Characterization of Putative Glomerular Receptors for Angiotensin II in the Rainbow Trout Oncorhynchus mykiss Using the Antagonists Losartan, PD 123177, and Saralasin

Isolated glomeruli from the rainbow trout Oncorhynchus mykiss have been examined for the presence of receptors specific for angiotensin II (AII). Specific binding of 125I-Asp1Val5-AII was saturable, plateaued after 20 min, and increased with glomerular protein. Saralasin (Sar1Val5Ala8-AII), a nonsel...

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Veröffentlicht in:	General and comparative endocrinology 1993-10, Vol.92 (1), p.123-131
Hauptverfasser:	Cobb, Christopher S., Brown, J.Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Angiotensin II - metabolism Angiotensin Receptor Antagonists Animals Biological and medical sciences Biphenyl Compounds - pharmacology Cell receptors Cell structures and functions Freshwater Fundamental and applied biological sciences. Psychology Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Imidazoles - pharmacology Iodine Radioisotopes Kidney Glomerulus - metabolism Kinetics Losartan Molecular and cellular biology Oncorhynchus mykiss Oncorhynchus mykiss - metabolism Pyridines - pharmacology Receptors, Angiotensin - analysis Receptors, Angiotensin - metabolism Saralasin - pharmacology Tetrazoles - pharmacology
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