Vitamin B-6 status indices are lower in pregnant than in nonpregnant women but urinary excretion of 4-pyridoxic acid does not differ
The cause of reduced plasma pyridoxal-5'-phosphate (PLP) concentration and the validity of plasma PLP concentration as a vitamin B-6 status indicator during pregnancy are not well understood. in this study, pregnant and nonpregnant women consumed a controlled diet for 5 d to exclude dietary int...
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| Veröffentlicht in: | The Journal of nutrition 1993-12, Vol.123 (12), p.2137-2141 |
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| creator | Trumbo, P.R Wang, J.W |
| description | The cause of reduced plasma pyridoxal-5'-phosphate (PLP) concentration and the validity of plasma PLP concentration as a vitamin B-6 status indicator during pregnancy are not well understood. in this study, pregnant and nonpregnant women consumed a controlled diet for 5 d to exclude dietary intake as a factor in altered vitamin B-6 metabolic utilization. Plasma PLP and pyridoxal (PL) concentrations were significantly lower and higher, respectively, and plasma PL+PLP concentration was significantly lower during pregnancy. When plasma PLP and PL concentrations were normalized based on plasma albumin concentration, the differences were less marked but were still significant. The erythrocyte aspartate aminotransferase activity coefficient was significantly greater in pregnant women which is a further indication of reduced vitamin B-6 concentrations in the blood. No difference was observed in the urinary excretion of 4-pyridoxic acid between the pregnant and nonpregnant women. Results of this study demonstrate that vitamin B-6 status indices are lower during pregnancy without differences in the urinary excretion of 4-pyridoxic acid |
| format | Article |
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Plasma PLP and pyridoxal (PL) concentrations were significantly lower and higher, respectively, and plasma PL+PLP concentration was significantly lower during pregnancy. When plasma PLP and PL concentrations were normalized based on plasma albumin concentration, the differences were less marked but were still significant. The erythrocyte aspartate aminotransferase activity coefficient was significantly greater in pregnant women which is a further indication of reduced vitamin B-6 concentrations in the blood. No difference was observed in the urinary excretion of 4-pyridoxic acid between the pregnant and nonpregnant women. Results of this study demonstrate that vitamin B-6 status indices are lower during pregnancy without differences in the urinary excretion of 4-pyridoxic acid</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>PMID: 8263608</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Nutritional Sciences</publisher><subject>Adult ; Alkaline Phosphatase - blood ; Aspartate Aminotransferases - biosynthesis ; Aspartate Aminotransferases - blood ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; COENZIMAS ; COENZYME ; DISPONIBILIDAD DE NUTRIENTES ; DISPONIBILITE D'ELEMENT NUTRITIF ; Erythrocytes - enzymology ; ESTADO NUTRICIONAL ; ETAT NUTRITIONNEL ; European Continental Ancestry Group ; EXCRECION ; EXCRETION ; Female ; FEMME ; FOSFATASA ALCALINA ; Fundamental and applied biological sciences. Psychology ; GESTACION ; GESTATION ; Humans ; Mother. Fetoplacental unit. Mammary gland. Milk ; MUJERES ; ORGANISME INDICATEUR ; ORGANISMOS INDICADORES ; ORINA ; PHOSPHATASE ALCALINE ; PIRIDINAS ; PIRIDOXINA ; PLASMA SANGUIN ; PLASMA SANGUINEO ; Pregnancy - blood ; Pregnancy Trimester, Third ; Pregnancy. Parturition. Lactation ; PYRIDINE ; Pyridoxal - blood ; Pyridoxal Phosphate - blood ; Pyridoxic Acid - urine ; PYRIDOXINE ; Pyridoxine - blood ; Serum Albumin - analysis ; Spectrophotometry ; URINE ; Vertebrates: reproduction</subject><ispartof>The Journal of nutrition, 1993-12, Vol.123 (12), p.2137-2141</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3934165$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8263608$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trumbo, P.R</creatorcontrib><creatorcontrib>Wang, J.W</creatorcontrib><title>Vitamin B-6 status indices are