Enhanced Secretion of Endothelin by Endothelial Cells in Response to Hemoglobin

Confluent cultures of bovine aortic endothelium in serum-free medium were exposed to increasing concentrations (10-6-10-4 M) of freshly prepared erythrocyte lysates (primarily hemoglobin). Hemoglobin increased endothelin-1 secretion into the medium in a dose-dependent manner after 24 hours. The enha...

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Veröffentlicht in:	Neurologia medico-chirurgica 1993, Vol.33(11), pp.739-743
Hauptverfasser:	FUWA, Isao, MAYBERG, Marc, GADJUSEK, Corinne, HARADA, Tsutomu, LUO, Zhengyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle Cells, Cultured endothelial cell endothelin Endothelins - metabolism Endothelium, Vascular - metabolism hemoglobin Hemoglobins - physiology Humans Oxyhemoglobins - physiology subarachnoid hemorrhage vasospasm
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