Effect of cyclosporin A on the non-MHC endothelial antibody response in the rat
The effect of cyclosporin A (CsA) on the in vivo humoral immune response against the non-MHC endothelial antigen that is present on the renal capillary and venous endothelium was tested in a rat model. Male MAXX rats were immunized using pooled spleen and lymph node cells from MHC-identical Brown No...
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| Veröffentlicht in: | Clinical immunology and immunopathology 1985-01, Vol.36 (2), p.249-253 |
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| container_title | Clinical immunology and immunopathology |
| container_volume | 36 |
| creator | Henny, Felix C. van Es, Leendert A. Paul, Leendert C. |
| description | The effect of cyclosporin A (CsA) on the
in vivo humoral immune response against the non-MHC endothelial antigen that is present on the renal capillary and venous endothelium was tested in a rat model. Male MAXX rats were immunized using pooled spleen and lymph node cells from MHC-identical Brown Norway rats to induce the endothelial antibody response. The animals were treated with different doses of CsA for different periods and it was found that CsA suppressed the response completely and irreversibly when administered in a dose of 15 mg/kg/day with a minimum duration of therapy for 2 weeks. Animals that received a lower dose (10 mg/kg/day) or 15 mg/kg/day for 1 week, did show an initial response but failed to respond after repeated immunizations. The results show that CsA suppresses the humoral response to non-MHC alloantigens. Furthermore, a state of nonresponsiveness appears to be induced with doses which are not effective in suppressing the initial antibody response. |
| doi_str_mv | 10.1016/0090-1229(85)90127-8 |
| format | Article |
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in vivo humoral immune response against the non-MHC endothelial antigen that is present on the renal capillary and venous endothelium was tested in a rat model. Male MAXX rats were immunized using pooled spleen and lymph node cells from MHC-identical Brown Norway rats to induce the endothelial antibody response. The animals were treated with different doses of CsA for different periods and it was found that CsA suppressed the response completely and irreversibly when administered in a dose of 15 mg/kg/day with a minimum duration of therapy for 2 weeks. Animals that received a lower dose (10 mg/kg/day) or 15 mg/kg/day for 1 week, did show an initial response but failed to respond after repeated immunizations. The results show that CsA suppresses the humoral response to non-MHC alloantigens. Furthermore, a state of nonresponsiveness appears to be induced with doses which are not effective in suppressing the initial antibody response.</description><identifier>ISSN: 0090-1229</identifier><identifier>EISSN: 1090-2341</identifier><identifier>DOI: 10.1016/0090-1229(85)90127-8</identifier><identifier>PMID: 3891176</identifier><identifier>CODEN: CLIIAT</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Animals ; Antibody Formation - drug effects ; Biological and medical sciences ; Blood Vessels - immunology ; Cyclosporins - pharmacology ; Endothelium - immunology ; Immunomodulators ; Isoantigens - immunology ; Kidney - blood supply ; Kidney Transplantation ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred BN ; Transplantation Immunology - drug effects</subject><ispartof>Clinical immunology and immunopathology, 1985-01, Vol.36 (2), p.249-253</ispartof><rights>1985</rights><rights>1985 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c366t-9c02bb5802089bdb6ece4fe22758ed4dbf3fd9b29d8ea3d66af281516ead615a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9285275$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3891176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Henny, Felix C.</creatorcontrib><creatorcontrib>van Es, Leendert A.</creatorcontrib><creatorcontrib>Paul, Leendert C.</creatorcontrib><title>Effect of cyclosporin A on the non-MHC endothelial antibody response in the rat</title><title>Clinical immunology and immunopathology</title><addtitle>Clin Immunol Immunopathol</addtitle><description>The effect of cyclosporin A (CsA) on the
in vivo humoral immune response against the non-MHC endothelial antigen that is present on the renal capillary and venous endothelium was tested in a rat model. Male MAXX rats were immunized using pooled spleen and lymph node cells from MHC-identical Brown Norway rats to induce the endothelial antibody response. The animals were treated with different doses of CsA for different periods and it was found that CsA suppressed the response completely and irreversibly when administered in a dose of 15 mg/kg/day with a minimum duration of therapy for 2 weeks. Animals that received a lower dose (10 mg/kg/day) or 15 mg/kg/day for 1 week, did show an initial response but failed to respond after repeated immunizations. The results show that CsA suppresses the humoral response to non-MHC alloantigens. Furthermore, a state of nonresponsiveness appears to be induced with doses which are not effective in suppressing the initial antibody response.