Reactivity of locally produced CSF antibodies in patients with neurosyphilis against antigens of Treponema pallidum
The reactivity and specificity of locally produced cerebrospinal fluid (CSF) antibodies against antigens of Treponema pallidum were assessed by Western blotting in patients with clinical signs of parenchymal or meningovascular neurosyphilis. All nine patients showed local production of treponeme-spe...
Gespeichert in:
| Veröffentlicht in: | Journal of neurology 1993-09, Vol.240 (8), p.471-474 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 474 |
|---|---|
| container_issue | 8 |
| container_start_page | 471 |
| container_title | Journal of neurology |
| container_volume | 240 |
| creator | BOLLENSEN, E ALBRECHT, S BEUCHE, W MÄDER, M PRANGE, H. W |
| description | The reactivity and specificity of locally produced cerebrospinal fluid (CSF) antibodies against antigens of Treponema pallidum were assessed by Western blotting in patients with clinical signs of parenchymal or meningovascular neurosyphilis. All nine patients showed local production of treponeme-specific antibodies in the central nervous system (CNS). In most of the patients serum and CSF antibodies were bound to the same antigens: the common treponemal 48/45 kDa protein and the putative specific T. pallidum protein in the range of 12-14 kDa. In some patients the intensity of staining obtained by CSF antibodies was higher than that derived from serum, indicating locally produced antibodies. In contrast to other more acute inflammatory CNS diseases, no expanded or different antigen binding of the CSF antibodies compared with serum antibodies was found in neurosyphilic patients. The results presented are discussed with regard to the role of the blood-brain barrier in antibody concentrations of CSF and serum. |
| doi_str_mv | 10.1007/BF00874115 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_76145904</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76145904</sourcerecordid><originalsourceid>FETCH-LOGICAL-p235t-2d212e750ab844c9c04f8bfa2ce988fbe07191cdc5f9e597c025dccb5aae0d2f3</originalsourceid><addsrcrecordid>eNo9kEFLwzAYhoMoc04v3oUcxFs1SZO1PepwKgwEneeSJl-2SJrWJlX6761aPH2H53lf-F6Ezim5poRkN3drQvKMUyoO0JzylCWUi-IQzUnKSSJSwY_RSQjvZNRGMEOznC1TIdgchReQKtpPGwfcGOwaJZ0bcNs1uleg8ep1jaWPtmq0hYCtx62MFnwM-MvGPfbQd00Y2r11NmC5k9aH-JvYgQ8_ldsO2sZDLcekc1b39Sk6MtIFOJvuAr2t77erx2Tz_PC0ut0kLUtFTJhmlEEmiKxyzlWhCDd5ZSRTUOS5qYBktKBKK2EKEEWmCBNaqUpICUQzky7Q1V_v-M1HDyGWtQ0KnJMemj6U2fJnJsJH8WIS-6oGXbadrWU3lNNKI7-cuAzjPqaTXtnwr6X5UhQFSb8BJzF4LQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76145904</pqid></control><display><type>article</type><title>Reactivity of locally produced CSF antibodies in patients with neurosyphilis against antigens of Treponema pallidum</title><source>MEDLINE</source><source>Springer Online Journals</source><creator>BOLLENSEN, E ; ALBRECHT, S ; BEUCHE, W ; MÄDER, M ; PRANGE, H. W</creator><creatorcontrib>BOLLENSEN, E ; ALBRECHT, S ; BEUCHE, W ; MÄDER, M ; PRANGE, H. W</creatorcontrib><description>The reactivity and specificity of locally produced cerebrospinal fluid (CSF) antibodies against antigens of Treponema pallidum were assessed by Western blotting in patients with clinical signs of parenchymal or meningovascular neurosyphilis. All nine patients showed local production of treponeme-specific antibodies in the central nervous system (CNS). In most of the patients serum and CSF antibodies were bound to the same antigens: the common treponemal 48/45 kDa protein and the putative specific T. pallidum protein in the range of 12-14 kDa. In some patients the intensity of staining obtained by CSF antibodies was higher than that derived from serum, indicating locally produced antibodies. In contrast to other more acute inflammatory CNS diseases, no expanded or different antigen binding of the CSF antibodies compared with serum antibodies was found in neurosyphilic patients. The results presented are discussed with regard to the role of the blood-brain barrier in antibody concentrations of CSF and serum.