Lack of variation in the nucleotide sequence corresponding to the transmembrane domain of the β-amyloid precursor protein in Alzheimer's disease

The nucleotide sequence corresponding to the APP transmembrane domain and flanking regions of charged amino acids was determined for 91 patients with histologically confirmed Alzheimer's disease, 9 patients with dementias of other etiologies, and 14 controls who had no identifiable brain diseas...

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Veröffentlicht in:	American journal of medical genetics 1993-10, Vol.48 (3), p.131-136
Hauptverfasser:	Zubenko, George S., Stiffler, Scott, Farr, Joan, Kopp, Ursula, Hughes, Hugh, Kaplan, Barry B., Moossy, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer's disease Amino Acid Sequence Amyloid beta-Protein Precursor - chemistry Base Sequence Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Genetic Testing Genetic Variation genetics Medical sciences Membrane Proteins - genetics Molecular Sequence Data Mutation mutations Neurology Protein Structure, Tertiary β-amyloid precursor protein
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