</description><subject>Animals</subject><subject>Antibody Formation - drug effects</subject><subject>Biological and medical sciences</subject><subject>Blood Vessels - immunology</subject><subject>Cyclosporins - pharmacology</subject><subject>Endothelium - immunology</subject><subject>Immunomodulators</subject><subject>Isoantigens - immunology</subject><subject>Kidney - blood supply</subject><subject>Kidney Transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred BN</subject><subject>Transplantation Immunology - drug effects</subject><issn>0090-1229</issn><issn>1090-2341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFuGyEQhlHUyHXcvEEqcYii9LANsLssXCpFlhNHcuVLekYsDArVGlxYV_LbF8eWj-kJwf_NaOYDoRtKvlNC-QMhklSUMXkv2m-SUNZV4gJN6eGZ1Q39hKZn5DO6yvk3IYQ3pJugSS0kpR2fovXCOTAjjg6bvRli3sbkA37EMeDxDXCIofq5nGMINpb74PWAdRh9H-0eJyh4yID9EU56_IIunR4yXJ_OGfr1tHidL6vV-vll_riqTM35WElDWN-3gjAiZG97DgYaB4x1rQDb2N7VzsqeSStA15Zz7ZigLeWgLaetrmfo7th3m-KfHeRRbXw2MAw6QNxl1RVKNJz-F6QFaouXAjZH0KSYcwKntslvdNorStRBuDrYVAebSrTqXbgSpezrqf-u34A9F50Ml_z2lOts9OCSDsbnMyaZaMvSBftxxKBI--shqWw8BAPWp_I_ykb_8Rz_AH6nm4c</recordid><startdate>19850101</startdate><enddate>19850101</enddate><creator>Henny, Felix C.</creator><creator>van Es, Leendert A.</creator><creator>Paul, Leendert C.</creator><general>Elsevier Inc</general><general>Academic Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19850101</creationdate><title>Effect of cyclosporin A on the non-MHC endothelial antibody response in the rat</title><author>Henny, Felix C. ; van Es, Leendert A. ; Paul, Leendert C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-9c02bb5802089bdb6ece4fe22758ed4dbf3fd9b29d8ea3d66af281516ead615a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Antibody Formation - drug effects</topic><topic>Biological and medical sciences</topic><topic>Blood Vessels - immunology</topic><topic>Cyclosporins - pharmacology</topic><topic>Endothelium - immunology</topic><topic>Immunomodulators</topic><topic>Isoantigens - immunology</topic><topic>Kidney - blood supply</topic><topic>Kidney Transplantation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred BN</topic><topic>Transplantation Immunology - drug effects</topic><toplevel>online_resources</toplevel><creatorcontrib>Henny, Felix C.</creatorcontrib><creatorcontrib>van Es, Leendert A.</creatorcontrib><creatorcontrib>Paul, Leendert C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Henny, Felix C.</au><au>van Es, Leendert A.</au><au>Paul, Leendert C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of cyclosporin A on the non-MHC endothelial antibody response in the rat</atitle><jtitle>Clinical immunology and immunopathology</jtitle><addtitle>Clin Immunol Immunopathol</addtitle><date>1985-01-01</date><risdate>1985</risdate><volume>36</volume><issue>2</issue><spage>249</spage><epage>253</epage><pages>249-253</pages><issn>0090-1229</issn><eissn>1090-2341</eissn><coden>CLIIAT</coden><abstract>The effect of cyclosporin A (CsA) on the
in vivo humoral immune response against the non-MHC endothelial antigen that is present on the renal capillary and venous endothelium was tested in a rat model. Male MAXX rats were immunized using pooled spleen and lymph node cells from MHC-identical Brown Norway rats to induce the endothelial antibody response. The animals were treated with different doses of CsA for different periods and it was found that CsA suppressed the response completely and irreversibly when administered in a dose of 15 mg/kg/day with a minimum duration of therapy for 2 weeks. Animals that received a lower dose (10 mg/kg/day) or 15 mg/kg/day for 1 week, did show an initial response but failed to respond after repeated immunizations. The results show that CsA suppresses the humoral response to non-MHC alloantigens. Furthermore, a state of nonresponsiveness appears to be induced with doses which are not effective in suppressing the initial antibody response.</abstract><cop>San Diego, CA</cop><cop>New York, NY</cop><cop>Boston</cop><pub>Elsevier Inc</pub><pmid>3891176</pmid><doi>10.1016/0090-1229(85)90127-8</doi><tpages>5</tpages></addata></record> |
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| ispartof | Clinical immunology and immunopathology, 1985-01, Vol.36 (2), p.249-253 |
| issn | 0090-1229 1090-2341 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Antibody Formation - drug effects Biological and medical sciences Blood Vessels - immunology Cyclosporins - pharmacology Endothelium - immunology Immunomodulators Isoantigens - immunology Kidney - blood supply Kidney Transplantation Male Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred BN Transplantation Immunology - drug effects |
| title | Effect of cyclosporin A on the non-MHC endothelial antibody response in the rat |
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