Cloning, expression and characterisation of the cDNA encoding human hepatic squalene synthase, and its relationship to phytoene synthase

The reaction catalysed by squalene synthase (SQS) shows many similarities to that performed by another polyisoprene synthase, phytoene synthase (PhS). By identifying sequences conserved between yeast SQS (ySQS) and PhS, we have cloned a 2-kb cDNA ( hSQS) encoding human SQS, a protein of 417 amino ac...

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Veröffentlicht in:	Gene 1993-12, Vol.136 (1), p.185-192
Hauptverfasser:	Summers, Claire, Karst, Francis, Charles, Andrew D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkyl and Aryl Transferases Amino Acid Sequence Animals Base Sequence Biological and medical sciences biosynthesis Cell Line cholesterol Cloning, Molecular DNA, Complementary Escherichia coli Farnesyl-Diphosphate Farnesyltransferase - genetics Fundamental and applied biological sciences. Psychology Genes. Genome Geranylgeranyl-Diphosphate Geranylgeranyltransferase Humans Liver - enzymology lovastatin Molecular and cellular biology Molecular genetics Molecular Sequence Data PCR Polymerase Chain Reaction Rats recombinant DNA Recombinant Proteins - genetics Sequence Analysis, DNA Sequence Homology, Amino Acid Transcription, Genetic transcriptional regulation Transferases - genetics Yeast
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