Antibodies to skeletal muscle in myasthenia gravis: Part 2. Prevalence in non-thymoma patients
Anti-skeletal muscle antibodies (AMA) were measured in 340 non-thymoma patients with myasthenia gravis (MG) by both an ELISA with citric acid muscle extract and by immunofluorescence assay. Three a-AChR negative but AMA-positive patients were found. The occurrence of AMA was related to the age at on...
Gespeichert in:
| Veröffentlicht in: | Journal of the neurological sciences 1993-12, Vol.120 (1), p.78-81 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 81 |
|---|---|
| container_issue | 1 |
| container_start_page | 78 |
| container_title | Journal of the neurological sciences |
| container_volume | 120 |
| creator | Kuks, J.B.M. Limburg, P.C. Horst, G. Oosterhuis, H.J.G.H. |
| description | Anti-skeletal muscle antibodies (AMA) were measured in 340 non-thymoma patients with myasthenia gravis (MG) by both an ELISA with citric acid muscle extract and by immunofluorescence assay. Three a-AChR negative but AMA-positive patients were found. The occurrence of AMA was related to the age at onset in patients with an onset of MG beyond 40 years and with duration of disease in patients with an earlier onset of MG. This stresses the heterogeneity of late onset and early onset MG. Serial measurements in individual patients revealed no evidence for a thymic role in the generation of AMA. There was no difference in specificity of AMA in early and late onset patients. The presence of AMA in CT-negative patients is not necessarily suggestive of a radiological shortcoming in the detection of thymoma since in 16 AMA-positive patients from our series no thymoma was found at operation or obduction. |
| doi_str_mv | 10.1016/0022-510X(93)90028-W |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_76163467</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0022510X9390028W</els_id><sourcerecordid>76163467</sourcerecordid><originalsourceid>FETCH-LOGICAL-e176t-da116f289c44c91985f4d7f1b5c7ee4a1e41dd556b0095b5565cd2913577bd8d3</originalsourceid><addsrcrecordid>eNo9kU1LAzEQhoMotVb_gUJOoofVZHezm3gQSvELCvag1JMhm0xtdD9qki3037vbFk8zw_swzLwvQueU3FBCs1tC4jhilHxcieRadBOP5gdoSHnOI8Z5coiG_8gxOvH-mxCScS4GaMBjLgiPh-hzXAdbNMaCx6HB_gdKCKrEVet1CdjWuNooH5ZQW4W_nFpbf4dnygUc3-CZg7UqodZbsG7qKCw3VVMpvFLBQh38KTpaqNLD2b6O0Pvjw9vkOZq-Pr1MxtMIaJ6FyChKs0V3k05TLajgbJGafEELpnOAVFFIqTGMZQUhghVdw7SJBU1YnheGm2SELnd7V675bcEHWVmvoSxVDU3rZZ7RLEmzvAMv9mBbVGDkytlKuY3cG9Lp9zsdumvXFpz02vYfGutAB2kaKymRfQCyd1f27kqRyG0Acp78AcKVd6c</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76163467</pqid></control><display><type>article</type><title>Antibodies to skeletal muscle in myasthenia gravis: Part 2. Prevalence in non-thymoma patients</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Kuks, J.B.M. ; Limburg, P.C. ; Horst, G. ; Oosterhuis, H.J.G.H.</creator><creatorcontrib>Kuks, J.B.M. ; Limburg, P.C. ; Horst, G. ; Oosterhuis, H.J.G.H.</creatorcontrib><description>Anti-skeletal muscle antibodies (AMA) were measured in 340 non-thymoma patients with myasthenia gravis (MG) by both an ELISA with citric acid muscle extract and by immunofluorescence assay. Three a-AChR negative but AMA-positive patients were found. The occurrence of AMA was related to the age at onset in patients with an onset of MG beyond 40 years and with duration of disease in patients with an earlier onset of MG. This stresses the heterogeneity of late onset and early onset MG. Serial measurements in individual patients revealed no evidence for a thymic role in the generation of AMA. There was no difference in specificity of AMA in early and late onset patients. The presence of AMA in CT-negative patients is not necessarily suggestive of a radiological shortcoming in the detection of thymoma since in 16 AMA-positive patients from our series no thymoma was found at operation or obduction.