Effects of 2-carboxythylgerumanium sesquioxide (Ge-132) as an immunological modifier of post-surgical immunosuppression in dogs
The effect of 2-carboxythylgerumanium sesquioxide (Ge-132) as an interferon-gamma (IFN-γ) inducer on post-surgical immunosuppression was evaluated from the immunological response augmented in canine neutrophils, macrophages and peripheral blood lymphocytes (PBL) using the chemiluminescence technique...
Gespeichert in:
| Veröffentlicht in: | Journal of Veterinary Medical Science 1993/10/15, Vol.55(5), pp.795-799 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 799 |
|---|---|
| container_issue | 5 |
| container_start_page | 795 |
| container_title | Journal of Veterinary Medical Science |
| container_volume | 55 |
| creator | Nakada, Y. (Nihon Univ., Tokyo (Japan). Coll. of Agriculture and Veterinary Medicine) Kosaka, T Kuwabaya, M Tanaka, S Sato, K Koide, F |
| description | The effect of 2-carboxythylgerumanium sesquioxide (Ge-132) as an interferon-gamma (IFN-γ) inducer on post-surgical immunosuppression was evaluated from the immunological response augmented in canine neutrophils, macrophages and peripheral blood lymphocytes (PBL) using the chemiluminescence technique. Experimental gastrotomy was performed on dogs in two groups; one group was subjected to sham-surgery without any medication, and the other was treated by Ge-132 administration at 24 hr before operation. Although the phagocytic activities of neutrophils, macrophages and PBL in the sham-operated group were depressed transiently after surgery, those in the Ge-132-administered group (Ge-132 group) were enhanced for a long time after surgery. It appeared that the generated free radical, which blocked the phagocytosis of macrophages and PBL, was activated by IFN-γ. These results suggest that Ge-132 pre-treatment may be efficacious and useful in preventing the multifaceted clinical symptoms induced by post-operative immunosuppression in dogs. |
| doi_str_mv | 10.1292/jvms.55.795 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76159705</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76159705</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3165-a44fdf21531cfe94328bf61431de65a0b3c68e83af9376a499931a1c7f3875ba3</originalsourceid><addsrcrecordid>eNo9kL1v1DAYhy0EKkdhYkNCyoRAVY44_orHqpSWqhIMMFuO8zr1KYlTvwnqTf3XyZHTLfbwPO8z_Ah5T4stLXX5dfe3x60QW6XFC7KhjKtccaZfkk2hqcxVKYrX5A3irihKyqU-I2dVWUnB2IY8X3sPbsIs-qzMnU11fNpPD_uuhTT3dghznyHg4xziU2gg-3wDOWXll8xiZocs9P08xC62wdku62MTfIB0iI0RpxzntJLVw3kcEyCGuFwOWRNbfEteedshvDv-5-TP9-vfV7f5_c-bH1eX97ljVIrccu4bX1LBqPOgOSur2kvKGW1AClvUzMkKKma9ZkparrVm1FKnPKuUqC07J5_W7pji4ww4mT6gg66zA8QZjZJUaFWIRbxYRZciYgJvxhR6m_aGFuYwtznMbYQwy9yL_fGYnesempN73Hfh31a-w8m2cOI2TcF18L9FtaaHnlifJXvC7sEmA8OS-bBmvI3GtimgufuleSElV-wf4EieAw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76159705</pqid></control><display><type>article</type><title>Effects of 2-carboxythylgerumanium sesquioxide (Ge-132) as an immunological modifier of post-surgical immunosuppression in dogs</title><source>J-STAGE Free</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Nakada, Y. (Nihon Univ., Tokyo (Japan). Coll. of Agriculture and Veterinary Medicine) ; Kosaka, T ; Kuwabaya, M ; Tanaka, S ; Sato, K ; Koide, F</creator><creatorcontrib>Nakada, Y. (Nihon Univ., Tokyo (Japan). Coll. of Agriculture and Veterinary Medicine) ; Kosaka, T ; Kuwabaya, M ; Tanaka, S ; Sato, K ; Koide, F</creatorcontrib><description>The effect of 2-carboxythylgerumanium sesquioxide (Ge-132) as an interferon-gamma (IFN-γ) inducer on post-surgical immunosuppression was evaluated from the immunological response augmented in canine neutrophils, macrophages and peripheral blood lymphocytes (PBL) using the chemiluminescence technique. Experimental gastrotomy was performed on dogs in two groups; one group was subjected to sham-surgery without any medication, and the other was treated by Ge-132 administration at 24 hr before operation. Although the phagocytic activities of neutrophils, macrophages and PBL in the sham-operated group were depressed transiently after surgery, those in the Ge-132-administered group (Ge-132 group) were enhanced for a long time after surgery. It appeared that the generated free radical, which blocked the phagocytosis of macrophages and PBL, was activated by IFN-γ. These results suggest that Ge-132 pre-treatment may be efficacious and useful in preventing the multifaceted clinical symptoms induced by post-operative immunosuppression in dogs.