protein-coupled receptors</topic><topic>Genes. Genome</topic><topic>Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>polymerase chain reaction</topic><topic>Receptors, Angiotensin - genetics</topic><topic>Sequence Homology, Amino Acid</topic><topic>Species Specificity</topic><topic>transmembrane</topic><topic>vasopressin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Dowd, Brian F.</creatorcontrib><creatorcontrib>Heiber, Michael</creatorcontrib><creatorcontrib>Chan, Audrey</creatorcontrib><creatorcontrib>Heng, Henry H.Q.</creatorcontrib><creatorcontrib>Tsui, Lap-Chee</creatorcontrib><creatorcontrib>Kennedy, James L.</creatorcontrib><creatorcontrib>Shi, Xiaomei</creatorcontrib><creatorcontrib>Petronis, Arturas</creatorcontrib><creatorcontrib>George, Susan R.</creatorcontrib><creatorcontrib>Nguyen, Tuan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Dowd, Brian F.</au><au>Heiber, Michael</au><au>Chan, Audrey</au><au>Heng, Henry H.Q.</au><au>Tsui, Lap-Chee</au><au>Kennedy, James L.</au><au>Shi, Xiaomei</au><au>Petronis, Arturas</au><au>George, Susan R.</au><au>Nguyen, Tuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11</atitle><jtitle>Gene</jtitle><addtitle>Gene</addtitle><date>1993-12-22</date><risdate>1993</risdate><volume>136</volume><issue>1</issue><spage>355</spage><epage>360</epage><pages>355-360</pages><issn>0378-1119</issn><eissn>1879-0038</eissn><coden>GENED6</coden><abstract>We report the cloning of a gene, intronless in its coding region, which we have named APJ. This gene was cloned using the polymerase chain reaction (PCR), with a set of primers designed on the basis of the conservation that members of G protein-coupled receptors (GPCR) have in their transmembrane (TM) regions. The putative receptor protein, APJ, shares closest identity to the angiotensin receptor (AT1) ranging from 40 to 50% in the hydrophobic TM regions of these receptors. The transcripts for this gene were detected in many regions of the brain. PCR analysis of somatic cell lines found APJ-related sequences to be only present on chromosome 11, and high-resolution mapping by fluoresence in situ hybridization (FISH) sublocalized APJ on band q12.</abstract><cop>Lausanne</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>8294032</pmid><doi>10.1016/0378-1119(93)90495-O</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0378-1119
ispartof Gene, 1993-12, Vol.136 (1), p.355-360
issn 0378-1119
1879-0038
language eng
recordid cdi_proquest_miscellaneous_76173698
source MEDLINE; Access via ScienceDirect (Elsevier)
subjects Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
Blotting, Northern
Cell receptors
Cell structures and functions
Cells, Cultured
Chromosome Mapping
Chromosomes, Human, Pair 11
Cloning, Molecular
DNA
fluorescence in situ hybridization
Fundamental and applied biological sciences. Psychology
G protein-coupled receptors
Genes. Genome
Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors
Humans
In Situ Hybridization, Fluorescence
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
polymerase chain reaction
Receptors, Angiotensin - genetics
Sequence Homology, Amino Acid
Species Specificity
transmembrane
vasopressin
title A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T19%3A36%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20human%20gene%20that%20shows%20identity%20with%20the%20gene%20encoding%20the%20angiotensin%20receptor%20is%20located%20on%20chromosome%2011&rft.jtitle=Gene&rft.au=O'Dowd,%20Brian%20F.&rft.date=1993-12-22&rft.volume=136&rft.issue=1&rft.spage=355&rft.epage=360&rft.pages=355-360&rft.issn=0378-1119&rft.eissn=1879-0038&rft.coden=GENED6&rft_id=info:doi/10.1016/0378-1119(93)90495-O&rft_dat=%3Cproquest_cross%3E16977578%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16977578&rft_id=info:pmid/8294032&rft_els_id=037811199390495O&rfr_iscdi=true