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/BF00874115</identifier><identifier>PMID: 8263552</identifier><identifier>CODEN: JNRYA9</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Aged ; Antibody Formation ; Antigens, Bacterial - immunology ; Bacterial diseases ; Biological and medical sciences ; Blotting, Western ; Cross Reactions ; Female ; Human bacterial diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Neurosyphilis - cerebrospinal fluid ; Neurosyphilis - immunology ; Treponema pallidum - immunology</subject><ispartof>Journal of neurology, 1993-09, Vol.240 (8), p.471-474</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3865990$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8263552$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BOLLENSEN, E</creatorcontrib><creatorcontrib>ALBRECHT, S</creatorcontrib><creatorcontrib>BEUCHE, W</creatorcontrib><creatorcontrib>MÄDER, M</creatorcontrib><creatorcontrib>PRANGE, H. W</creatorcontrib><title>Reactivity of locally produced CSF antibodies in patients with neurosyphilis against antigens of Treponema pallidum</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><description>The reactivity and specificity of locally produced cerebrospinal fluid (CSF) antibodies against antigens of Treponema pallidum were assessed by Western blotting in patients with clinical signs of parenchymal or meningovascular neurosyphilis. All nine patients showed local production of treponeme-specific antibodies in the central nervous system (CNS). In most of the patients serum and CSF antibodies were bound to the same antigens: the common treponemal 48/45 kDa protein and the putative specific T. pallidum protein in the range of 12-14 kDa. In some patients the intensity of staining obtained by CSF antibodies was higher than that derived from serum, indicating locally produced antibodies. In contrast to other more acute inflammatory CNS diseases, no expanded or different antigen binding of the CSF antibodies compared with serum antibodies was found in neurosyphilic patients. The results presented are discussed with regard to the role of the blood-brain barrier in antibody concentrations of CSF and serum.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibody Formation</subject><subject>Antigens, Bacterial - immunology</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>Cross Reactions</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Neurosyphilis - cerebrospinal fluid</subject><subject>Neurosyphilis - immunology</subject><subject>Treponema pallidum - immunology</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEFLwzAYhoMoc04v3oUcxFs1SZO1PepwKgwEneeSJl-2SJrWJlX6761aPH2H53lf-F6Ezim5poRkN3drQvKMUyoO0JzylCWUi-IQzUnKSSJSwY_RSQjvZNRGMEOznC1TIdgchReQKtpPGwfcGOwaJZ0bcNs1uleg8ep1jaWPtmq0hYCtx62MFnwM-MvGPfbQd00Y2r11NmC5k9aH-JvYgQ8_ldsO2sZDLcekc1b39Sk6MtIFOJvuAr2t77erx2Tz_PC0ut0kLUtFTJhmlEEmiKxyzlWhCDd5ZSRTUOS5qYBktKBKK2EKEEWmCBNaqUpICUQzky7Q1V_v-M1HDyGWtQ0KnJMemj6U2fJnJsJH8WIS-6oGXbadrWU3lNNKI7-cuAzjPqaTXtnwr6X5UhQFSb8BJzF4LQ</recordid><startdate>19930901</startdate><enddate>19930901</enddate><creator>BOLLENSEN, E</creator><creator>ALBRECHT, S</creator><creator>BEUCHE, W</creator><creator>MÄDER, M</creator><creator>PRANGE, H. W</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19930901</creationdate><title>Reactivity of locally produced CSF antibodies in patients with neurosyphilis against antigens of Treponema pallidum</title><author>BOLLENSEN, E ; ALBRECHT, S ; BEUCHE, W ; MÄDER, M ; PRANGE, H. W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-2d212e750ab844c9c04f8bfa2ce988fbe07191cdc5f9e597c025dccb5aae0d2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibody Formation</topic><topic>Antigens, Bacterial - immunology</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Blotting, Western</topic><topic>Cross Reactions</topic><topic>Female</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Neurosyphilis - cerebrospinal fluid</topic><topic>Neurosyphilis - immunology</topic><topic>Treponema pallidum - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BOLLENSEN, E</creatorcontrib><creatorcontrib>ALBRECHT, S</creatorcontrib><creatorcontrib>BEUCHE, W</creatorcontrib><creatorcontrib>MÄDER, M</creatorcontrib><creatorcontrib>PRANGE, H. W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BOLLENSEN, E</au><au>ALBRECHT, S</au><au>BEUCHE, W</au><au>MÄDER, M</au><au>PRANGE, H. W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reactivity of locally produced CSF antibodies in patients with neurosyphilis against antigens of Treponema pallidum</atitle><jtitle>Journal of neurology</jtitle><addtitle>J Neurol</addtitle><date>1993-09-01</date><risdate>1993</risdate><volume>240</volume><issue>8</issue><spage>471</spage><epage>474</epage><pages>471-474</pages><issn>0340-5354</issn><eissn>1432-1459</eissn><coden>JNRYA9</coden><abstract>The reactivity and specificity of locally produced cerebrospinal fluid (CSF) antibodies against antigens of Treponema pallidum were assessed by Western blotting in patients with clinical signs of parenchymal or meningovascular neurosyphilis. All nine patients showed local production of treponeme-specific antibodies in the central nervous system (CNS). In most of the patients serum and CSF antibodies were bound to the same antigens: the common treponemal 48/45 kDa protein and the putative specific T. pallidum protein in the range of 12-14 kDa. In some patients the intensity of staining obtained by CSF antibodies was higher than that derived from serum, indicating locally produced antibodies. In contrast to other more acute inflammatory CNS diseases, no expanded or different antigen binding of the CSF antibodies compared with serum antibodies was found in neurosyphilic patients. The results presented are discussed with regard to the role of the blood-brain barrier in antibody concentrations of CSF and serum.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>8263552</pmid><doi>10.1007/BF00874115</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-5354 |
| ispartof | Journal of neurology, 1993-09, Vol.240 (8), p.471-474 |
| issn | 0340-5354 1432-1459 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76145904 |
| source | MEDLINE; Springer Online Journals |
| subjects | Adult Aged Antibody Formation Antigens, Bacterial - immunology Bacterial diseases Biological and medical sciences Blotting, Western Cross Reactions Female Human bacterial diseases Humans Infectious diseases Male Medical sciences Middle Aged Miscellaneous Neurosyphilis - cerebrospinal fluid Neurosyphilis - immunology Treponema pallidum - immunology |
| title | Reactivity of locally produced CSF antibodies in patients with neurosyphilis against antigens of Treponema pallidum |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T17%3A09%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Reactivity%20of%20locally%20produced%20CSF%20antibodies%20in%20patients%20with%20neurosyphilis%20against%20antigens%20of%20Treponema%20pallidum&rft.jtitle=Journal%20of%20neurology&rft.au=BOLLENSEN,%20E&rft.date=1993-09-01&rft.volume=240&rft.issue=8&rft.spage=471&rft.epage=474&rft.pages=471-474&rft.issn=0340-5354&rft.eissn=1432-1459&rft.coden=JNRYA9&rft_id=info:doi/10.1007/BF00874115&rft_dat=%3Cproquest_pubme%3E76145904%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76145904&rft_id=info:pmid/8263552&rfr_iscdi=true |