Glial cell component in retinoblastoma
The right eye of a 4-month-old girl with a large, unilateral, sporadic retinoblastoma was enucleated. The tumor was unusual because it contained Flexner-Wintersteiner rosettes with extremely large lumina. Smaller rosettes and undifferentiated tumor cells were observed within the lumina. Also of impo...
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| Veröffentlicht in: | Experimental eye research 1985-05, Vol.40 (5), p.647,IN1,657-656,IN2,659 |
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| container_end_page | 656,IN2,659 |
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| container_issue | 5 |
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| container_title | Experimental eye research |
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| creator | Craft, Joseph L. Sang, Delia N. Dryja, Thaddeus P. Brockhurst, Robert J. Robinson, Nancy L. Albert, Daniel M. |
| description | The right eye of a 4-month-old girl with a large, unilateral, sporadic retinoblastoma was enucleated. The tumor was unusual because it contained Flexner-Wintersteiner rosettes with extremely large lumina. Smaller rosettes and undifferentiated tumor cells were observed within the lumina. Also of importance were cells resembling glial cells which were intermixed with more typical cuboidal retinoblastoma cells. These cells had electron microscopic features typical of glial cells and stained positively for glial fibrillary acidic protein in immunohistochemical studies. Rosettes and glial cells continued to be observed in the tumor carried in tissue culture through two passages over a 7-month period. This tumor is presented because of its unusual rosette structures and because it confirms recent reports describing a glial cell component in retinoblastoma. |
| doi_str_mv | 10.1016/0014-4835(85)90134-4 |
| format | Article |
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The tumor was unusual because it contained Flexner-Wintersteiner rosettes with extremely large lumina. Smaller rosettes and undifferentiated tumor cells were observed within the lumina. Also of importance were cells resembling glial cells which were intermixed with more typical cuboidal retinoblastoma cells. These cells had electron microscopic features typical of glial cells and stained positively for glial fibrillary acidic protein in immunohistochemical studies. Rosettes and glial cells continued to be observed in the tumor carried in tissue culture through two passages over a 7-month period. 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The tumor was unusual because it contained Flexner-Wintersteiner rosettes with extremely large lumina. Smaller rosettes and undifferentiated tumor cells were observed within the lumina. Also of importance were cells resembling glial cells which were intermixed with more typical cuboidal retinoblastoma cells. These cells had electron microscopic features typical of glial cells and stained positively for glial fibrillary acidic protein in immunohistochemical studies. Rosettes and glial cells continued to be observed in the tumor carried in tissue culture through two passages over a 7-month period. This tumor is presented because of its unusual rosette structures and because it confirms recent reports describing a glial cell component in retinoblastoma.</description><subject>Astrocytes - ultrastructure</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Eye Neoplasms - ultrastructure</subject><subject>Female</subject><subject>glial cells</subject><subject>Glial Fibrillary Acidic Protein - analysis</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Infant</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Neuroglia - ultrastructure</subject><subject>Ophthalmology</subject><subject>Retina - ultrastructure</subject><subject>retinoblastoma</subject><subject>Retinoblastoma - ultrastructure</subject><subject>Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus</subject><issn>0014-4835</issn><issn>1096-0007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo67r6DxT2IIseqkknH81FkEVXYcGLnkOapBBpmzXpCv57W1v26GWGmXlmeOdF6JLgO4IJv8eY0IwWwG4Kdisxgb46QnOCJc8wxuIYzQ_IKTpL6bPvAhV0hmZQSAIyn6PVpva6XhpX9yE0u9C6tlv6dhld59tQ1jp1odHn6KTSdXIXU16gj-en9_VLtn3bvK4ft5mBgneZFEA101Ya0NiUznIGvKxYVWFuWaGJ0ZJhSaW0YCiYnApiZWlkTkwpQMICrca7uxi-9i51qvFpEKdbF_ZJCU44gGA9SEfQxJBSdJXaRd_o-KMIVoM9avhdDb-rgqk_exTt166m-_uycfawNPnRz6-nuU5G11XUrfHpgBVM5lgMMh9GzPVefHsXVTLetcZZH53plA3-fx2_6zZ_Og</recordid><startdate>198505</startdate><enddate>198505</enddate><creator>Craft, Joseph L.