Insertion of a foreign nucleotide sequence into mitochondrial DNA causes senescence in Neurospora intermedia
The kalilo variants of Neurospora contain a cytoplasmic genetic factor that causes senescence. This factor is a 9.0 kb transposable element (kalDNA) that lacks nucleotide sequence homology with mtDNA and is inserted into the mitochondrial chromosome, often at sites located within the open reading fr...
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| Veröffentlicht in: | Cell 1985-07, Vol.41 (3), p.877-884 |
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| container_title | Cell |
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| creator | Bertrand, H Chan, B S Griffiths, A J |
| description | The kalilo variants of Neurospora contain a cytoplasmic genetic factor that causes senescence. This factor is a 9.0 kb transposable element (kalDNA) that lacks nucleotide sequence homology with mtDNA and is inserted into the mitochondrial chromosome, often at sites located within the open reading frame in the intron-DNA of the mitochondrial 25S-rRNA gene. Genomes containing the "foreign" DNA insert accumulate during growth, and death occurs as the cells become deficient in functional large and small subunits of mitochondrial ribosomes. The kalDNA transposon may be an "activator" element that causes breaks in mtDNA. Nonsenescing [+] strains of Neurospora do not contain kalDNA. |
| doi_str_mv | 10.1016/S0092-8674(85)80068-4 |
| format | Article |
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This factor is a 9.0 kb transposable element (kalDNA) that lacks nucleotide sequence homology with mtDNA and is inserted into the mitochondrial chromosome, often at sites located within the open reading frame in the intron-DNA of the mitochondrial 25S-rRNA gene. Genomes containing the "foreign" DNA insert accumulate during growth, and death occurs as the cells become deficient in functional large and small subunits of mitochondrial ribosomes. The kalDNA transposon may be an "activator" element that causes breaks in mtDNA. 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| subjects | Base Sequence DNA Transposable Elements DNA, Fungal - genetics DNA, Mitochondrial - genetics Neurospora - genetics Neurospora - physiology Recombination, Genetic RNA - genetics RNA, Fungal - genetics RNA, Mitochondrial RNA, Ribosomal - genetics Species Specificity |
| title | Insertion of a foreign nucleotide sequence into mitochondrial DNA causes senescence in Neurospora intermedia |
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