A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11
We report the cloning of a gene, intronless in its coding region, which we have named APJ. This gene was cloned using the polymerase chain reaction (PCR), with a set of primers designed on the basis of the conservation that members of G protein-coupled receptors (GPCR) have in their transmembrane (T...
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Veröffentlicht in: | Gene 1993-12, Vol.136 (1), p.355-360 |
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container_title | Gene |
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creator | O'Dowd, Brian F. Heiber, Michael Chan, Audrey Heng, Henry H.Q. Tsui, Lap-Chee Kennedy, James L. Shi, Xiaomei Petronis, Arturas George, Susan R. Nguyen, Tuan |
description | We report the cloning of a gene, intronless in its coding region, which we have named
APJ. This gene was cloned using the polymerase chain reaction (PCR), with a set of primers designed on the basis of the conservation that members of G protein-coupled receptors (GPCR) have in their transmembrane (TM) regions. The putative receptor protein, APJ, shares closest identity to the angiotensin receptor (AT1) ranging from 40 to 50% in the hydrophobic TM regions of these receptors. The transcripts for this gene were detected in many regions of the brain. PCR analysis of somatic cell lines found APJ-related sequences to be only present on chromosome 11, and high-resolution mapping by fluoresence in situ hybridization (FISH) sublocalized
APJ on band q12. |
doi_str_mv | 10.1016/0378-1119(93)90495-O |
format | Article |
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APJ. This gene was cloned using the polymerase chain reaction (PCR), with a set of primers designed on the basis of the conservation that members of G protein-coupled receptors (GPCR) have in their transmembrane (TM) regions. The putative receptor protein, APJ, shares closest identity to the angiotensin receptor (AT1) ranging from 40 to 50% in the hydrophobic TM regions of these receptors. The transcripts for this gene were detected in many regions of the brain. PCR analysis of somatic cell lines found APJ-related sequences to be only present on chromosome 11, and high-resolution mapping by fluoresence in situ hybridization (FISH) sublocalized
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APJ. This gene was cloned using the polymerase chain reaction (PCR), with a set of primers designed on the basis of the conservation that members of G protein-coupled receptors (GPCR) have in their transmembrane (TM) regions. The putative receptor protein, APJ, shares closest identity to the angiotensin receptor (AT1) ranging from 40 to 50% in the hydrophobic TM regions of these receptors. The transcripts for this gene were detected in many regions of the brain. PCR analysis of somatic cell lines found APJ-related sequences to be only present on chromosome 11, and high-resolution mapping by fluoresence in situ hybridization (FISH) sublocalized
APJ on band q12.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Cells, Cultured</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 11</subject><subject>Cloning, Molecular</subject><subject>DNA</subject><subject>fluorescence in situ hybridization</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>G protein-coupled receptors</subject><subject>Genes. Genome</subject><subject>Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>polymerase chain reaction</subject><subject>Receptors, Angiotensin - genetics</subject><subject>Sequence Homology, Amino Acid</subject><subject>Species Specificity</subject><subject>transmembrane</subject><subject>vasopressin</subject><issn>0378-1119</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvEzEQhS1EVULhH4DkA0Jw2GKvd732pVJVAa1UKRc4W449zhrt2sF2qPrv8SZRjuCLpXnfjGbeQ-gdJdeUUP6FsEE0lFL5SbLPknSyb9Yv0IqKQTaEMPESrc7IK_Q651-kvr5vL9GlaGVHWLtC0y0e97MOeAsBcBl1wXmMTxl7C6H48oyffBmrAEcCgonWh-2hosPWxwIh-4ATGNiVmLDPeIpGF7A4BmzGFOeY4wyY0jfowukpw9vTf4V-fvv64-6-eVx_f7i7fWxMx0VpeGsFcOI2Qki62QhwHLqOW0csJ63otRSmYxJEpU0tyFZqbrXTxjk3gGNX6ONx7i7F33vIRc0-G5gmHSDusxo4HRiX4r8g5XIY-mEBuyNoUsw5gVO75GednhUlaklDLVarxWolmTqkoda17f1p_n4zgz03neyv-oeTrrPRk0s6GJ_PGFtOO6x5c8SgmvbHQ1LZ-JoEWF9tL8pG_-89_gLW9Kcc</recordid><startdate>19931222</startdate><enddate>19931222</enddate><creator>O'Dowd, Brian F.