Antiviral action of trehalose dimycolate against EMC virus: role of macrophages and interferon α/β
Preventive treatment of mice with trehalose 6,6′ dimycolate (TDM), an immunomodulator of bacterial origin, enhances their resistance to encephalomyocarditis (EMC) virus infection. The protective effect of TDM is totally abolished by the injection of silica particles in mice, demonstrating the role o...
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| Veröffentlicht in: | Antiviral research 1993-10, Vol.22 (2), p.201-213 |
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| creator | Guillemard, E. Geniteau-Legendre, M. Mabboux, B. Poilane, I. Kergot, R. Lemaire, G. Petit, J.F. Labarre, C. Quero, A.M. |
| description | Preventive treatment of mice with trehalose 6,6′ dimycolate (TDM), an immunomodulator of bacterial origin, enhances their resistance to encephalomyocarditis (EMC) virus infection. The protective effect of TDM is totally abolished by the injection of silica particles in mice, demonstrating the role of macrophages in the antiviral action of TDM. In vitro, peritoneal macrophages from mice treated with TDM (TDM-PM) exhibit an intrinsic antiviral activity against EMC virus, while resident peritoneal macrophages (RES-PM) are permissive to this virus. Greater amounts of interferon are detected in supernatants of cultures of TDM-PM than of RES-PM. Neutralization of interferon (IFN) by addition in vitro of anti-IFN α/β serum markedly reduces the antiviral activity of TDM-PM. These results indicate that interferon α/β is involved in the intrinsic anti-EMC virus activity of peritoneal macrophages from mice treated with TDM. |
| doi_str_mv | 10.1016/0166-3542(93)90096-2 |
| format | Article |
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The protective effect of TDM is totally abolished by the injection of silica particles in mice, demonstrating the role of macrophages in the antiviral action of TDM. In vitro, peritoneal macrophages from mice treated with TDM (TDM-PM) exhibit an intrinsic antiviral activity against EMC virus, while resident peritoneal macrophages (RES-PM) are permissive to this virus. Greater amounts of interferon are detected in supernatants of cultures of TDM-PM than of RES-PM. Neutralization of interferon (IFN) by addition in vitro of anti-IFN α/β serum markedly reduces the antiviral activity of TDM-PM. These results indicate that interferon α/β is involved in the intrinsic anti-EMC virus activity of peritoneal macrophages from mice treated with TDM.</description><identifier>ISSN: 0166-3542</identifier><identifier>EISSN: 1872-9096</identifier><identifier>DOI: 10.1016/0166-3542(93)90096-2</identifier><identifier>PMID: 7506511</identifier><identifier>CODEN: ARSRDR</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Biological and medical sciences ; Brain - drug effects ; Brain - microbiology ; Cardiovirus Infections - drug therapy ; Cardiovirus Infections - mortality ; Cells, Cultured ; Cord Factors - therapeutic use ; EMC virus ; Encephalomyocarditis virus ; Female ; Interferon ; Interferon-alpha - biosynthesis ; Interferon-alpha - immunology ; Interferon-alpha - pharmacology ; Interferon-beta - biosynthesis ; Interferon-beta - immunology ; Interferon-beta - pharmacology ; Interferons - biosynthesis ; Interferons - immunology ; Interferons - pharmacology ; Macrophage ; Macrophages, Peritoneal - cytology ; Macrophages, Peritoneal - metabolism ; Medical sciences ; Mice ; Pharmacology. 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The protective effect of TDM is totally abolished by the injection of silica particles in mice, demonstrating the role of macrophages in the antiviral action of TDM. In vitro, peritoneal macrophages from mice treated with TDM (TDM-PM) exhibit an intrinsic antiviral activity against EMC virus, while resident peritoneal macrophages (RES-PM) are permissive to this virus. Greater amounts of interferon are detected in supernatants of cultures of TDM-PM than of RES-PM. Neutralization of interferon (IFN) by addition in vitro of anti-IFN α/β serum markedly reduces the antiviral activity of TDM-PM. These results indicate that interferon α/β is involved in the intrinsic anti-EMC virus activity of peritoneal macrophages from mice treated with TDM.</description><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - microbiology</subject><subject>Cardiovirus Infections - drug therapy</subject><subject>Cardiovirus Infections - mortality</subject><subject>Cells, Cultured</subject><subject>Cord Factors - therapeutic use</subject><subject>EMC virus</subject><subject>Encephalomyocarditis virus</subject><subject>Female</subject><subject>Interferon</subject><subject>Interferon-alpha - biosynthesis</subject><subject>Interferon-alpha - immunology</subject><subject>Interferon-alpha - pharmacology</subject><subject>Interferon-beta - biosynthesis</subject><subject>Interferon-beta - immunology</subject><subject>Interferon-beta - pharmacology</subject><subject>Interferons - biosynthesis</subject><subject>Interferons - immunology</subject><subject>Interferons - pharmacology</subject><subject>Macrophage</subject><subject>Macrophages, Peritoneal - cytology</subject><subject>Macrophages, Peritoneal - metabolism</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pharmacology. Drug treatments</subject><subject>Silicon Dioxide - pharmacology</subject><subject>TDM</subject><issn>0166-3542</issn><issn>1872-9096</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFKHTEUhkOp2KvtG7SQRRFdTE0mM8nEhSAXtYKlm3YdMsmJRmYm1yRX8LH0QXwmM72Xu-wiHML5_p_Dh9BXSn5QQvlpebxibVMfS3YiCZG8qj-gBe1EXcny-4gWO-QTOkjpgRDChez20b5oCW8pXSB7MWX_5KMesDbZhwkHh3OEez2EBNj68dmEQWfA-k77KWV8-WuJS2CdznAMA8z8qE0Mq3t9BwnryWI_ZYgOYml7ezl9e_2M9pweEnzZzkP09-ryz_Jndfv7-mZ5cVsZ1vFcMdE72tpOSicF7bjjrJXGEUJ7WTcCmO6J7HpoqDC864wzvZEWBEgHtbSEHaKjTe8qhsc1pKxGnwwMg54grJMSnDatbOsCNhuw3J1SBKdW0Y86PitK1CxXzebUbE5Jpv7JVXPs27Z_3Y9gd6GtzbL_vt3rZPTgop6MTzuMiZYx3hTsfINBcfHkIapkPEwGrI9gsrLB__-Od3Jol4k</recordid><startdate>19931001</startdate><enddate>19931001</enddate><creator>Guillemard, E.