Restoration of gap-junctional intercellular communication in a communication-deficient rat liver cell mutant by transfection with connexin 43 cDNA

To study the biochemical basis of gap‐junctional intercellular communication (GJIC) and its role in tumorigenesis, a mammalian cell expression vector carrying both a rat connexin 43 (Cx43) cDNA and an amplifiable dihydrofolate reductase (DHFR) gene was transfected into the GJIC‐deficient rat liver m...

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Veröffentlicht in:	Molecular carcinogenesis 1993, Vol.8 (4), p.234-244
Hauptverfasser:	Jou, Yuh-Shan, Matesic, Diane, Dupont, Emmanuel, Lu, Shu-Chen, Rupp, Heather L., Madhukar, Burra V., Oh, Saw Yin, Trosko, James E., Chang, Chia-Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Northern Blotting, Southern Blotting, Western Cell Communication - physiology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Connexin 43 - genetics Connexin 43 - metabolism DNA, Complementary - genetics Fundamental and applied biological sciences. Psychology Gap Junctions - physiology Gene amplification Gene Amplification - genetics Gene Expression - genetics Liver - cytology Liver - physiology Liver Neoplasms, Experimental - etiology Liver Neoplasms, Experimental - genetics Methotrexate - pharmacology Molecular and cellular biology Mutation - genetics Phosphorylation posttranslational phosphorylation Protein Processing, Post-Translational Rats Rats, Inbred F344 Transfection
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