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.55.795</identifier><identifier>PMID: 8286533</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>Animals ; Cell Line ; chemiluminescence ; CHIEN ; DOGS ; DRUGS ; EVALUACION ; EVALUATION ; FACTEUR IMMUNOLOGIQUE ; FACTORES INMUNOLOGICOS ; FAGOCITOS ; Female ; Ge-132 ; Germanium - pharmacology ; IMMUNODEPRESSEUR ; IMMUNOLOGICAL FACTORS ; IMMUNOSUPPRESSANTS ; Immunosuppression - veterinary ; INMUNODEPRESORES ; INTERFERON ; Interferon Inducers - pharmacology ; Interferon-gamma - biosynthesis ; INTERFERONAS ; INTERFERONS ; Leukocyte Count - drug effects ; Luminescent Measurements ; Lymphocytes - drug effects ; Lymphocytes - physiology ; Lymphoma, Non-Hodgkin ; macrophage ; Macrophages - drug effects ; Macrophages - physiology ; Male ; MEDICAMENT ; MEDICAMENTOS ; neutrophil ; OPERACIONES QUIRURGICAS ; OPERATION CHIRURGICALE ; Organometallic Compounds - pharmacology ; PBL ; PERRO ; PHAGOCYTE ; PHAGOCYTES ; Phagocytosis - drug effects ; Stomach - surgery ; SURGICAL OPERATIONS ; Time Factors ; Tumor Cells, Cultured</subject><ispartof>Journal of Veterinary Medical Science, 1993/10/15, Vol.55(5), pp.795-799</ispartof><rights>The Japanese Society of Veterinary Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3165-a44fdf21531cfe94328bf61431de65a0b3c68e83af9376a499931a1c7f3875ba3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8286533$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakada, Y. (Nihon Univ., Tokyo (Japan). Coll. of Agriculture and Veterinary Medicine)</creatorcontrib><creatorcontrib>Kosaka, T</creatorcontrib><creatorcontrib>Kuwabaya, M</creatorcontrib><creatorcontrib>Tanaka, S</creatorcontrib><creatorcontrib>Sato, K</creatorcontrib><creatorcontrib>Koide, F</creatorcontrib><title>Effects of 2-carboxythylgerumanium sesquioxide (Ge-132) as an immunological modifier of post-surgical immunosuppression in dogs</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>The effect of 2-carboxythylgerumanium sesquioxide (Ge-132) as an interferon-gamma (IFN-γ) inducer on post-surgical immunosuppression was evaluated from the immunological response augmented in canine neutrophils, macrophages and peripheral blood lymphocytes (PBL) using the chemiluminescence technique. Experimental gastrotomy was performed on dogs in two groups; one group was subjected to sham-surgery without any medication, and the other was treated by Ge-132 administration at 24 hr before operation. Although the phagocytic activities of neutrophils, macrophages and PBL in the sham-operated group were depressed transiently after surgery, those in the Ge-132-administered group (Ge-132 group) were enhanced for a long time after surgery. It appeared that the generated free radical, which blocked the phagocytosis of macrophages and PBL, was activated by IFN-γ. These results suggest that Ge-132 pre-treatment may be efficacious and useful in preventing the multifaceted clinical symptoms induced by post-operative immunosuppression in dogs.