lower in pregnant than in nonpregnant women but urinary excretion of 4-pyridoxic acid does not differ</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>The cause of reduced plasma pyridoxal-5'-phosphate (PLP) concentration and the validity of plasma PLP concentration as a vitamin B-6 status indicator during pregnancy are not well understood. in this study, pregnant and nonpregnant women consumed a controlled diet for 5 d to exclude dietary intake as a factor in altered vitamin B-6 metabolic utilization. Plasma PLP and pyridoxal (PL) concentrations were significantly lower and higher, respectively, and plasma PL+PLP concentration was significantly lower during pregnancy. When plasma PLP and PL concentrations were normalized based on plasma albumin concentration, the differences were less marked but were still significant. The erythrocyte aspartate aminotransferase activity coefficient was significantly greater in pregnant women which is a further indication of reduced vitamin B-6 concentrations in the blood. No difference was observed in the urinary excretion of 4-pyridoxic acid between the pregnant and nonpregnant women. Results of this study demonstrate that vitamin B-6 status indices are lower during pregnancy without differences in the urinary excretion of 4-pyridoxic acid</description><subject>Adult</subject><subject>Alkaline Phosphatase - blood</subject><subject>Aspartate Aminotransferases - biosynthesis</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>COENZIMAS</subject><subject>COENZYME</subject><subject>DISPONIBILIDAD DE NUTRIENTES</subject><subject>DISPONIBILITE D'ELEMENT NUTRITIF</subject><subject>Erythrocytes - enzymology</subject><subject>ESTADO NUTRICIONAL</subject><subject>ETAT NUTRITIONNEL</subject><subject>European Continental Ancestry Group</subject><subject>EXCRECION</subject><subject>EXCRETION</subject><subject>Female</subject><subject>FEMME</subject><subject>FOSFATASA ALCALINA</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GESTACION</subject><subject>GESTATION</subject><subject>Humans</subject><subject>Mother. Fetoplacental unit. Mammary gland. Milk</subject><subject>MUJERES</subject><subject>ORGANISME INDICATEUR</subject><subject>ORGANISMOS INDICADORES</subject><subject>ORINA</subject><subject>PHOSPHATASE ALCALINE</subject><subject>PIRIDINAS</subject><subject>PIRIDOXINA</subject><subject>PLASMA SANGUIN</subject><subject>PLASMA SANGUINEO</subject><subject>Pregnancy - blood</subject><subject>Pregnancy Trimester, Third</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>PYRIDINE</subject><subject>Pyridoxal - blood</subject><subject>Pyridoxal Phosphate - blood</subject><subject>Pyridoxic Acid - urine</subject><subject>PYRIDOXINE</subject><subject>Pyridoxine - blood</subject><subject>Serum Albumin - analysis</subject><subject>Spectrophotometry</subject><subject>URINE</subject><subject>Vertebrates: reproduction</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLxDAUhYsoOj7-gCBkIe4KSZMmzVLFFwgudNyW2_RGI20yJimOe3-4lRlcXfjOx4Fzd4oFqwUrJaN0t1hQWlUlZ1IeFIcpfVBKmdDNfrHfVJJL2iyKn1eXYXSeXJWSpAx5SsT53hlMBCKSIXxhnAlZRXzz4DPJ7-D_gA_-n32FET3ppkym6DzEb4JrEzG74EmwRJSr7-j6sHaGgHE96cNc70MmvbMW43GxZ2FIeLK9R8Xy9ubl-r58fLp7uL58LC2TOpe657xSSohOC8W4qrXmqJluRM2tqRlnHe9kx-oKGqsYAgWsmDU9cit01fGj4mLTu4rhc8KU29Elg8MAHsOUWiWZUEKqWTzbilM3Yt-uohvnVe32bXN-vs0hGRhsBG9c-te45oLJetZON5qF0MJbnJXlsxY1VVzyX85if50</recordid><startdate>199312</startdate><enddate>199312</enddate><creator>Trumbo, P.R</creator><creator>Wang, J.W</creator><general>American Society for Nutritional Sciences</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199312</creationdate><title>Vitamin B-6 status indices are lower in pregnant than in nonpregnant women but urinary excretion of 4-pyridoxic acid does not differ</title><author>Trumbo, P.R ; Wang, J.W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f169t-9d3327744b9471375993e9198453fc5131b3b6b152a8f71ea0ae21fcde3f492b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Alkaline Phosphatase - blood</topic><topic>Aspartate Aminotransferases - biosynthesis</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>COENZIMAS</topic><topic>COENZYME</topic><topic>DISPONIBILIDAD DE NUTRIENTES</topic><topic>DISPONIBILITE