Enhanced interleukin 1 (IL-1) production mediated by mouse serum amyloid P component
Purified serum amyloid P component (SAP), the major acute-phase reactant of mice, induces enhanced interleukin 1 (IL-1) production by elicited monocytes/macrophages in vitro. SAP also enhanced IL-1 elaboration by macrophages from lipopolysaccharide (LPS)-low responder mice and in the presence of pol...
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| Veröffentlicht in: | Cellular immunology 1985-01, Vol.93 (2), p.398-405 |
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| creator | Sarlo, Katherine T. Mortensen, Richard F. |
| description | Purified serum amyloid P component (SAP), the major acute-phase reactant of mice, induces enhanced interleukin 1 (IL-1) production by elicited monocytes/macrophages
in vitro. SAP also enhanced IL-1 elaboration by macrophages from lipopolysaccharide (LPS)-low responder mice and in the presence of polymyxin B, indicating that the small amounts of LPS present in the SAP preparation did not augment IL-1 production. Concentrations of SAP of 0.1 to 10.0 μg/ml enhanced IL-1 production by elicited and bacillus Calmette-Guerin (BCG)-activated peritoneal macrophages, but not by resident peritoneal macrophages. The inflammation-induced monocyte/macrophage population displayed selective binding of SAP. The mouse macrophage line P388D
1, also could bind SAP and display enhanced IL-1 production in response to SAP. SAP did not bind to the macrophage cell line RAW264.7 nor did it enhance IL-1 secretion by this line. The results suggest that this acute-phase reactant has the potential to enhance inflammatory and immunological events mediated by IL-1. |
| doi_str_mv | 10.1016/0008-8749(85)90144-3 |
| format | Article |
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in vitro. SAP also enhanced IL-1 elaboration by macrophages from lipopolysaccharide (LPS)-low responder mice and in the presence of polymyxin B, indicating that the small amounts of LPS present in the SAP preparation did not augment IL-1 production. Concentrations of SAP of 0.1 to 10.0 μg/ml enhanced IL-1 production by elicited and bacillus Calmette-Guerin (BCG)-activated peritoneal macrophages, but not by resident peritoneal macrophages. The inflammation-induced monocyte/macrophage population displayed selective binding of SAP. The mouse macrophage line P388D
1, also could bind SAP and display enhanced IL-1 production in response to SAP. SAP did not bind to the macrophage cell line RAW264.7 nor did it enhance IL-1 secretion by this line. The results suggest that this acute-phase reactant has the potential to enhance inflammatory and immunological events mediated by IL-1.</description><subject>Amyloid - blood</subject><subject>Amyloid - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Inflammation</subject><subject>Interleukin-1 - biosynthesis</subject><subject>Macrophages - classification</subject><subject>Macrophages - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Molecular and cellular biology</subject><subject>Serum Amyloid P-Component</subject><issn>0008-8749</issn><issn>1090-2163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EKkvhH4DkA6raQ8o4dvxxQUJVC5VWoodythx7Igz5WOwEaf99HXa1x3Kaw_vM6NUzhLxncM2AyU8AoCuthLnUzZUBJkTFX5ANAwNVzSR_STYn5DV5k_MvAMaEgTNyxrXixqgNebwdf7rRY6BxnDH1uPyOI2X08n5bsSu6S1NY_BynkQ4YopsL2O7pMC0Zaca0DNQN-36KgT5QPw27acRxfkteda7P-O44z8mPu9vHm2_V9vvX-5sv28oLpuZKBwyOg5dcCgiK17Jr6g5q6KD1QkvXtbwxjXSa1851iik0jksv29aFGgQ_JxeHu6XmnwXzbIeYPfa9G7E0tEoyWUyY_4JM8IYpCQUUB9CnKeeEnd2lOLi0twzsat2uSu2q1OrG_rNueVn7cLy_tMXTaemoueQfj7nL3vVdKspjPmFaqto0K_b5gGGR9jdistlHXL8TE_rZhik-3-MJ9iGclg</recordid><startdate>19850101</startdate><enddate>19850101</enddate><creator>Sarlo, Katherine T.</creator><creator>Mortensen, Richard F.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19850101</creationdate><title>Enhanced interleukin 1 (IL-1) production mediated by mouse serum amyloid P component</title><author>Sarlo, Katherine T. ; Mortensen, Richard F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-8deda30c63640d7326f52f020f0bc486afb35956a832aaf717e9a36c6bbad2043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Amyloid - blood</topic><topic>Amyloid - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Inflammation</topic><topic>Interleukin-1 - biosynthesis</topic><topic>Macrophages - classification</topic><topic>Macrophages - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Molecular and cellular biology</topic><topic>Serum Amyloid P-Component</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sarlo, Katherine T.</creatorcontrib><creatorcontrib>Mortensen, Richard F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sarlo, Katherine T.</au><au>Mortensen, Richard F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced interleukin 1 (IL-1) production mediated by mouse serum amyloid P component</atitle><jtitle>Cellular immunology</jtitle><addtitle>Cell Immunol</addtitle><date>1985-01-01</date><risdate>1985</risdate><volume>93</volume><issue>2</issue><spage>398</spage><epage>405</epage><pages>398-405</pages><issn>0008-8749</issn><eissn>1090-2163</eissn><coden>CLIMB8</coden><abstract>Purified serum amyloid P component (SAP), the major acute-phase reactant of mice, induces enhanced interleukin 1 (IL-1) production by elicited monocytes/macrophages
in vitro. SAP also enhanced IL-1 elaboration by macrophages from lipopolysaccharide (LPS)-low responder mice and in the presence of polymyxin B, indicating that the small amounts of LPS present in the SAP preparation did not augment IL-1 production. Concentrations of SAP of 0.1 to 10.0 μg/ml enhanced IL-1 production by elicited and bacillus Calmette-Guerin (BCG)-activated peritoneal macrophages, but not by resident peritoneal macrophages. The inflammation-induced monocyte/macrophage population displayed selective binding of SAP. The mouse macrophage line P388D
1, also could bind SAP and display enhanced IL-1 production in response to SAP. SAP did not bind to the macrophage cell line RAW264.7 nor did it enhance IL-1 secretion by this line. The results suggest that this acute-phase reactant has the potential to enhance inflammatory and immunological events mediated by IL-1.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>3873997</pmid><doi>10.1016/0008-8749(85)90144-3</doi><tpages>8</tpages></addata></record> |
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| ispartof | Cellular immunology, 1985-01, Vol.93 (2), p.398-405 |
| issn | 0008-8749 1090-2163 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Amyloid - blood Amyloid - pharmacology Animals Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Inflammation Interleukin-1 - biosynthesis Macrophages - classification Macrophages - metabolism Mice Mice, Inbred Strains Molecular and cellular biology Serum Amyloid P-Component |
| title | Enhanced interleukin 1 (IL-1) production mediated by mouse serum amyloid P component |
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