The effect of metabolic acidosis on vitamin D metabolites and bone histology in uremic rats
Biochemical data and skeletal histomorphometric measurements are presented for normal rats and for two groups of rats rendered uremic by partial nephrectomy. In one of these groups chronic acidosis was induced by the oral administration of hydrochloric acid. Uremic animals had higher urine calcium e...
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| Veröffentlicht in: | Calcified tissue international 1985-03, Vol.37 (2), p.158-164 |
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| creator | Chan, Y L Savdie, E Mason, R S Posen, S |
| description | Biochemical data and skeletal histomorphometric measurements are presented for normal rats and for two groups of rats rendered uremic by partial nephrectomy. In one of these groups chronic acidosis was induced by the oral administration of hydrochloric acid. Uremic animals had higher urine calcium excretion rates and lower serum concentrations of vitamin D metabolites than normal rats. Chronic acid loading of uremic rats resulted in hypercalcemia, elevated serum parathyroid hormone concentrations, and a significant loss of trabecular bone in addition to the above changes. greater osteoclast densities and higher resorption surfaces wee seen in the uremic acidotic animals than in the other two groups. The acidotic uremic state induced more potent changes in calcium metabolism and bone structure than uremia alone. |
| doi_str_mv | 10.1007/bf02554835 |
| format | Article |
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In one of these groups chronic acidosis was induced by the oral administration of hydrochloric acid. Uremic animals had higher urine calcium excretion rates and lower serum concentrations of vitamin D metabolites than normal rats. Chronic acid loading of uremic rats resulted in hypercalcemia, elevated serum parathyroid hormone concentrations, and a significant loss of trabecular bone in addition to the above changes. greater osteoclast densities and higher resorption surfaces wee seen in the uremic acidotic animals than in the other two groups. The acidotic uremic state induced more potent changes in calcium metabolism and bone structure than uremia alone.</description><identifier>ISSN: 0171-967X</identifier><identifier>EISSN: 1432-0827</identifier><identifier>DOI: 10.1007/bf02554835</identifier><identifier>PMID: 3924372</identifier><language>eng</language><publisher>United States</publisher><subject>Acidosis - complications ; Acidosis - metabolism ; Acidosis - pathology ; Animals ; Bicarbonates - blood ; Blood ; Bone and Bones - pathology ; Calcium - metabolism ; Calcium - urine ; Creatinine - blood ; Hydrochloric Acid ; Hydrogen-Ion Concentration ; Male ; Rats ; Uremia - complications ; Uremia - metabolism ; Uremia - pathology ; Vitamin D - blood ; Vitamin D - metabolism</subject><ispartof>Calcified tissue international, 1985-03, Vol.37 (2), p.158-164</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-6417f5ab3b953ca074035b6ea2a0660ab59d5fbee42c227f3cc33fa1dd830c733</citedby><cites>FETCH-LOGICAL-c377t-6417f5ab3b953ca074035b6ea2a0660ab59d5fbee42c227f3cc33fa1dd830c733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27925,27926</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3924372$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chan, Y L</creatorcontrib><creatorcontrib>Savdie, E</creatorcontrib><creatorcontrib>Mason, R S</creatorcontrib><creatorcontrib>Posen, S</creatorcontrib><title>The effect of metabolic acidosis on vitamin D metabolites and bone histology in uremic rats</title><title>Calcified tissue international</title><addtitle>Calcif Tissue Int</addtitle><description>Biochemical data and skeletal histomorphometric measurements are presented for normal rats and for two groups of rats rendered uremic by partial nephrectomy. 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The acidotic uremic state induced more potent changes in calcium metabolism and bone structure than uremia alone.