Action of 2-β- d-ribofuranosylthiazole-4-carboxamide (tiazofurin) against untreated human ovarian cancers in the murine xenograft assay

The activity of 2-β- d-ribofuranosylthiazole-4-carboxamide (tiazofurin) was determined in nine untreated human ovarian cancer specimens, using the murine subrenal capsule xenograft assay. Tumor cytotoxic effect was demonstrated in seven out of the nine tumors implanted. The drug was well tolerated b...

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Veröffentlicht in:	Gynecologic oncology 1985-07, Vol.21 (3), p.351-355
Hauptverfasser:	Micha, John Paul, Kucera, Paul R., Preve, Carlo U., Rettenmaier, Mark A., Stratton, Joan A., DiSaia, Philip J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Female Mice Mice, Inbred Strains Neoplasm Transplantation Ovarian Neoplasms - drug therapy Ribavirin - analogs & derivatives Ribavirin - therapeutic use Ribonucleosides - therapeutic use
Online-Zugang:	Volltext
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