Detection of activated platelets in urinary sediments by immunofluorescence using monoclonal antibody to human platelet GMP-140 in patients with IgA nephropathy
The presence of activated platelets in the urinary sediments was studied by indirect immunofluorescence using monoclonal antigranular membrane protein (GMP)‐140 antibody. GMP‐140 is generally expressed on the activated‐platelets and ‐vascular endothelial cells. The purpose of the present study was t...
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| Veröffentlicht in: | Journal of clinical laboratory analysis 1993, Vol.7 (6), p.329-333 |
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| container_title | Journal of clinical laboratory analysis |
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| creator | Tomino, Yasuhiko Tsushima, Yoshimi Ohmuro, Hiroyuki Shimizu, Masahiko Kuramoto, Takao Shirato, Isao Koide, Hikaru |
| description | The presence of activated platelets in the urinary sediments was studied by indirect immunofluorescence using monoclonal antigranular membrane protein (GMP)‐140 antibody. GMP‐140 is generally expressed on the activated‐platelets and ‐vascular endothelial cells. The purpose of the present study was to determine if the presence of activated platelets in the urinary sediments is correlated with glomerular injuries in patients with IgA nephropathy. Fourteen patients with IgA nephropathy and 11 patients with diffuse mesangial proliferative glomerulonephritis without glomerular IgA deposition (PGN) were examined. The number of activated platelets in the urinary sediments was markedly increased in patients in the advanced stage of IgA nephropathy. The ratio of activated platelets to total platelets in the urinary sediments was also increased in such patients. It appears that the detection of activated platelets in the urinary sediments is useful in determining the degree of histological changes in IgA nephropathy. © 1993 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jcla.1860070606 |
| format | Article |
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GMP‐140 is generally expressed on the activated‐platelets and ‐vascular endothelial cells. The purpose of the present study was to determine if the presence of activated platelets in the urinary sediments is correlated with glomerular injuries in patients with IgA nephropathy. Fourteen patients with IgA nephropathy and 11 patients with diffuse mesangial proliferative glomerulonephritis without glomerular IgA deposition (PGN) were examined. The number of activated platelets in the urinary sediments was markedly increased in patients in the advanced stage of IgA nephropathy. The ratio of activated platelets to total platelets in the urinary sediments was also increased in such patients. It appears that the detection of activated platelets in the urinary sediments is useful in determining the degree of histological changes in IgA nephropathy. © 1993 Wiley‐Liss, Inc.</description><identifier>ISSN: 0887-8013</identifier><identifier>EISSN: 1098-2825</identifier><identifier>DOI: 10.1002/jcla.1860070606</identifier><identifier>PMID: 7506303</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>activated platelets ; Adult ; Antibodies, Monoclonal ; Capillaries - pathology ; Fluorescent Antibody Technique ; glomerular injuries ; Glomerulonephritis, IGA - blood ; Glomerulonephritis, IGA - urine ; Glomerulonephritis, Membranoproliferative - blood ; Glomerulonephritis, Membranoproliferative - urine ; Humans ; Kidney Glomerulus - blood supply ; P-Selectin ; Platelet Activation ; Platelet Membrane Glycoproteins - immunology ; Platelet Membrane Glycoproteins - urine ; urine</subject><ispartof>Journal of clinical laboratory analysis, 1993, Vol.7 (6), p.329-333</ispartof><rights>Copyright © 1993 Wiley