Chorionic villus sampling for first-trimester Prenatal diagnosis: Northwestern University Program
We present our initial experience in developing a chorionic villus sampling program at Northwestern University. In phase 1, we performed chorionic villus sampling in 58 patients prior to elective first-trimester abortion, assessing the reliability and reproducibility of obtaining adequate villus sam...
Gespeichert in:
| Veröffentlicht in: | American journal of obstetrics and gynecology 1985-05, Vol.152 (2), p.204-213 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 213 |
|---|---|
| container_issue | 2 |
| container_start_page | 204 |
| container_title | American journal of obstetrics and gynecology |
| container_volume | 152 |
| creator | Elias, Sherman Simpson, Joe Leigh Martin, Alice O. Sabbagha, Rudy E. Gerbie, Albert B. Keith, Louis G. |
| description | We present our initial experience in developing a chorionic villus sampling program at Northwestern University. In phase 1, we performed chorionic villus sampling in 58 patients prior to elective first-trimester abortion, assessing the reliability and reproducibility of obtaining adequate villus samples and performing cytogenetic analysis by means of both the direct and culture methods. Specimens were categorized according to quality: class I, multiple identifiable villi (n = 20); class II, few villi or villi mixed with decidua (n = 15); class III, no villi (n = 23). There was a positive trend between operator experience, amount of villi obtained, and quality of cytogenetic preparations. In March, 1984, we received Institutional Review Board approval to perform chorionic villus sampling in continuing pregnancies (phase 2). Among the first 20 cases we found two abnormalities (47,XY, + 13; 45,X). The remaining 18 pregnancies were continuing. Recommendations are made for developing a chorionic villus sampling program. |
| doi_str_mv | 10.1016/S0002-9378(85)80023-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76145095</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002937885800235</els_id><sourcerecordid>76145095</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-aa0a6a79a064a0c32c78cfea38522b2427c6e8d32d3a5ca2b015d626adb7ffb53</originalsourceid><addsrcrecordid>eNqFkF1LwzAUhoMoc05_wqBXohfVNGnS1BuR4RcMFXTX4TRNt0ibzKSb7N_bbmO3Xh1e3vd8PQiNE3yT4ITffmKMSZzTTFwJdi06QWN2hIYJzrOYCy6O0fAQOUVnIXz3kuRkgAZU5JilbIhgsnDeOGtUtDZ1vQpRgGZZGzuPKuejyvjQxq03jQ6t9tGH1xZaqKPSwNy6YMJd9OZ8u_jd-jaaWbPWPph202Xd3ENzjk4qqIO-2NcRmj09fk1e4un78-vkYRqrlPA2BsDAIcsB8xSwokRlQlUaqGCEFCQlmeJalJSUFJgCUuCElZxwKIusqgpGR-hyN3fp3c-qO0c2Jihd12C1WwWZ8SRlOO-DbBdU3oXgdSWX3X_gNzLBskcrt2hlz00KJrdoZd833i9YFY0uD117lp1_v_N19-XaaC-DMtoqXRqvVStLZ_7Z8AerH4tT</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76145095</pqid></control><display><type>article</type><title>Chorionic villus sampling for first-trimester Prenatal diagnosis: Northwestern University Program</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Elias, Sherman ; Simpson, Joe Leigh ; Martin, Alice O. ; Sabbagha, Rudy E. ; Gerbie, Albert B. ; Keith, Louis G.</creator><creatorcontrib>Elias, Sherman ; Simpson, Joe Leigh ; Martin, Alice O. ; Sabbagha, Rudy E. ; Gerbie, Albert B. ; Keith, Louis G.</creatorcontrib><description>We present our initial experience in developing a chorionic villus sampling program at Northwestern University. In phase 1, we performed chorionic villus sampling in 58 patients prior to elective first-trimester abortion, assessing the reliability and reproducibility of obtaining adequate villus samples and performing cytogenetic analysis by means of both the direct and culture methods. Specimens were categorized according to quality: class I, multiple identifiable villi (n = 20); class II, few villi or villi mixed with decidua (n = 15); class III, no villi (n = 23). There was a positive trend between operator experience, amount of villi obtained, and quality of cytogenetic preparations. In March, 1984, we received Institutional Review Board approval to perform chorionic villus sampling in continuing pregnancies (phase 2). Among the first 20 cases we found two abnormalities (47,XY, + 13; 45,X). The remaining 18 pregnancies were continuing. Recommendations are made for developing a chorionic villus sampling program.