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/0022-510X(93)90028-W</identifier><identifier>PMID: 8289082</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Age at onset ; Age of Onset ; Aged ; Anti-muscle antibodies ; Anti-receptor antibodies ; Autoantibodies - blood ; Child ; Citric acid muscle extract ; Enzyme-Linked Immunosorbent Assay ; Female ; Fluorescent Antibody Technique ; Humans ; Male ; Middle Aged ; Muscles - immunology ; Myasthenia gravis ; Myasthenia Gravis - blood ; Myasthenia Gravis - immunology ; Non-tumorous thymus ; Thymoma ; Thymus Neoplasms</subject><ispartof>Journal of the neurological sciences, 1993-12, Vol.120 (1), p.78-81</ispartof><rights>1993</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0022-510X(93)90028-W$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8289082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuks, J.B.M.</creatorcontrib><creatorcontrib>Limburg, P.C.</creatorcontrib><creatorcontrib>Horst, G.</creatorcontrib><creatorcontrib>Oosterhuis, H.J.G.H.</creatorcontrib><title>Antibodies to skeletal muscle in myasthenia gravis: Part 2. Prevalence in non-thymoma patients</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>Anti-skeletal muscle antibodies (AMA) were measured in 340 non-thymoma patients with myasthenia gravis (MG) by both an ELISA with citric acid muscle extract and by immunofluorescence assay. Three a-AChR negative but AMA-positive patients were found. The occurrence of AMA was related to the age at onset in patients with an onset of MG beyond 40 years and with duration of disease in patients with an earlier onset of MG. This stresses the heterogeneity of late onset and early onset MG. Serial measurements in individual patients revealed no evidence for a thymic role in the generation of AMA. There was no difference in specificity of AMA in early and late onset patients. The presence of AMA in CT-negative patients is not necessarily suggestive of a radiological shortcoming in the detection of thymoma since in 16 AMA-positive patients from our series no thymoma was found at operation or obduction.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age at onset</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Anti-muscle antibodies</subject><subject>Anti-receptor antibodies</subject><subject>Autoantibodies - blood</subject><subject>Child</subject><subject>Citric acid muscle extract</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscles - immunology</subject><subject>Myasthenia gravis</subject><subject>Myasthenia Gravis - blood</subject><subject>Myasthenia Gravis - immunology</subject><subject>Non-tumorous thymus</subject><subject>Thymoma</subject><subject>Thymus Neoplasms</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU1LAzEQhoMotVb_gUJOoofVZHezm3gQSvELCvag1JMhm0xtdD9qki3037vbFk8zw_swzLwvQueU3FBCs1tC4jhilHxcieRadBOP5gdoSHnOI8Z5coiG_8gxOvH-mxCScS4GaMBjLgiPh-hzXAdbNMaCx6HB_gdKCKrEVet1CdjWuNooH5ZQW4W_nFpbf4dnygUc3-CZg7UqodZbsG7qKCw3VVMpvFLBQh38KTpaqNLD2b6O0Pvjw9vkOZq-Pr1MxtMIaJ6FyChKs0V3k05TLajgbJGafEELpnOAVFFIqTGMZQUhghVdw7SJBU1YnheGm2SELnd7V675bcEHWVmvoSxVDU3rZZ7RLEmzvAMv9mBbVGDkytlKuY3cG9Lp9zsdumvXFpz02vYfGutAB2kaKymRfQCyd1f27kqRyG0Acp78AcKVd6c</recordid><startdate>19931201</startdate><enddate>19931201</enddate><creator>Kuks, J.B.M.</creator><creator>Limburg, P.C.</creator><creator>Horst, G.</creator><creator>Oosterhuis, H.J.G.H.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19931201</creationdate><title>Antibodies to skeletal muscle in myasthenia gravis: Part 2. Prevalence in non-thymoma patients</title><author>Kuks, J.B.M. ; Limburg, P.C. ; Horst, G. ; Oosterhuis, H.J.G.