Relaxation by calcitonin gene-related peptide may involve activation of K + channels in the human uterine artery

The vasodilatory role of calcitonin gene-related peptide in activating K + channels was examined in isolated, suffused human uterine arteries. Calcitonin gene-related peptide produced a concentration-dependent relaxation of norepinephrine (1 μM)-induced contractions. Calcitonin gene-related peptide...

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Veröffentlicht in:	European journal of pharmacology 1993-10, Vol.242 (3), p.255-261
Hauptverfasser:	Nelson, Sharon H., Suresh, Maya S., Dehring, Deborah J., Johnson, Rebecca L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - pharmacology Adult Arteries - drug effects Biological and medical sciences Blood vessels and receptors Calcitonin Gene-Related Peptide - antagonists & inhibitors Calcitonin Gene-Related Peptide - pharmacology CGRP (calcitonin gene-related peptide) Female Fundamental and applied biological sciences. Psychology Glybenclamide Glyburide - pharmacology Guanidines - antagonists & inhibitors Guanidines - pharmacology Humans In Vitro Techniques K + channels Pinacidil Potassium Channel Blockers Potassium Channels - drug effects Pregnancy Tetraethylammonium Tetraethylammonium Compounds - pharmacology Uterine artery (human) Uterus - blood supply Vasodilator Agents - pharmacology Vertebrates: cardiovascular system
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