DNA alkali-labile sites induced by incorporation of 5-aza-2'-deoxycytidine into DNA of mouse leukemia L1210 cells

The effects of 5-aza-2'-deoxycytidine on DNA in mouse L1210 leukemia cells were investigated using the alkaline elution technique. By comparing the DNA elution rate at pH 12.1 and 12.6, it was found that the drug produced DNA alkali-labile lesions. Alkali-labile sites were present only in DNA s...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1985-07, Vol.45 (7), p.3197-3202
Hauptverfasser:	DINCALCI, M, COVEY, J. M, ZAHARKO, D. S, KOHN, K. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkalies Animals Antineoplastic agents Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Azacitidine - analogs & derivatives Azacitidine - metabolism Azacitidine - pharmacology Biological and medical sciences Cells, Cultured DNA, Neoplasm - metabolism General aspects Hydrogen-Ion Concentration Leukemia L1210 - metabolism Medical sciences Mice Pharmacology. Drug treatments
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