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e176t-da116f289c44c91985f4d7f1b5c7ee4a1e41dd556b0095b5565cd2913577bd8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age at onset</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Anti-muscle antibodies</topic><topic>Anti-receptor antibodies</topic><topic>Autoantibodies - blood</topic><topic>Child</topic><topic>Citric acid muscle extract</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Fluorescent Antibody Technique</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscles - immunology</topic><topic>Myasthenia gravis</topic><topic>Myasthenia Gravis - blood</topic><topic>Myasthenia Gravis - immunology</topic><topic>Non-tumorous thymus</topic><topic>Thymoma</topic><topic>Thymus Neoplasms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuks, J.B.M.</creatorcontrib><creatorcontrib>Limburg, P.C.</creatorcontrib><creatorcontrib>Horst, G.</creatorcontrib><creatorcontrib>Oosterhuis, H.J.G.H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuks, J.B.M.</au><au>Limburg, P.C.</au><au>Horst, G.</au><au>Oosterhuis, H.J.G.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibodies to skeletal muscle in myasthenia gravis: Part 2. Prevalence in non-thymoma patients</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1993-12-01</date><risdate>1993</risdate><volume>120</volume><issue>1</issue><spage>78</spage><epage>81</epage><pages>78-81</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><abstract>Anti-skeletal muscle antibodies (AMA) were measured in 340 non-thymoma patients with myasthenia gravis (MG) by both an ELISA with citric acid muscle extract and by immunofluorescence assay. Three a-AChR negative but AMA-positive patients were found. The occurrence of AMA was related to the age at onset in patients with an onset of MG beyond 40 years and with duration of disease in patients with an earlier onset of MG. This stresses the heterogeneity of late onset and early onset MG. Serial measurements in individual patients revealed no evidence for a thymic role in the generation of AMA. There was no difference in specificity of AMA in early and late onset patients. The presence of AMA in CT-negative patients is not necessarily suggestive of a radiological shortcoming in the detection of thymoma since in 16 AMA-positive patients from our series no thymoma was found at operation or obduction.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>8289082</pmid><doi>10.1016/0022-510X(93)90028-W</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-510X |
| ispartof | Journal of the neurological sciences, 1993-12, Vol.120 (1), p.78-81 |
| issn | 0022-510X 1878-5883 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76163467 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adolescent Adult Age at onset Age of Onset Aged Anti-muscle antibodies Anti-receptor antibodies Autoantibodies - blood Child Citric acid muscle extract Enzyme-Linked Immunosorbent Assay Female Fluorescent Antibody Technique Humans Male Middle Aged Muscles - immunology Myasthenia gravis Myasthenia Gravis - blood Myasthenia Gravis - immunology Non-tumorous thymus Thymoma Thymus Neoplasms |
| title | Antibodies to skeletal muscle in myasthenia gravis: Part 2. Prevalence in non-thymoma patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T18%3A37%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antibodies%20to%20skeletal%20muscle%20in%20myasthenia%20gravis:%20Part%202.%20Prevalence%20in%20non-thymoma%20patients&rft.jtitle=Journal%20of%20the%20neurological%20sciences&rft.au=Kuks,%20J.B.M.&rft.date=1993-12-01&rft.volume=120&rft.issue=1&rft.spage=78&rft.epage=81&rft.pages=78-81&rft.issn=0022-510X&rft.eissn=1878-5883&rft_id=info:doi/10.1016/0022-510X(93)90028-W&rft_dat=%3Cproquest_pubme%3E76163467%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76163467&rft_id=info:pmid/8289082&rft_els_id=0022510X9390028W&rfr_iscdi=true |