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/S0002-9378(85)80023-5</identifier><identifier>PMID: 3890545</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Catheterization - methods ; Cells, Cultured ; Chorionic Villi - cytology ; Chorionic villus sampling ; Chromosome Aberrations - diagnosis ; Chromosome Banding ; Chromosome Disorders ; Female ; Genetic Testing - methods ; genetics ; Humans ; Pregnancy ; Pregnancy Trimester, First ; prenatal diagnosis ; Prenatal Diagnosis - methods ; Risk ; Ultrasonography - methods</subject><ispartof>American journal of obstetrics and gynecology, 1985-05, Vol.152 (2), p.204-213</ispartof><rights>1985 Mosby</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-aa0a6a79a064a0c32c78cfea38522b2427c6e8d32d3a5ca2b015d626adb7ffb53</citedby><cites>FETCH-LOGICAL-c426t-aa0a6a79a064a0c32c78cfea38522b2427c6e8d32d3a5ca2b015d626adb7ffb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0002-9378(85)80023-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3890545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elias, Sherman</creatorcontrib><creatorcontrib>Simpson, Joe Leigh</creatorcontrib><creatorcontrib>Martin, Alice O.</creatorcontrib><creatorcontrib>Sabbagha, Rudy E.</creatorcontrib><creatorcontrib>Gerbie, Albert B.</creatorcontrib><creatorcontrib>Keith, Louis G.</creatorcontrib><title>Chorionic villus sampling for first-trimester Prenatal diagnosis: Northwestern University Program</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>We present our initial experience in developing a chorionic villus sampling program at Northwestern University. In phase 1, we performed chorionic villus sampling in 58 patients prior to elective first-trimester abortion, assessing the reliability and reproducibility of obtaining adequate villus samples and performing cytogenetic analysis by means of both the direct and culture methods. Specimens were categorized according to quality: class I, multiple identifiable villi (n = 20); class II, few villi or villi mixed with decidua (n = 15); class III, no villi (n = 23). There was a positive trend between operator experience, amount of villi obtained, and quality of cytogenetic preparations. In March, 1984, we received Institutional Review Board approval to perform chorionic villus sampling in continuing pregnancies (phase 2). Among the first 20 cases we found two abnormalities (47,XY, + 13; 45,X). The remaining 18 pregnancies were continuing. Recommendations are made for developing a chorionic villus sampling program.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Catheterization - methods</subject><subject>Cells, Cultured</subject><subject>Chorionic Villi - cytology</subject><subject>Chorionic villus sampling</subject><subject>Chromosome Aberrations - diagnosis</subject><subject>Chromosome Banding</subject><subject>Chromosome Disorders</subject><subject>Female</subject><subject>Genetic Testing - methods</subject><subject>genetics</subject><subject>Humans</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>prenatal diagnosis</subject><subject>Prenatal Diagnosis - methods</subject><subject>Risk</subject><subject>Ultrasonography - methods</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LwzAUhoMoc05_wqBXohfVNGnS1BuR4RcMFXTX4TRNt0ibzKSb7N_bbmO3Xh1e3vd8PQiNE3yT4ITffmKMSZzTTFwJdi06QWN2hIYJzrOYCy6O0fAQOUVnIXz3kuRkgAZU5JilbIhgsnDeOGtUtDZ1vQpRgGZZGzuPKuejyvjQxq03jQ6t9tGH1xZaqKPSwNy6YMJd9OZ8u_jd-jaaWbPWPph202Xd3ENzjk4qqIO-2NcRmj09fk1e4un78-vkYRqrlPA2BsDAIcsB8xSwokRlQlUaqGCEFCQlmeJalJSUFJgCUuCElZxwKIusqgpGR-hyN3fp3c-qO0c2Jihd12C1WwWZ8SRlOO-DbBdU3oXgdSWX3X_gNzLBskcrt2hlz00KJrdoZd833i9YFY0uD117lp1_v_N19-XaaC-DMtoqXRqvVStLZ_7Z8AerH4tT</recordid><startdate>19850515</startdate><enddate>19850515</enddate><creator>Elias, Sherman</creator><creator>Simpson, Joe Leigh</creator><creator>Martin, Alice O.</creator><creator>Sabbagha, Rudy E.</creator><creator>Gerbie, Albert B.</creator><creator>Keith, Louis G.