Enhancement of the horseradish peroxidase-catalyzed chemiluminescent oxidation of cyclic diacyl hydrazides by 6-hydroxybenzothiazoles
6-Hydroxybenzothiazole, 2-cyano-6-hydroxybenzothiazole, and 2-(6-hydroxy-2-benzothiazolyl)thiazole-4-carboxylic acid (dehydroluciferin) dramatically enhance light emission from the horseradish peroxidase conjugate catalyzed oxidation of luminol, isoluminol, N-(6-aminobutyl)- N-ethyl isoluminol, and...
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| Veröffentlicht in: | Analytical biochemistry 1985-02, Vol.145 (1), p.96-100 |
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| container_title | Analytical biochemistry |
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| creator | Thorpe, Gary H.G. Kricka, Larry J. Gillespie, Eileen Moseley, Susan Amess, Robert Baggett, Neil Whitehead, Thomas P. |
| description | 6-Hydroxybenzothiazole, 2-cyano-6-hydroxybenzothiazole, and 2-(6-hydroxy-2-benzothiazolyl)thiazole-4-carboxylic acid (dehydroluciferin) dramatically enhance light emission from the horseradish peroxidase conjugate catalyzed oxidation of luminol, isoluminol,
N-(6-aminobutyl)-
N-ethyl isoluminol, and 7-dimethylaminonaphthalene-1,2-dicarboxylic acid hydrazide by either peroxide or perborate. Light emission is enhanced by up to 1000-fold, which is an improvement over the enhancement previously observed using firefly luciferin (4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)thiazole-4-carboxylic acid). Enhancement is influenced by enhancer concentration and pH. Spectral scans of light emitted in enhanced and unenhanced reactions are similar, suggesting that aminophthalate products, and not the enhancers, are the emitters. |
| doi_str_mv | 10.1016/0003-2697(85)90332-X |
| format | Article |
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N-(6-aminobutyl)-
N-ethyl isoluminol, and 7-dimethylaminonaphthalene-1,2-dicarboxylic acid hydrazide by either peroxide or perborate. Light emission is enhanced by up to 1000-fold, which is an improvement over the enhancement previously observed using firefly luciferin (4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)thiazole-4-carboxylic acid). Enhancement is influenced by enhancer concentration and pH. Spectral scans of light emitted in enhanced and unenhanced reactions are similar, suggesting that aminophthalate products, and not the enhancers, are the emitters.</description><identifier>ISSN: 0003-2697</identifier><identifier>EISSN: 1096-0309</identifier><identifier>DOI: 10.1016/0003-2697(85)90332-X</identifier><identifier>PMID: 4003766</identifier><identifier>CODEN: ANBCA2</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>6-hydroxybenzothiazoles ; Analytical biochemistry: general aspects, technics, instrumentation ; Analytical, structural and metabolic biochemistry ; Armoracia lapathifolia ; Biological and medical sciences ; Catalysis ; chemiluminescence ; enhanced chemiluminescence ; firefly luciferin ; Fundamental and applied biological sciences. Psychology ; Horseradish Peroxidase - metabolism ; horseradish peroxidase conjugates ; Hydrazines - chemical synthesis ; Hydrogen-Ion Concentration ; Indicators and Reagents - chemical synthesis ; isoluminol ; Luminescent Measurements ; luminol ; Oxidation-Reduction ; peroxidase ; Peroxidases - metabolism ; Spectrometry, Fluorescence ; Thiazoles - chemical synthesis</subject><ispartof>Analytical biochemistry, 1985-02, Vol.145 (1), p.96-100</ispartof><rights>1985</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-5997ef7e6c8268145e3e110e6bd87b1756b15801cbec1a4481acb454e290d4a03</citedby><cites>FETCH-LOGICAL-c398t-5997ef7e6c8268145e3e110e6bd87b1756b15801cbec1a4481acb454e290d4a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0003-2697(85)90332-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8536570$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4003766$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thorpe, Gary H.G.