Periodicals, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3826-f167470147e8aefdf6e637931b33f2589df0935a305d8e2c302b01b3cba87ac53</citedby><cites>FETCH-LOGICAL-c3826-f167470147e8aefdf6e637931b33f2589df0935a305d8e2c302b01b3cba87ac53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcla.1860070606$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcla.1860070606$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7506303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tomino, Yasuhiko</creatorcontrib><creatorcontrib>Tsushima, Yoshimi</creatorcontrib><creatorcontrib>Ohmuro, Hiroyuki</creatorcontrib><creatorcontrib>Shimizu, Masahiko</creatorcontrib><creatorcontrib>Kuramoto, Takao</creatorcontrib><creatorcontrib>Shirato, Isao</creatorcontrib><creatorcontrib>Koide, Hikaru</creatorcontrib><title>Detection of activated platelets in urinary sediments by immunofluorescence using monoclonal antibody to human platelet GMP-140 in patients with IgA nephropathy</title><title>Journal of clinical laboratory analysis</title><addtitle>J. Clin. Lab. Anal</addtitle><description>The presence of activated platelets in the urinary sediments was studied by indirect immunofluorescence using monoclonal antigranular membrane protein (GMP)‐140 antibody. GMP‐140 is generally expressed on the activated‐platelets and ‐vascular endothelial cells. The purpose of the present study was to determine if the presence of activated platelets in the urinary sediments is correlated with glomerular injuries in patients with IgA nephropathy. Fourteen patients with IgA nephropathy and 11 patients with diffuse mesangial proliferative glomerulonephritis without glomerular IgA deposition (PGN) were examined. The number of activated platelets in the urinary sediments was markedly increased in patients in the advanced stage of IgA nephropathy. The ratio of activated platelets to total platelets in the urinary sediments was also increased in such patients. It appears that the detection of activated platelets in the urinary sediments is useful in determining the degree of histological changes in IgA nephropathy. © 1993 Wiley‐Liss, Inc.</description><subject>activated platelets</subject><subject>Adult</subject><subject>Antibodies, Monoclonal</subject><subject>Capillaries - pathology</subject><subject>Fluorescent Antibody Technique</subject><subject>glomerular injuries</subject><subject>Glomerulonephritis, IGA - blood</subject><subject>Glomerulonephritis, IGA - urine</subject><subject>Glomerulonephritis, Membranoproliferative - blood</subject><subject>Glomerulonephritis, Membranoproliferative - urine</subject><subject>Humans</subject><subject>Kidney Glomerulus - blood supply</subject><subject>P-Selectin</subject><subject>Platelet Activation</subject><subject>Platelet Membrane Glycoproteins - immunology</subject><subject>Platelet Membrane Glycoproteins - urine</subject><subject>urine</subject><issn>0887-8013</issn><issn>1098-2825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS0EKkvhzAnJJ25px_HGdsRp2UIoWv4IiipxsZxk0nVx7BAnlHwbPipZdrWIE6ex5r33k8aPkKcMzhhAen5bOXPGlACQIEDcIwsGuUpSlWb3yQKUkokCxh-SRzHeAoDKmTghJzIDwYEvyK8LHLAabPA0NNTMrx9mwJp2bh4Oh0itp2NvveknGrG2Lfp5WU7Utu3oQ-PG0GOs0FdIx2j9DW2DD5UL3jhq_GDLUE90CHQ7tsYfubR49zFhS9jhOzPYP9Q7O2zp5c2Keuy2fZj32-kxedAYF_HJYZ6SL69fXa3fJJsPxeV6tUkqrlKRNEzIpQS2lKgMNnUjUHCZc1Zy3qSZyusGcp4ZDlmtMK04pCXMYlUaJU2V8VPyfM_t-vB9xDjo1s5nOWc8hjFqKZjgIl_OxvO9sepDjD02uuttO3-PZqB3nehdJ_pvJ3Pi2QE9li3WR_-hhFl_sdfvrMPpfzj9dr1Z_UNP9mkbB_x5TJv-mxaSy0xfvy_01afi89frQuqX_Dc4KavH</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Tomino, Yasuhiko</creator><creator>Tsushima, Yoshimi</creator><creator>Ohmuro, Hiroyuki</creator><creator>Shimizu, Masahiko</creator><creator>Kuramoto, Takao</creator><creator>Shirato, Isao</creator><creator>Koide, Hikaru</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>Detection of activated platelets in urinary sediments by immunofluorescence using monoclonal antibody to human platelet GMP-140 in patients with IgA nephropathy</title><author>Tomino, Yasuhiko ; Tsushima, Yoshimi ; Ohmuro, Hiroyuki ; Shimizu, Masahiko ; Kuramoto, Takao ; Shirato, Isao ; Koide, Hikaru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3826-f167470147e8aefdf6e637931b33f2589df0935a305d8e2c302b01b3cba87ac53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>activated platelets</topic><topic>Adult</topic><topic>Antibodies, Monoclonal</topic><topic>Capillaries - pathology</topic><topic>Fluorescent Antibody Technique</topic><topic>glomerular injuries</topic><topic>Glomerulonephritis, IGA - blood</topic><topic>Glomerulonephritis, IGA - urine</topic><topic>Glomerulonephritis, Membranoproliferative - blood</topic><topic>Glomerulonephritis, Membranoproliferative - urine</topic><topic>Humans</topic><topic>Kidney Glomerulus - blood supply</topic><topic>P-Selectin</topic><topic>Platelet Activation</topic><topic>Platelet Membrane Glycoproteins - immunology</topic><topic>Platelet Membrane Glycoproteins - urine</topic><topic>urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tomino, Yasuhiko</creatorcontrib><creatorcontrib>Tsushima, Yoshimi</creatorcontrib><creatorcontrib>Ohmuro, Hiroyuki</creatorcontrib><creatorcontrib>Shimizu, Masahiko</creatorcontrib><creatorcontrib>Kuramoto, Takao</creatorcontrib><creatorcontrib>Shirato, Isao</creatorcontrib><creatorcontrib>Koide, Hikaru</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical laboratory analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tomino, Yasuhiko</au><au>Tsushima, Yoshimi</au><au>Ohmuro, Hiroyuki</au><au>Shimizu, Masahiko</au><au>Kuramoto, Takao</au><au>Shirato, Isao</au><au>Koide, Hikaru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of activated platelets in urinary sediments by immunofluorescence using monoclonal antibody to human platelet GMP-140 in patients with IgA nephropathy</atitle><jtitle>Journal of clinical laboratory analysis</jtitle><addtitle>J. Clin. Lab. Anal</addtitle><date>1993</date><risdate>1993</risdate><volume>7</volume><issue>6</issue><spage>329</spage><epage>333</epage><pages>329-333</pages><issn>0887-8013</issn><eissn>1098-2825</eissn><abstract>The presence of activated platelets in the urinary sediments was studied by indirect immunofluorescence using monoclonal antigranular membrane protein (GMP)‐140 antibody. GMP‐140 is generally expressed on the activated‐platelets and ‐vascular endothelial cells. The purpose of the present study was to determine if the presence of activated platelets in the urinary sediments is correlated with glomerular injuries in patients with IgA nephropathy. Fourteen patients with IgA nephropathy and 11 patients with diffuse mesangial proliferative glomerulonephritis without glomerular IgA deposition (PGN) were examined. The number of activated platelets in the urinary sediments was markedly increased in patients in the advanced stage of IgA nephropathy. The ratio of activated platelets to total platelets in the urinary sediments was also increased in such patients. It appears that the detection of activated platelets in the urinary sediments is useful in determining the degree of histological changes in IgA nephropathy. © 1993 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>7506303</pmid><doi>10.1002/jcla.1860070606</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of clinical laboratory analysis, 1993, Vol.7 (6), p.329-333 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | activated platelets Adult Antibodies, Monoclonal Capillaries - pathology Fluorescent Antibody Technique glomerular injuries Glomerulonephritis, IGA - blood Glomerulonephritis, IGA - urine Glomerulonephritis, Membranoproliferative - blood Glomerulonephritis, Membranoproliferative - urine Humans Kidney Glomerulus - blood supply P-Selectin Platelet Activation Platelet Membrane Glycoproteins - immunology Platelet Membrane Glycoproteins - urine urine |
| title | Detection of activated platelets in urinary sediments by immunofluorescence using monoclonal antibody to human platelet GMP-140 in patients with IgA nephropathy |
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