</creator><creator>Heiber, Michael</creator><creator>Chan, Audrey</creator><creator>Heng, Henry H.Q.</creator><creator>Tsui, Lap-Chee</creator><creator>Kennedy, James L.</creator><creator>Shi, Xiaomei</creator><creator>Petronis, Arturas</creator><creator>George, Susan R.</creator><creator>Nguyen, Tuan</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19931222</creationdate><title>A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11</title><author>O'Dowd, Brian F. ; Heiber, Michael ; Chan, Audrey ; Heng, Henry H.Q. ; Tsui, Lap-Chee ; Kennedy, James L. ; Shi, Xiaomei ; Petronis, Arturas ; George, Susan R. ; Nguyen, Tuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-62d8e60fb8891bb8ef6e446df0d60285a98c439e8468c028929a6dafacfff7ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>Cells, Cultured</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 11</topic><topic>Cloning, Molecular</topic><topic>DNA</topic><topic>fluorescence in situ hybridization</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>G protein-coupled receptors</topic><topic>Genes. Genome</topic><topic>Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>polymerase chain reaction</topic><topic>Receptors, Angiotensin - genetics</topic><topic>Sequence Homology, Amino Acid</topic><topic>Species Specificity</topic><topic>transmembrane</topic><topic>vasopressin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Dowd, Brian F.</creatorcontrib><creatorcontrib>Heiber, Michael</creatorcontrib><creatorcontrib>Chan, Audrey</creatorcontrib><creatorcontrib>Heng, Henry H.Q.</creatorcontrib><creatorcontrib>Tsui, Lap-Chee</creatorcontrib><creatorcontrib>Kennedy, James L.</creatorcontrib><creatorcontrib>Shi, Xiaomei</creatorcontrib><creatorcontrib>Petronis, Arturas</creatorcontrib><creatorcontrib>George, Susan R.</creatorcontrib><creatorcontrib>Nguyen, Tuan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Dowd, Brian F.</au><au>Heiber, Michael</au><au>Chan, Audrey</au><au>Heng, Henry H.Q.</au><au>Tsui, Lap-Chee</au><au>Kennedy, James L.</au><au>Shi, Xiaomei</au><au>Petronis, Arturas</au><au>George, Susan R.</au><au>Nguyen, Tuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11</atitle><jtitle>Gene</jtitle><addtitle>Gene</addtitle><date>1993-12-22</date><risdate>1993</risdate><volume>136</volume><issue>1</issue><spage>355</spage><epage>360</epage><pages>355-360</pages><issn>0378-1119</issn><eissn>1879-0038</eissn><coden>GENED6</coden><abstract>We report the cloning of a gene, intronless in its coding region, which we have named
APJ. This gene was cloned using the polymerase chain reaction (PCR), with a set of primers designed on the basis of the conservation that members of G protein-coupled receptors (GPCR) have in their transmembrane (TM) regions. The putative receptor protein, APJ, shares closest identity to the angiotensin receptor (AT1) ranging from 40 to 50% in the hydrophobic TM regions of these receptors. The transcripts for this gene were detected in many regions of the brain. PCR analysis of somatic cell lines found APJ-related sequences to be only present on chromosome 11, and high-resolution mapping by fluoresence in situ hybridization (FISH) sublocalized
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subjects | Amino Acid Sequence Animals Base Sequence Biological and medical sciences Blotting, Northern Cell receptors Cell structures and functions Cells, Cultured Chromosome Mapping Chromosomes, Human, Pair 11 Cloning, Molecular DNA fluorescence in situ hybridization Fundamental and applied biological sciences. Psychology G protein-coupled receptors Genes. Genome Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Humans In Situ Hybridization, Fluorescence Molecular and cellular biology Molecular genetics Molecular Sequence Data polymerase chain reaction Receptors, Angiotensin - genetics Sequence Homology, Amino Acid Species Specificity transmembrane vasopressin |
title | A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11 |
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