</creatorcontrib><creatorcontrib>Kricka, Larry J.</creatorcontrib><creatorcontrib>Gillespie, Eileen</creatorcontrib><creatorcontrib>Moseley, Susan</creatorcontrib><creatorcontrib>Amess, Robert</creatorcontrib><creatorcontrib>Baggett, Neil</creatorcontrib><creatorcontrib>Whitehead, Thomas P.</creatorcontrib><title>Enhancement of the horseradish peroxidase-catalyzed chemiluminescent oxidation of cyclic diacyl hydrazides by 6-hydroxybenzothiazoles</title><title>Analytical biochemistry</title><addtitle>Anal Biochem</addtitle><description>6-Hydroxybenzothiazole, 2-cyano-6-hydroxybenzothiazole, and 2-(6-hydroxy-2-benzothiazolyl)thiazole-4-carboxylic acid (dehydroluciferin) dramatically enhance light emission from the horseradish peroxidase conjugate catalyzed oxidation of luminol, isoluminol,
N-(6-aminobutyl)-
N-ethyl isoluminol, and 7-dimethylaminonaphthalene-1,2-dicarboxylic acid hydrazide by either peroxide or perborate. Light emission is enhanced by up to 1000-fold, which is an improvement over the enhancement previously observed using firefly luciferin (4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)thiazole-4-carboxylic acid). Enhancement is influenced by enhancer concentration and pH. Spectral scans of light emitted in enhanced and unenhanced reactions are similar, suggesting that aminophthalate products, and not the enhancers, are the emitters.</description><subject>6-hydroxybenzothiazoles</subject><subject>Analytical biochemistry: general aspects, technics, instrumentation</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Armoracia lapathifolia</subject><subject>Biological and medical sciences</subject><subject>Catalysis</subject><subject>chemiluminescence</subject><subject>enhanced chemiluminescence</subject><subject>firefly luciferin</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Horseradish Peroxidase - metabolism</subject><subject>horseradish peroxidase conjugates</subject><subject>Hydrazines - chemical synthesis</subject><subject>Hydrogen-Ion Concentration</subject><subject>Indicators and Reagents - chemical synthesis</subject><subject>isoluminol</subject><subject>Luminescent Measurements</subject><subject>luminol</subject><subject>Oxidation-Reduction</subject><subject>peroxidase</subject><subject>Peroxidases - metabolism</subject><subject>Spectrometry, Fluorescence</subject><subject>Thiazoles - chemical synthesis</subject><issn>0003-2697</issn><issn>1096-0309</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFDEYx4ModW39Bgo5iOhhbDJ5nYsgpVqh4EWht5BJnmEimcmazJbO3v3eznSXPdpTCP-XPE9-CL2h5BMlVF4SQlhVy0Z90OJjQxirq7tnaENJIyvCSPMcbU6Wl-hVKb8JoZQLeYbO-CIoKTfo7_XY29HBAOOEU4enHnCfcoFsfSg93kJOD8HbApWzk43zHjx2PQwh7oYwQnGPwdUyhTSuFW52MTjsg3VzxP3ss90HDwW3M5bVek8PcwvjPk19sPsUoVygF52NBV4fz3P06-v1z6ub6vbHt-9XX24rxxo9VaJpFHQKpNO11MsqwIBSArL1WrVUCdlSoQl1LThqOdfUupYLDnVDPLeEnaP3h95tTn92UCYzhGWDGO0IaVeMkpQrwcSTRsopqWu2NvKD0eVUSobObHMYbJ4NJWbFZFYGZmVgtDCPmMzdEnt77N-1A_hT6Mhl0d8ddVucjV1eGIVysmnBpFDr658PNlg-7T5ANsUFWHD6kMFNxqfw_zn-Af2UsXk</recordid><startdate>19850215</startdate><enddate>19850215</enddate><creator>Thorpe, Gary H.G.</creator><creator>Kricka, Larry J.</creator><creator>Gillespie, Eileen</creator><creator>Moseley, Susan</creator><creator>Amess, Robert</creator><creator>Baggett, Neil</creator><creator>Whitehead, Thomas P.