Measurement of Urine Prostaglandin E2 as a Predictor of Acute Renal Transplant Rejection: Preliminary Findings
A radioimmunoassay for prostaglandin E2 (PGE2) in urine was developed and validated. It was used to provide serial measurements in eight renal transplant patients. Urine PGE2 concentration was increased between 1 and 7 days before any changes in the conventional biochemical indicators of acute rejec...
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| Veröffentlicht in: | Annals of clinical biochemistry 1985-03, Vol.22 (2), p.161-165 |
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| container_title | Annals of clinical biochemistry |
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| creator | Thompson, D Rowe, D J F Briggs, J D |
| description | A radioimmunoassay for prostaglandin E2 (PGE2) in urine was developed and validated. It was used to provide serial measurements in eight renal transplant patients. Urine PGE2 concentration was increased between 1 and 7 days before any changes in the conventional biochemical indicators of acute rejection, serum creatinine and creatinine clearance. The increases in PGE2 concentration varied from 3 to 50 times that of the previous day. These results suggest that measurement of urinary PGE2 may be useful as an early indicator of acute renal transplant rejection. |
| doi_str_mv | 10.1177/000456328502200210 |
| format | Article |
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It was used to provide serial measurements in eight renal transplant patients. Urine PGE2 concentration was increased between 1 and 7 days before any changes in the conventional biochemical indicators of acute rejection, serum creatinine and creatinine clearance. The increases in PGE2 concentration varied from 3 to 50 times that of the previous day. These results suggest that measurement of urinary PGE2 may be useful as an early indicator of acute renal transplant rejection.</description><identifier>ISSN: 0004-5632</identifier><identifier>EISSN: 1758-1001</identifier><identifier>DOI: 10.1177/000456328502200210</identifier><identifier>PMID: 3890681</identifier><identifier>CODEN: ACBOBU</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Acute Disease ; Biological and medical sciences ; Creatinine - blood ; Creatinine - metabolism ; Dinoprostone ; Female ; Graft Rejection ; Humans ; Kidney Transplantation ; Male ; Medical sciences ; Prostaglandins E - blood ; Radioimmunoassay ; Surgery (general aspects). Transplantations, organ and tissue grafts. 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It was used to provide serial measurements in eight renal transplant patients. Urine PGE2 concentration was increased between 1 and 7 days before any changes in the conventional biochemical indicators of acute rejection, serum creatinine and creatinine clearance. The increases in PGE2 concentration varied from 3 to 50 times that of the previous day. These results suggest that measurement of urinary PGE2 may be useful as an early indicator of acute renal transplant rejection.</description><subject>Acute Disease</subject><subject>Biological and medical sciences</subject><subject>Creatinine - blood</subject><subject>Creatinine - metabolism</subject><subject>Dinoprostone</subject><subject>Female</subject><subject>Graft Rejection</subject><subject>Humans</subject><subject>Kidney Transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Prostaglandins E - blood</subject><subject>Radioimmunoassay</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><issn>0004-5632</issn><issn>1758-1001</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpl0c1q3DAQAGBRWtJt0hcIBHQIubmZkVeSnVsISVtIaQnJ2Yzl8aLFlreSfcjbRyZLLz0JzXwM8yPEOcI3RGuvAWCrTakqDUoBKIQPYoNWVwUC4EexWUGxis_iS0r7_FUW4ESclFUNpsKNCL-Y0hJ55DDLqZcv0QeWf-KUZtoNFDof5L2SlCTlKHfezVNc4a1bZpZPHGiQz5FCOmQ958Ce3eyncLPywY8-UHyVD36ttEtn4lNPQ-Kvx_dUvDzcP9_9KB5_f_95d_tYHJTVc1E76oxRjL3Tru07asGYUrcloyLtSCFWLTmuGbcOAcm0ulfK1LYHW6MuT8XVe91DnP4unOZm9MnxkHvkaUmNNWgUoM3w4giXduSuOUQ_5oab44Jy_vKYp-Ro6POkzqd_rNpWxsA2s-t3lmjHzX5aYt5LahCa9VDN_4cq3wA0K4K9</recordid><startdate>198503</startdate><enddate>198503</enddate><creator>Thompson, D</creator><creator>Rowe, D J F</creator><creator>Briggs, J D</creator><general>SAGE Publications</general><general>Royal Society of Medicine Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198503</creationdate><title>Measurement of Urine Prostaglandin E2 as a Predictor of Acute Renal Transplant Rejection: Preliminary Findings</title><author>Thompson, D ; Rowe, D J F ; Briggs, J D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p275t-9cad662e1fc5cbfdab06635b3e12a5ca2118bace9e14c101a6b5f22697f079153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Acute Disease</topic><topic>Biological and medical sciences</topic><topic>Creatinine - blood</topic><topic>Creatinine - metabolism</topic><topic>Dinoprostone</topic><topic>Female</topic><topic>Graft Rejection</topic><topic>Humans</topic><topic>Kidney Transplantation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Prostaglandins E - blood</topic><topic>Radioimmunoassay</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thompson, D</creatorcontrib><creatorcontrib>Rowe, D J F</creatorcontrib><creatorcontrib>Briggs, J D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thompson, D</au><au>Rowe, D J F</au><au>Briggs, J D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measurement of Urine Prostaglandin E2 as a Predictor of Acute Renal Transplant Rejection: Preliminary Findings</atitle><jtitle>Annals of clinical biochemistry</jtitle><addtitle>Ann Clin Biochem</addtitle><date>1985-03</date><risdate>1985</risdate><volume>22</volume><issue>2</issue><spage>161</spage><epage>165</epage><pages>161-165</pages><issn>0004-5632</issn><eissn>1758-1001</eissn><coden>ACBOBU</coden><abstract>A radioimmunoassay for prostaglandin E2 (PGE2) in urine was developed and validated. It was used to provide serial measurements in eight renal transplant patients. Urine PGE2 concentration was increased between 1 and 7 days before any changes in the conventional biochemical indicators of acute rejection, serum creatinine and creatinine clearance. The increases in PGE2 concentration varied from 3 to 50 times that of the previous day. These results suggest that measurement of urinary PGE2 may be useful as an early indicator of acute renal transplant rejection.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>3890681</pmid><doi>10.1177/000456328502200210</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0004-5632 |
| ispartof | Annals of clinical biochemistry, 1985-03, Vol.22 (2), p.161-165 |
| issn | 0004-5632 1758-1001 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76162017 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Acute Disease Biological and medical sciences Creatinine - blood Creatinine - metabolism Dinoprostone Female Graft Rejection Humans Kidney Transplantation Male Medical sciences Prostaglandins E - blood Radioimmunoassay Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system |
| title | Measurement of Urine Prostaglandin E2 as a Predictor of Acute Renal Transplant Rejection: Preliminary Findings |
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