</description><subject>Animals</subject><subject>Cell Line</subject><subject>chemiluminescence</subject><subject>CHIEN</subject><subject>DOGS</subject><subject>DRUGS</subject><subject>EVALUACION</subject><subject>EVALUATION</subject><subject>FACTEUR IMMUNOLOGIQUE</subject><subject>FACTORES INMUNOLOGICOS</subject><subject>FAGOCITOS</subject><subject>Female</subject><subject>Ge-132</subject><subject>Germanium - pharmacology</subject><subject>IMMUNODEPRESSEUR</subject><subject>IMMUNOLOGICAL FACTORS</subject><subject>IMMUNOSUPPRESSANTS</subject><subject>Immunosuppression - veterinary</subject><subject>INMUNODEPRESORES</subject><subject>INTERFERON</subject><subject>Interferon Inducers - pharmacology</subject><subject>Interferon-gamma - biosynthesis</subject><subject>INTERFERONAS</subject><subject>INTERFERONS</subject><subject>Leukocyte Count - drug effects</subject><subject>Luminescent Measurements</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - physiology</subject><subject>Lymphoma, Non-Hodgkin</subject><subject>macrophage</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - physiology</subject><subject>Male</subject><subject>MEDICAMENT</subject><subject>MEDICAMENTOS</subject><subject>neutrophil</subject><subject>OPERACIONES QUIRURGICAS</subject><subject>OPERATION CHIRURGICALE</subject><subject>Organometallic Compounds - pharmacology</subject><subject>PBL</subject><subject>PERRO</subject><subject>PHAGOCYTE</subject><subject>PHAGOCYTES</subject><subject>Phagocytosis - drug effects</subject><subject>Stomach - surgery</subject><subject>SURGICAL OPERATIONS</subject><subject>Time Factors</subject><subject>Tumor Cells, Cultured</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kL1v1DAYhy0EKkdhYkNCyoRAVY44_orHqpSWqhIMMFuO8zr1KYlTvwnqTf3XyZHTLfbwPO8z_Ah5T4stLXX5dfe3x60QW6XFC7KhjKtccaZfkk2hqcxVKYrX5A3irihKyqU-I2dVWUnB2IY8X3sPbsIs-qzMnU11fNpPD_uuhTT3dghznyHg4xziU2gg-3wDOWXll8xiZocs9P08xC62wdku62MTfIB0iI0RpxzntJLVw3kcEyCGuFwOWRNbfEteedshvDv-5-TP9-vfV7f5_c-bH1eX97ljVIrccu4bX1LBqPOgOSur2kvKGW1AClvUzMkKKma9ZkparrVm1FKnPKuUqC07J5_W7pji4ww4mT6gg66zA8QZjZJUaFWIRbxYRZciYgJvxhR6m_aGFuYwtznMbYQwy9yL_fGYnesempN73Hfh31a-w8m2cOI2TcF18L9FtaaHnlifJXvC7sEmA8OS-bBmvI3GtimgufuleSElV-wf4EieAw</recordid><startdate>199310</startdate><enddate>199310</enddate><creator>Nakada, Y. (Nihon Univ., Tokyo (Japan). Coll. of Agriculture and Veterinary Medicine)</creator><creator>Kosaka, T</creator><creator>Kuwabaya, M</creator><creator>Tanaka, S</creator><creator>Sato, K</creator><creator>Koide, F</creator><general>JAPANESE SOCIETY OF VETERINARY SCIENCE</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199310</creationdate><title>Effects of 2-carboxythylgerumanium sesquioxide (Ge-132) as an immunological modifier of post-surgical immunosuppression in dogs</title><author>Nakada, Y. (Nihon Univ., Tokyo (Japan). Coll. of Agriculture and Veterinary Medicine) ; Kosaka, T ; Kuwabaya, M ; Tanaka, S ; Sato, K ; Koide, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3165-a44fdf21531cfe94328bf61431de65a0b3c68e83af9376a499931a1c7f3875ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Cell Line</topic><topic>chemiluminescence</topic><topic>CHIEN</topic><topic>DOGS</topic><topic>DRUGS</topic><topic>EVALUACION</topic><topic>EVALUATION</topic><topic>FACTEUR IMMUNOLOGIQUE</topic><topic>FACTORES INMUNOLOGICOS</topic><topic>FAGOCITOS</topic><topic>Female</topic><topic>Ge-132</topic><topic>Germanium - pharmacology</topic><topic>IMMUNODEPRESSEUR</topic><topic>IMMUNOLOGICAL FACTORS</topic><topic>IMMUNOSUPPRESSANTS</topic><topic>Immunosuppression - veterinary</topic><topic>INMUNODEPRESORES</topic><topic>INTERFERON</topic><topic>Interferon Inducers - pharmacology</topic><topic>Interferon-gamma - biosynthesis</topic><topic>INTERFERONAS</topic><topic>INTERFERONS</topic><topic>Leukocyte Count - drug effects</topic><topic>Luminescent Measurements</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - physiology</topic><topic>Lymphoma, Non-Hodgkin</topic><topic>macrophage</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - physiology</topic><topic>Male</topic><topic>MEDICAMENT</topic><topic>MEDICAMENTOS</topic><topic>neutrophil</topic><topic>OPERACIONES QUIRURGICAS</topic><topic>OPERATION CHIRURGICALE</topic><topic>Organometallic Compounds - pharmacology</topic><topic>PBL</topic><topic>PERRO</topic><topic>PHAGOCYTE</topic><topic>PHAGOCYTES</topic><topic>Phagocytosis - drug effects</topic><topic>Stomach - surgery</topic><topic>SURGICAL OPERATIONS</topic><topic>Time Factors</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakada, Y. (Nihon Univ., Tokyo (Japan). Coll. of Agriculture and Veterinary