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19850215</creationdate><title>Enhancement of the horseradish peroxidase-catalyzed chemiluminescent oxidation of cyclic diacyl hydrazides by 6-hydroxybenzothiazoles</title><author>Thorpe, Gary H.G. ; Kricka, Larry J. ; Gillespie, Eileen ; Moseley, Susan ; Amess, Robert ; Baggett, Neil ; Whitehead, Thomas P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-5997ef7e6c8268145e3e110e6bd87b1756b15801cbec1a4481acb454e290d4a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>6-hydroxybenzothiazoles</topic><topic>Analytical biochemistry: general aspects, technics, instrumentation</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Armoracia lapathifolia</topic><topic>Biological and medical sciences</topic><topic>Catalysis</topic><topic>chemiluminescence</topic><topic>enhanced chemiluminescence</topic><topic>firefly luciferin</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Horseradish Peroxidase - metabolism</topic><topic>horseradish peroxidase conjugates</topic><topic>Hydrazines - chemical synthesis</topic><topic>Hydrogen-Ion Concentration</topic><topic>Indicators and Reagents - chemical synthesis</topic><topic>isoluminol</topic><topic>Luminescent Measurements</topic><topic>luminol</topic><topic>Oxidation-Reduction</topic><topic>peroxidase</topic><topic>Peroxidases - metabolism</topic><topic>Spectrometry, Fluorescence</topic><topic>Thiazoles - chemical synthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thorpe, Gary H.G.</creatorcontrib><creatorcontrib>Kricka, Larry J.</creatorcontrib><creatorcontrib>Gillespie, Eileen</creatorcontrib><creatorcontrib>Moseley, Susan</creatorcontrib><creatorcontrib>Amess, Robert</creatorcontrib><creatorcontrib>Baggett, Neil</creatorcontrib><creatorcontrib>Whitehead, Thomas P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thorpe, Gary H.G.</au><au>Kricka, Larry J.</au><au>Gillespie, Eileen</au><au>Moseley, Susan</au><au>Amess, Robert</au><au>Baggett, Neil</au><au>Whitehead, Thomas P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhancement of the horseradish peroxidase-catalyzed chemiluminescent oxidation of cyclic diacyl hydrazides by 6-hydroxybenzothiazoles</atitle><jtitle>Analytical biochemistry</jtitle><addtitle>Anal Biochem</addtitle><date>1985-02-15</date><risdate>1985</risdate><volume>145</volume><issue>1</issue><spage>96</spage><epage>100</epage><pages>96-100</pages><issn>0003-2697</issn><eissn>1096-0309</eissn><coden>ANBCA2</coden><abstract>6-Hydroxybenzothiazole, 2-cyano-6-hydroxybenzothiazole, and 2-(6-hydroxy-2-benzothiazolyl)thiazole-4-carboxylic acid (dehydroluciferin) dramatically enhance light emission from the horseradish peroxidase conjugate catalyzed oxidation of luminol, isoluminol,
N-(6-aminobutyl)-
N-ethyl isoluminol, and 7-dimethylaminonaphthalene-1,2-dicarboxylic acid hydrazide by either peroxide or perborate. Light emission is enhanced by up to 1000-fold, which is an improvement over the enhancement previously observed using firefly luciferin (4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)thiazole-4-carboxylic acid). Enhancement is influenced by enhancer concentration and pH. Spectral scans of light emitted in enhanced and unenhanced reactions are similar, suggesting that aminophthalate products, and not the enhancers, are the emitters.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>4003766</pmid><doi>10.1016/0003-2697(85)90332-X</doi><tpages>5</tpages></addata></record> |
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| subjects | 6-hydroxybenzothiazoles Analytical biochemistry: general aspects, technics, instrumentation Analytical, structural and metabolic biochemistry Armoracia lapathifolia Biological and medical sciences Catalysis chemiluminescence enhanced chemiluminescence firefly luciferin Fundamental and applied biological sciences. Psychology Horseradish Peroxidase - metabolism horseradish peroxidase conjugates Hydrazines - chemical synthesis Hydrogen-Ion Concentration Indicators and Reagents - chemical synthesis isoluminol Luminescent Measurements luminol Oxidation-Reduction peroxidase Peroxidases - metabolism Spectrometry, Fluorescence Thiazoles - chemical synthesis |
| title | Enhancement of the horseradish peroxidase-catalyzed chemiluminescent oxidation of cyclic diacyl hydrazides by 6-hydroxybenzothiazoles |
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