D'ELEMENT NUTRITIF</topic><topic>Erythrocytes - enzymology</topic><topic>ESTADO NUTRICIONAL</topic><topic>ETAT NUTRITIONNEL</topic><topic>European Continental Ancestry Group</topic><topic>EXCRECION</topic><topic>EXCRETION</topic><topic>Female</topic><topic>FEMME</topic><topic>FOSFATASA ALCALINA</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GESTACION</topic><topic>GESTATION</topic><topic>Humans</topic><topic>Mother. Fetoplacental unit. Mammary gland. Milk</topic><topic>MUJERES</topic><topic>ORGANISME INDICATEUR</topic><topic>ORGANISMOS INDICADORES</topic><topic>ORINA</topic><topic>PHOSPHATASE ALCALINE</topic><topic>PIRIDINAS</topic><topic>PIRIDOXINA</topic><topic>PLASMA SANGUIN</topic><topic>PLASMA SANGUINEO</topic><topic>Pregnancy - blood</topic><topic>Pregnancy Trimester, Third</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>PYRIDINE</topic><topic>Pyridoxal - blood</topic><topic>Pyridoxal Phosphate - blood</topic><topic>Pyridoxic Acid - urine</topic><topic>PYRIDOXINE</topic><topic>Pyridoxine - blood</topic><topic>Serum Albumin - analysis</topic><topic>Spectrophotometry</topic><topic>URINE</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trumbo, P.R</creatorcontrib><creatorcontrib>Wang, J.W</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trumbo, P.R</au><au>Wang, J.W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin B-6 status indices are lower in pregnant than in nonpregnant women but urinary excretion of 4-pyridoxic acid does not differ</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1993-12</date><risdate>1993</risdate><volume>123</volume><issue>12</issue><spage>2137</spage><epage>2141</epage><pages>2137-2141</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>The cause of reduced plasma pyridoxal-5'-phosphate (PLP) concentration and the validity of plasma PLP concentration as a vitamin B-6 status indicator during pregnancy are not well understood. in this study, pregnant and nonpregnant women consumed a controlled diet for 5 d to exclude dietary intake as a factor in altered vitamin B-6 metabolic utilization. Plasma PLP and pyridoxal (PL) concentrations were significantly lower and higher, respectively, and plasma PL+PLP concentration was significantly lower during pregnancy. When plasma PLP and PL concentrations were normalized based on plasma albumin concentration, the differences were less marked but were still significant. The erythrocyte aspartate aminotransferase activity coefficient was significantly greater in pregnant women which is a further indication of reduced vitamin B-6 concentrations in the blood. No difference was observed in the urinary excretion of 4-pyridoxic acid between the pregnant and nonpregnant women. Results of this study demonstrate that vitamin B-6 status indices are lower during pregnancy without differences in the urinary excretion of 4-pyridoxic acid</abstract><cop>Bethesda, MD</cop><pub>American Society for Nutritional Sciences</pub><pmid>8263608</pmid><tpages>5</tpages></addata></record> |
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| subjects | Adult Alkaline Phosphatase - blood Aspartate Aminotransferases - biosynthesis Aspartate Aminotransferases - blood Biological and medical sciences Chromatography, High Pressure Liquid COENZIMAS COENZYME DISPONIBILIDAD DE NUTRIENTES DISPONIBILITE D'ELEMENT NUTRITIF Erythrocytes - enzymology ESTADO NUTRICIONAL ETAT NUTRITIONNEL European Continental Ancestry Group EXCRECION EXCRETION Female FEMME FOSFATASA ALCALINA Fundamental and applied biological sciences. Psychology GESTACION GESTATION Humans Mother. Fetoplacental unit. Mammary gland. Milk MUJERES ORGANISME INDICATEUR ORGANISMOS INDICADORES ORINA PHOSPHATASE ALCALINE PIRIDINAS PIRIDOXINA PLASMA SANGUIN PLASMA SANGUINEO Pregnancy - blood Pregnancy Trimester, Third Pregnancy. Parturition. Lactation PYRIDINE Pyridoxal - blood Pyridoxal Phosphate - blood Pyridoxic Acid - urine PYRIDOXINE Pyridoxine - blood Serum Albumin - analysis Spectrophotometry URINE Vertebrates: reproduction |
| title | Vitamin B-6 status indices are lower in pregnant than in nonpregnant women but urinary excretion of 4-pyridoxic acid does not differ |
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