</creator><creator>Sang, Delia N.</creator><creator>Dryja, Thaddeus P.</creator><creator>Brockhurst, Robert J.</creator><creator>Robinson, Nancy L.</creator><creator>Albert, Daniel M.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198505</creationdate><title>Glial cell component in retinoblastoma</title><author>Craft, Joseph L. ; Sang, Delia N. ; Dryja, Thaddeus P. ; Brockhurst, Robert J. ; Robinson, Nancy L. ; Albert, Daniel M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-9734a5ad9c3a0cbed6536bf5ff06d58a1ca9509499d3c43c2471d9bc921cb7393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Astrocytes - ultrastructure</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Eye Neoplasms - ultrastructure</topic><topic>Female</topic><topic>glial cells</topic><topic>Glial Fibrillary Acidic Protein - analysis</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Infant</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Neuroglia - ultrastructure</topic><topic>Ophthalmology</topic><topic>Retina - ultrastructure</topic><topic>retinoblastoma</topic><topic>Retinoblastoma - ultrastructure</topic><topic>Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Craft, Joseph L.</creatorcontrib><creatorcontrib>Sang, Delia N.</creatorcontrib><creatorcontrib>Dryja, Thaddeus P.</creatorcontrib><creatorcontrib>Brockhurst, Robert J.</creatorcontrib><creatorcontrib>Robinson, Nancy L.</creatorcontrib><creatorcontrib>Albert, Daniel M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental eye research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Craft, Joseph L.</au><au>Sang, Delia N.</au><au>Dryja, Thaddeus P.</au><au>Brockhurst, Robert J.</au><au>Robinson, Nancy L.</au><au>Albert, Daniel M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glial cell component in retinoblastoma</atitle><jtitle>Experimental eye research</jtitle><addtitle>Exp Eye Res</addtitle><date>1985-05</date><risdate>1985</risdate><volume>40</volume><issue>5</issue><spage>647,IN1,657</spage><epage>656,IN2,659</epage><pages>647,IN1,657-656,IN2,659</pages><issn>0014-4835</issn><eissn>1096-0007</eissn><coden>EXERA6</coden><abstract>The right eye of a 4-month-old girl with a large, unilateral, sporadic retinoblastoma was enucleated. The tumor was unusual because it contained Flexner-Wintersteiner rosettes with extremely large lumina. Smaller rosettes and undifferentiated tumor cells were observed within the lumina. Also of importance were cells resembling glial cells which were intermixed with more typical cuboidal retinoblastoma cells. These cells had electron microscopic features typical of glial cells and stained positively for glial fibrillary acidic protein in immunohistochemical studies. Rosettes and glial cells continued to be observed in the tumor carried in tissue culture through two passages over a 7-month period. This tumor is presented because of its unusual rosette structures and because it confirms recent reports describing a glial cell component in retinoblastoma.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>3891392</pmid><doi>10.1016/0014-4835(85)90134-4</doi><tpages>13</tpages></addata></record> |
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| ispartof | Experimental eye research, 1985-05, Vol.40 (5), p.647,IN1,657-656,IN2,659 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Astrocytes - ultrastructure Biological and medical sciences Cells, Cultured Eye Neoplasms - ultrastructure Female glial cells Glial Fibrillary Acidic Protein - analysis Humans Immunoenzyme Techniques Infant Medical sciences Microscopy, Electron Neuroglia - ultrastructure Ophthalmology Retina - ultrastructure retinoblastoma Retinoblastoma - ultrastructure Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus |
| title | Glial cell component in retinoblastoma |
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