Erythrocyte membrane sodium-potassium and magnesium ATPase in primary affective disorder
Erythrocyte membrane Mg2+ ATPase and Na+-K+ ATPase were measured in patients with affective disorder, their well relatives, and normal controls during euthymic moods. On the average, the Mg2+ ATPase activity was high in subjects belonging to affective disorder families. However, the difference betwe...
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| Veröffentlicht in: | Biological psychiatry (1969) 1985-07, Vol.20 (7), p.734-740 |
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| container_title | Biological psychiatry (1969) |
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| creator | THAKAR, J. H LAPIERRE, Y. D WATERS, B. G |
| description | Erythrocyte membrane Mg2+ ATPase and Na+-K+ ATPase were measured in patients with affective disorder, their well relatives, and normal controls during euthymic moods. On the average, the Mg2+ ATPase activity was high in subjects belonging to affective disorder families. However, the difference between normal and affective disordered individuals was not statistically significant. Only the well individuals from affective disorder pedigrees as a group had significantly higher than normal Mg2+ ATPase activity (p less than 0.05). The Na+-K+ ATPase activity was similar for all the groups, including normal, bipolar manic-depressive (with or without lithium), unipolar depressive, and well individuals. Lithium treatment did not seem to have any effect on Mg2+ ATPase. Even though the values of Na+-K+ ATPase in the lithium-treated group were high, it is not certain that this was due to lithium per se. |
| doi_str_mv | 10.1016/0006-3223(85)90152-0 |
| format | Article |
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Even though the values of Na+-K+ ATPase in the lithium-treated group were high, it is not certain that this was due to lithium per se.</description><identifier>ISSN: 0006-3223</identifier><identifier>DOI: 10.1016/0006-3223(85)90152-0</identifier><identifier>PMID: 2988655</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Science</publisher><subject>Adenosine Triphosphatases - blood ; Biological and medical sciences ; Bipolar Disorder - drug therapy ; Bipolar Disorder - enzymology ; Bipolar Disorder - genetics ; Ca(2+) Mg(2+)-ATPase ; Depressive Disorder - enzymology ; Erythrocyte Membrane - enzymology ; Humans ; Lithium - therapeutic use ; Medical sciences ; Mental Disorders - enzymology ; Miscellaneous ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. 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G</creatorcontrib><title>Erythrocyte membrane sodium-potassium and magnesium ATPase in primary affective disorder</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Erythrocyte membrane Mg2+ ATPase and Na+-K+ ATPase were measured in patients with affective disorder, their well relatives, and normal controls during euthymic moods. On the average, the Mg2+ ATPase activity was high in subjects belonging to affective disorder families. However, the difference between normal and affective disordered individuals was not statistically significant. Only the well individuals from affective disorder pedigrees as a group had significantly higher than normal Mg2+ ATPase activity (p less than 0.05). The Na+-K+ ATPase activity was similar for all the groups, including normal, bipolar manic-depressive (with or without lithium), unipolar depressive, and well individuals. Lithium treatment did not seem to have any effect on Mg2+ ATPase. Even though the values of Na+-K+ ATPase in the lithium-treated group were high, it is not certain that this was due to lithium per se.</description><subject>Adenosine Triphosphatases - blood</subject><subject>Biological and medical sciences</subject><subject>Bipolar Disorder - drug therapy</subject><subject>Bipolar Disorder - enzymology</subject><subject>Bipolar Disorder - genetics</subject><subject>Ca(2+) Mg(2+)-ATPase</subject><subject>Depressive Disorder - enzymology</subject><subject>Erythrocyte Membrane - enzymology</subject><subject>Humans</subject><subject>Lithium - therapeutic use</subject><subject>Medical sciences</subject><subject>Mental Disorders - enzymology</subject><subject>Miscellaneous</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p167t-343e4f9eb2f262c29085ae8440b124c9b942a9f15957c24f91e2e5e6929547be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adenosine Triphosphatases - blood</topic><topic>Biological and medical sciences</topic><topic>Bipolar Disorder - drug therapy</topic><topic>Bipolar Disorder - enzymology</topic><topic>Bipolar Disorder - genetics</topic><topic>Ca(2+) Mg(2+)-ATPase</topic><topic>Depressive Disorder - enzymology</topic><topic>Erythrocyte Membrane - enzymology</topic><topic>Humans</topic><topic>Lithium - therapeutic use</topic><topic>Medical sciences</topic><topic>Mental Disorders - enzymology</topic><topic>Miscellaneous</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Sodium-Potassium-Exchanging ATPase - blood</topic><topic>Techniques and methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>THAKAR, J. H</creatorcontrib><creatorcontrib>LAPIERRE, Y. D</creatorcontrib><creatorcontrib>WATERS, B. G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>THAKAR, J. H</au><au>LAPIERRE, Y. D</au><au>WATERS, B. G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Erythrocyte membrane sodium-potassium and magnesium ATPase in primary affective disorder</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>1985-07</date><risdate>1985</risdate><volume>20</volume><issue>7</issue><spage>734</spage><epage>740</epage><pages>734-740</pages><issn>0006-3223</issn><coden>BIPCBF</coden><abstract>Erythrocyte membrane Mg2+ ATPase and Na+-K+ ATPase were measured in patients with affective disorder, their well relatives, and normal controls during euthymic moods. On the average, the Mg2+ ATPase activity was high in subjects belonging to affective disorder families. However, the difference between normal and affective disordered individuals was not statistically significant. Only the well individuals from affective disorder pedigrees as a group had significantly higher than normal Mg2+ ATPase activity (p less than 0.05). The Na+-K+ ATPase activity was similar for all the groups, including normal, bipolar manic-depressive (with or without lithium), unipolar depressive, and well individuals. Lithium treatment did not seem to have any effect on Mg2+ ATPase. Even though the values of Na+-K+ ATPase in the lithium-treated group were high, it is not certain that this was due to lithium per se.</abstract><cop>New York, NY</cop><pub>Elsevier Science</pub><pmid>2988655</pmid><doi>10.1016/0006-3223(85)90152-0</doi><tpages>7</tpages></addata></record> |
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| subjects | Adenosine Triphosphatases - blood Biological and medical sciences Bipolar Disorder - drug therapy Bipolar Disorder - enzymology Bipolar Disorder - genetics Ca(2+) Mg(2+)-ATPase Depressive Disorder - enzymology Erythrocyte Membrane - enzymology Humans Lithium - therapeutic use Medical sciences Mental Disorders - enzymology Miscellaneous Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Sodium-Potassium-Exchanging ATPase - blood Techniques and methods |
| title | Erythrocyte membrane sodium-potassium and magnesium ATPase in primary affective disorder |
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