Medicine)</creatorcontrib><creatorcontrib>Kosaka, T</creatorcontrib><creatorcontrib>Kuwabaya, M</creatorcontrib><creatorcontrib>Tanaka, S</creatorcontrib><creatorcontrib>Sato, K</creatorcontrib><creatorcontrib>Koide, F</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakada, Y. (Nihon Univ., Tokyo (Japan). Coll. of Agriculture and Veterinary Medicine)</au><au>Kosaka, T</au><au>Kuwabaya, M</au><au>Tanaka, S</au><au>Sato, K</au><au>Koide, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of 2-carboxythylgerumanium sesquioxide (Ge-132) as an immunological modifier of post-surgical immunosuppression in dogs</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. Vet. Med. Sci.</addtitle><date>1993-10</date><risdate>1993</risdate><volume>55</volume><issue>5</issue><spage>795</spage><epage>799</epage><pages>795-799</pages><issn>0916-7250</issn><eissn>1347-7439</eissn><abstract>The effect of 2-carboxythylgerumanium sesquioxide (Ge-132) as an interferon-gamma (IFN-γ) inducer on post-surgical immunosuppression was evaluated from the immunological response augmented in canine neutrophils, macrophages and peripheral blood lymphocytes (PBL) using the chemiluminescence technique. Experimental gastrotomy was performed on dogs in two groups; one group was subjected to sham-surgery without any medication, and the other was treated by Ge-132 administration at 24 hr before operation. Although the phagocytic activities of neutrophils, macrophages and PBL in the sham-operated group were depressed transiently after surgery, those in the Ge-132-administered group (Ge-132 group) were enhanced for a long time after surgery. It appeared that the generated free radical, which blocked the phagocytosis of macrophages and PBL, was activated by IFN-γ. These results suggest that Ge-132 pre-treatment may be efficacious and useful in preventing the multifaceted clinical symptoms induced by post-operative immunosuppression in dogs.</abstract><cop>Japan</cop><pub>JAPANESE SOCIETY OF VETERINARY SCIENCE</pub><pmid>8286533</pmid><doi>10.1292/jvms.55.795</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0916-7250 |
| ispartof | Journal of Veterinary Medical Science, 1993/10/15, Vol.55(5), pp.795-799 |
| issn | 0916-7250 1347-7439 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76159705 |
| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Cell Line chemiluminescence CHIEN DOGS DRUGS EVALUACION EVALUATION FACTEUR IMMUNOLOGIQUE FACTORES INMUNOLOGICOS FAGOCITOS Female Ge-132 Germanium - pharmacology IMMUNODEPRESSEUR IMMUNOLOGICAL FACTORS IMMUNOSUPPRESSANTS Immunosuppression - veterinary INMUNODEPRESORES INTERFERON Interferon Inducers - pharmacology Interferon-gamma - biosynthesis INTERFERONAS INTERFERONS Leukocyte Count - drug effects Luminescent Measurements Lymphocytes - drug effects Lymphocytes - physiology Lymphoma, Non-Hodgkin macrophage Macrophages - drug effects Macrophages - physiology Male MEDICAMENT MEDICAMENTOS neutrophil OPERACIONES QUIRURGICAS OPERATION CHIRURGICALE Organometallic Compounds - pharmacology PBL PERRO PHAGOCYTE PHAGOCYTES Phagocytosis - drug effects Stomach - surgery SURGICAL OPERATIONS Time Factors Tumor Cells, Cultured |
| title | Effects of 2-carboxythylgerumanium sesquioxide (Ge-132) as an immunological modifier of post-surgical immunosuppression in dogs |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T08%3A24%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%202-carboxythylgerumanium%20sesquioxide%20(Ge-132)%20as%20an%20immunological%20modifier%20of%20post-surgical%20immunosuppression%20in%20dogs&rft.jtitle=Journal%20of%20Veterinary%20Medical%20Science&rft.au=Nakada,%20Y.%20(Nihon%20Univ.,%20Tokyo%20(Japan).%20Coll.%20of%20Agriculture%20and%20Veterinary%20Medicine)&rft.date=1993-10&rft.volume=55&rft.issue=5&rft.spage=795&rft.epage=799&rft.pages=795-799&rft.issn=0916-7250&rft.eissn=1347-7439&rft_id=info:doi/10.1292/jvms.55.795&rft_dat=%3Cproquest_cross%3E76159705%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76159705&rft_id=info:pmid/8286533&rfr_iscdi=true |