</description><subject>Acidosis - complications</subject><subject>Acidosis - metabolism</subject><subject>Acidosis - pathology</subject><subject>Animals</subject><subject>Bicarbonates - blood</subject><subject>Blood</subject><subject>Bone and Bones - pathology</subject><subject>Calcium - metabolism</subject><subject>Calcium - urine</subject><subject>Creatinine - blood</subject><subject>Hydrochloric Acid</subject><subject>Hydrogen-Ion Concentration</subject><subject>Male</subject><subject>Rats</subject><subject>Uremia - complications</subject><subject>Uremia - metabolism</subject><subject>Uremia - pathology</subject><subject>Vitamin D - blood</subject><subject>Vitamin D - metabolism</subject><issn>0171-967X</issn><issn>1432-0827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kL9LAzEcxYMotVYXdyGTg3Ca32lHrVaFgksFweFIct_YyN2lXnJC_3tPWp3e8D7vDR-Ezim5poToG-sJk1JMuTxAYyo4K8iU6UM0JlTTYqb02zE6SemTECqUUiM04jMmuGZj9L5aAwbvwWUcPW4gGxvr4LBxoYopJBxb_B2yaUKL7__7DAmbtsI2toDXIeVYx48tHpi-g2aYdyanU3TkTZ3gbJ8T9Lp4WM2fiuXL4_P8dlk4rnUulKDaS2O5nUnuDNGCcGkVGGaIUsRYOauktwCCOca0585x7g2tqiknTnM-QZe7300Xv3pIuWxCclDXpoXYp1IrKiUTYgCvdqDrYkod-HLThcZ025KS8tdkebf4MznAF_vX3jZQ_aN7dfwHOpVuQA</recordid><startdate>198503</startdate><enddate>198503</enddate><creator>Chan, Y L</creator><creator>Savdie, E</creator><creator>Mason, R S</creator><creator>Posen, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198503</creationdate><title>The effect of metabolic acidosis on vitamin D metabolites and bone histology in uremic rats</title><author>Chan, Y L ; Savdie, E ; Mason, R S ; Posen, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-6417f5ab3b953ca074035b6ea2a0660ab59d5fbee42c227f3cc33fa1dd830c733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Acidosis - complications</topic><topic>Acidosis - metabolism</topic><topic>Acidosis - pathology</topic><topic>Animals</topic><topic>Bicarbonates - blood</topic><topic>Blood</topic><topic>Bone and Bones - pathology</topic><topic>Calcium - metabolism</topic><topic>Calcium - urine</topic><topic>Creatinine - blood</topic><topic>Hydrochloric Acid</topic><topic>Hydrogen-Ion Concentration</topic><topic>Male</topic><topic>Rats</topic><topic>Uremia - complications</topic><topic>Uremia - metabolism</topic><topic>Uremia - pathology</topic><topic>Vitamin D - blood</topic><topic>Vitamin D - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chan, Y L</creatorcontrib><creatorcontrib>Savdie, E</creatorcontrib><creatorcontrib>Mason, R S</creatorcontrib><creatorcontrib>Posen, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Calcified tissue international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chan, Y L</au><au>Savdie, E</au><au>Mason, R S</au><au>Posen, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of metabolic acidosis on vitamin D metabolites and bone histology in uremic rats</atitle><jtitle>Calcified tissue international</jtitle><addtitle>Calcif Tissue Int</addtitle><date>1985-03</date><risdate>1985</risdate><volume>37</volume><issue>2</issue><spage>158</spage><epage>164</epage><pages>158-164</pages><issn>0171-967X</issn><eissn>1432-0827</eissn><abstract>Biochemical data and skeletal histomorphometric measurements are presented for normal rats and for two groups of rats rendered uremic by partial nephrectomy. In one of these groups chronic acidosis was induced by the oral administration of hydrochloric acid. Uremic animals had higher urine calcium excretion rates and lower serum concentrations of vitamin D metabolites than normal rats. Chronic acid loading of uremic rats resulted in hypercalcemia, elevated serum parathyroid hormone concentrations, and a significant loss of trabecular bone in addition to the above changes. greater osteoclast densities and higher resorption surfaces wee seen in the uremic acidotic animals than in the other two groups. The acidotic uremic state induced more potent changes in calcium metabolism and bone structure than uremia alone.</abstract><cop>United States</cop><pmid>3924372</pmid><doi>10.1007/bf02554835</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0171-967X |
| ispartof | Calcified tissue international, 1985-03, Vol.37 (2), p.158-164 |
| issn | 0171-967X 1432-0827 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Acidosis - complications Acidosis - metabolism Acidosis - pathology Animals Bicarbonates - blood Blood Bone and Bones - pathology Calcium - metabolism Calcium - urine Creatinine - blood Hydrochloric Acid Hydrogen-Ion Concentration Male Rats Uremia - complications Uremia - metabolism Uremia - pathology Vitamin D - blood Vitamin D - metabolism |
| title | The effect of metabolic acidosis on vitamin D metabolites and bone histology in uremic rats |
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