Pharmacokinetic Analysis of Phenytoin and Its Derivatives in Plasma and Brain in Rats

The derivatives of phenytoin (DPH) were synthesized by the reaction at 3 position of hydantoin ring with valproic acid and valeric acid, producing valproyl DPH (VPDPH) and valeroyl DPH (VADPH), respectively. These derivatives showed much higher lipid solubilities than that of DPH. Their distribution...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1993/10/15, Vol.16(10), pp.1025-1030
Hauptverfasser:	OGISO, Taro, IWAKI, Masahiro, TANINO, Tadatoshi, MURAOKA, Osamu, TANABE, Genzou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Brain - metabolism brain distribution Injections, Intravenous Male Medical sciences Models, Biological modified 2-compartment model Neuropharmacology pharmacokinetic analysis Pharmacology. Drug treatments Phenytoin - analogs & derivatives Phenytoin - chemical synthesis Phenytoin - pharmacokinetics Rats Rats, Wistar valeroyl phenytoin valpropyl phenytoin
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