</creator><creator>Geniteau-Legendre, M.</creator><creator>Mabboux, B.</creator><creator>Poilane, I.</creator><creator>Kergot, R.</creator><creator>Lemaire, G.</creator><creator>Petit, J.F.</creator><creator>Labarre, C.</creator><creator>Quero, A.M.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19931001</creationdate><title>Antiviral action of trehalose dimycolate against EMC virus: role of macrophages and interferon α/β</title><author>Guillemard, E. ; Geniteau-Legendre, M. ; Mabboux, B. ; Poilane, I. ; Kergot, R. ; Lemaire, G. ; Petit, J.F. ; Labarre, C. ; Quero, A.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-37bf15d899f97186f6359cf001b9247e3ab098be417c688cfcbc9de7e9fe29d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - microbiology</topic><topic>Cardiovirus Infections - drug therapy</topic><topic>Cardiovirus Infections - mortality</topic><topic>Cells, Cultured</topic><topic>Cord Factors - therapeutic use</topic><topic>EMC virus</topic><topic>Encephalomyocarditis virus</topic><topic>Female</topic><topic>Interferon</topic><topic>Interferon-alpha - biosynthesis</topic><topic>Interferon-alpha - immunology</topic><topic>Interferon-alpha - pharmacology</topic><topic>Interferon-beta - biosynthesis</topic><topic>Interferon-beta - immunology</topic><topic>Interferon-beta - pharmacology</topic><topic>Interferons - biosynthesis</topic><topic>Interferons - immunology</topic><topic>Interferons - pharmacology</topic><topic>Macrophage</topic><topic>Macrophages, Peritoneal - cytology</topic><topic>Macrophages, Peritoneal - metabolism</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Pharmacology. Drug treatments</topic><topic>Silicon Dioxide - pharmacology</topic><topic>TDM</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guillemard, E.</creatorcontrib><creatorcontrib>Geniteau-Legendre, M.</creatorcontrib><creatorcontrib>Mabboux, B.</creatorcontrib><creatorcontrib>Poilane, I.</creatorcontrib><creatorcontrib>Kergot, R.</creatorcontrib><creatorcontrib>Lemaire, G.</creatorcontrib><creatorcontrib>Petit, J.F.</creatorcontrib><creatorcontrib>Labarre, C.</creatorcontrib><creatorcontrib>Quero, A.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Antiviral research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guillemard, E.</au><au>Geniteau-Legendre, M.</au><au>Mabboux, B.</au><au>Poilane, I.</au><au>Kergot, R.</au><au>Lemaire, G.</au><au>Petit, J.F.</au><au>Labarre, C.</au><au>Quero, A.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiviral action of trehalose dimycolate against EMC virus: role of macrophages and interferon α/β</atitle><jtitle>Antiviral research</jtitle><addtitle>Antiviral Res</addtitle><date>1993-10-01</date><risdate>1993</risdate><volume>22</volume><issue>2</issue><spage>201</spage><epage>213</epage><pages>201-213</pages><issn>0166-3542</issn><eissn>1872-9096</eissn><coden>ARSRDR</coden><abstract>Preventive treatment of mice with trehalose 6,6′ dimycolate (TDM), an immunomodulator of bacterial origin, enhances their resistance to encephalomyocarditis (EMC) virus infection. The protective effect of TDM is totally abolished by the injection of silica particles in mice, demonstrating the role of macrophages in the antiviral action of TDM. In vitro, peritoneal macrophages from mice treated with TDM (TDM-PM) exhibit an intrinsic antiviral activity against EMC virus, while resident peritoneal macrophages (RES-PM) are permissive to this virus. Greater amounts of interferon are detected in supernatants of cultures of TDM-PM than of RES-PM. Neutralization of interferon (IFN) by addition in vitro of anti-IFN α/β serum markedly reduces the antiviral activity of TDM-PM. These results indicate that interferon α/β is involved in the intrinsic anti-EMC virus activity of peritoneal macrophages from mice treated with TDM.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>7506511</pmid><doi>10.1016/0166-3542(93)90096-2</doi><tpages>13</tpages></addata></record> |
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| subjects | Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Brain - drug effects Brain - microbiology Cardiovirus Infections - drug therapy Cardiovirus Infections - mortality Cells, Cultured Cord Factors - therapeutic use EMC virus Encephalomyocarditis virus Female Interferon Interferon-alpha - biosynthesis Interferon-alpha - immunology Interferon-alpha - pharmacology Interferon-beta - biosynthesis Interferon-beta - immunology Interferon-beta - pharmacology Interferons - biosynthesis Interferons - immunology Interferons - pharmacology Macrophage Macrophages, Peritoneal - cytology Macrophages, Peritoneal - metabolism Medical sciences Mice Pharmacology. Drug treatments Silicon Dioxide - pharmacology TDM |
| title | Antiviral action of trehalose dimycolate against EMC virus: role of macrophages and interferon α/β |
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