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19850515</creationdate><title>Chorionic villus sampling for first-trimester Prenatal diagnosis: Northwestern University Program</title><author>Elias, Sherman ; Simpson, Joe Leigh ; Martin, Alice O. ; Sabbagha, Rudy E. ; Gerbie, Albert B. ; Keith, Louis G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-aa0a6a79a064a0c32c78cfea38522b2427c6e8d32d3a5ca2b015d626adb7ffb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Catheterization - methods</topic><topic>Cells, Cultured</topic><topic>Chorionic Villi - cytology</topic><topic>Chorionic villus sampling</topic><topic>Chromosome Aberrations - diagnosis</topic><topic>Chromosome Banding</topic><topic>Chromosome Disorders</topic><topic>Female</topic><topic>Genetic Testing - methods</topic><topic>genetics</topic><topic>Humans</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>prenatal diagnosis</topic><topic>Prenatal Diagnosis - methods</topic><topic>Risk</topic><topic>Ultrasonography - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elias, Sherman</creatorcontrib><creatorcontrib>Simpson, Joe Leigh</creatorcontrib><creatorcontrib>Martin, Alice O.</creatorcontrib><creatorcontrib>Sabbagha, Rudy E.</creatorcontrib><creatorcontrib>Gerbie, Albert B.</creatorcontrib><creatorcontrib>Keith, Louis G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elias, Sherman</au><au>Simpson, Joe Leigh</au><au>Martin, Alice O.</au><au>Sabbagha, Rudy E.</au><au>Gerbie, Albert B.</au><au>Keith, Louis G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chorionic villus sampling for first-trimester Prenatal diagnosis: Northwestern University Program</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1985-05-15</date><risdate>1985</risdate><volume>152</volume><issue>2</issue><spage>204</spage><epage>213</epage><pages>204-213</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><abstract>We present our initial experience in developing a chorionic villus sampling program at Northwestern University. In phase 1, we performed chorionic villus sampling in 58 patients prior to elective first-trimester abortion, assessing the reliability and reproducibility of obtaining adequate villus samples and performing cytogenetic analysis by means of both the direct and culture methods. Specimens were categorized according to quality: class I, multiple identifiable villi (n = 20); class II, few villi or villi mixed with decidua (n = 15); class III, no villi (n = 23). There was a positive trend between operator experience, amount of villi obtained, and quality of cytogenetic preparations. In March, 1984, we received Institutional Review Board approval to perform chorionic villus sampling in continuing pregnancies (phase 2). Among the first 20 cases we found two abnormalities (47,XY, + 13; 45,X). The remaining 18 pregnancies were continuing. Recommendations are made for developing a chorionic villus sampling program.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>3890545</pmid><doi>10.1016/S0002-9378(85)80023-5</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9378 |
| ispartof | American journal of obstetrics and gynecology, 1985-05, Vol.152 (2), p.204-213 |
| issn | 0002-9378 1097-6868 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76145095 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Adult Catheterization - methods Cells, Cultured Chorionic Villi - cytology Chorionic villus sampling Chromosome Aberrations - diagnosis Chromosome Banding Chromosome Disorders Female Genetic Testing - methods genetics Humans Pregnancy Pregnancy Trimester, First prenatal diagnosis Prenatal Diagnosis - methods Risk Ultrasonography - methods |
| title | Chorionic villus sampling for first-trimester Prenatal diagnosis: Northwestern University Program |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T13%3A22%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chorionic%20villus%20sampling%20for%20first-trimester%20Prenatal%20diagnosis:%20Northwestern%20University%20Program&rft.jtitle=American%20journal%20of%20obstetrics%20and%20gynecology&rft.au=Elias,%20Sherman&rft.date=1985-05-15&rft.volume=152&rft.issue=2&rft.spage=204&rft.epage=213&rft.pages=204-213&rft.issn=0002-9378&rft.eissn=1097-6868&rft_id=info:doi/10.1016/S0002-9378(85)80023-5&rft_dat=%3Cproquest_cross%3E76145095%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76145095&rft_id=info:pmid/3890545&rft_els_id=S0002937885800235&rfr_iscdi=true |